Date: 01-08-2018
0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours

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Max Marks: 50
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1.Write short notes on the

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following
a) Metabolic acidosis (A. 402)
(10)
(C.481)
b) Lactose intolerance

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c) Fatty liver and lipotropic factors (A.

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204) (C.322)
2.Write Short notes of (any three)
a) Biomedical importance of any two (9)
mucopolysaccharides

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b) Competitive inhibition of enzymes.
(A. 63) (C. 92)
c) Nutritional classification of fatty acids
and their importance(C.509)
d) Clinical manifestations of any two

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porphyrias (A. 328) (C. 212)
e) Therapeutic uses of enzymes(A. 84)
(C. 105)
3.Discuss Any TWO
a) Appications of Radioimmunoassa (

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y 6)
(A. 436) (C.729)
b) Role of any two blood buffers(A.
398) (C. 475)
c) Role of clearance tests in kidney

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function(A. 370) (C.460)
Section 2

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4.Write Short notes on (any two)
a) Biochemical changes in
(10)

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atherosclerosis
b) glycolysis-aerobic and
anaerobic(A.128) (C. 245)
c) B-oxidation of palmitic acid(A. 191)
(C.287)

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5.Write Short notes on (any two)
a) Air pollutants(A. 534) (C. 663)
(9)
b) Chemical carcinogens (A. 662)
(C.667)

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c) Inhibitors of Electron transport chain
9ETC) (A. 320) (C.232)
d) Immunoglobulin G (Ig G)(A. 649) (C.
187)
e) Therapeutic application of

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radiosotopes
6.Case report:
(6)
A 34 years male with high grade
fever and shivering was admitted to the

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hospital on treatment with antimalarial
drugs fever subsided but he developed
acute haemolytic crisis, signs of
anemia, pallor of the skin and the
mucus membrane. Oedema feet

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jaundice. The patient noticed dark
coloured urine. Laboratory
investigations revealed reduced
haemoglobin levels. Reticulocyte count
6.5% (N=upto 2%), Serum total bilirubin

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9.6 mgs/dl (N=.2- 1.0 mgs/dl). Activity
of glucose 6 phosphate dehydrogrnase
(G6PD) was found deficient. Answer
the following questions (any six).
1) State the biochemical basis of

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development of haemolytic disease in
this patient.
2) What is glutathione and what is its
role in the body?
3) How does glutathione fail to perform

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its function following administration of
antimalarial drugs?
4) Comment on why the dark coloured
urine is observed.
5) Does the disorder affect the other

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tissues of the body? Explain
6) Does G6 PD deficiency in this patient
offer any advantage? If yes Explain
7) Name any antimalarial drug
responsible for this condition

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8) Name any abnormal test result in this
case suggesting hemolysis

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Document Outline

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