Date: 01-08-2019
0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Write short notes on the following
a) Tumors markers
b) Type I Fatty Liver
c) Metabolic derangements in Diabetes
Mellitus
a) Functions of Prostaglandins
b) Homopolysaccharides
c) Acute Intermittent Porphyria
d) Diagnostic Applications of Enzymes
pH on enzyme action
3. Discuss Any TWO
(6)
a) Application of ELISA
b) Tests to detect on Glomerular Function
c) Role of Hemoglobin as a buffer
Section 2
4. Write Short notes on (any two) (10)
a) Ketone body Metabolism
(TCA)cycle
c) Gluconeogenesis
5. Write Short notes on (any two)
(9)
b) Inhibitors of Electron Transport chain
and oxidative Phosphorylation
c) Oncogenes
d) Therapeutic Application of
e) Carcinogens
6. Case report: 10 year old boy
residing in a slum was brought to the
pediatric OPD with compliants of
headache, weakness and myalgia
(6)
for 2 weeks.The boy had development
jaundice since 1 day and also passed dark
patients with similar complaints in the
neighborhood. Physical examination.Patiant
showed signs icterus and tenderness in the
right hypochondriac
region.Laboratory/Investigations:Serum
Bilirubin:Total-3 mg/dl, indirect-1.2 mg/dl,
Direct-1.8 mg/dl, Serum Total protein-7.5
g/dl.Serum albumin-4.9 g/dl,SGOT-500
IU/L, SGPT-675IU/L,Serum Alkaline
routine:Fouchet test & Hays sulfur test:+Ve
Answer the following questions (any six)
1) What is your probable diagnosis?
2) The boy is suffering from which type of
3) Comment on the levels of liver
enzymes.
4) Why both direct and indirect bilirubin
have raised?
albumin levels.
6) How will you differentiate between
three types of jaundice based on enzyme
assays
urine?
8) How will you confirm the same?
0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
--- Content provided by FirstRanker.com ---
Max Marks: 50Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
--- Content provided by FirstRanker.com ---
section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Write short notes on the following
--- Content provided by FirstRanker.com ---
(10)a) Tumors markers
b) Type I Fatty Liver
c) Metabolic derangements in Diabetes
Mellitus
--- Content provided by FirstRanker.com ---
2. Write Short notes of (any three) (9)a) Functions of Prostaglandins
b) Homopolysaccharides
c) Acute Intermittent Porphyria
d) Diagnostic Applications of Enzymes
--- Content provided by FirstRanker.com ---
e) Effect of Substrate Concentration andpH on enzyme action
3. Discuss Any TWO
(6)
a) Application of ELISA
--- Content provided by FirstRanker.com ---
b) Tests to detect on Glomerular Function
c) Role of Hemoglobin as a buffer
Section 2
4. Write Short notes on (any two) (10)
a) Ketone body Metabolism
--- Content provided by FirstRanker.com ---
b) Amphibolic Role of Tricarboxylic acid(TCA)cycle
c) Gluconeogenesis
5. Write Short notes on (any two)
(9)
--- Content provided by FirstRanker.com ---
a) Immunoglobulin structureb) Inhibitors of Electron Transport chain
and oxidative Phosphorylation
c) Oncogenes
d) Therapeutic Application of
--- Content provided by FirstRanker.com ---
Radioisotopese) Carcinogens
6. Case report: 10 year old boy
residing in a slum was brought to the
pediatric OPD with compliants of
--- Content provided by FirstRanker.com ---
fever, anorexia, nausea vomitingheadache, weakness and myalgia
(6)
for 2 weeks.The boy had development
jaundice since 1 day and also passed dark
--- Content provided by FirstRanker.com ---
yellow coloured urine. There were otherpatients with similar complaints in the
neighborhood. Physical examination.Patiant
showed signs icterus and tenderness in the
right hypochondriac
--- Content provided by FirstRanker.com ---
region.Laboratory/Investigations:Serum
Bilirubin:Total-3 mg/dl, indirect-1.2 mg/dl,
Direct-1.8 mg/dl, Serum Total protein-7.5
g/dl.Serum albumin-4.9 g/dl,SGOT-500
IU/L, SGPT-675IU/L,Serum Alkaline
--- Content provided by FirstRanker.com ---
phosphate-17KAU/100 ml, Urineroutine:Fouchet test & Hays sulfur test:+Ve
Answer the following questions (any six)
1) What is your probable diagnosis?
2) The boy is suffering from which type of
--- Content provided by FirstRanker.com ---
jaundice?3) Comment on the levels of liver
enzymes.
4) Why both direct and indirect bilirubin
have raised?
--- Content provided by FirstRanker.com ---
5) Comment on serum total proteins andalbumin levels.
6) How will you differentiate between
three types of jaundice based on enzyme
assays
--- Content provided by FirstRanker.com ---
7) What is the causes of dark yellow colorurine?
8) How will you confirm the same?