0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
Max Marks: 50

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Date: 10-01-2013
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Give an account of any TWO of the

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following
(10)
a) Explain in brief competitive
inhibition and its application in drug
therapy (A. 63) (C.92)

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b) Describe the chromatography
technique and its application in
biochemical analysis. (A.434)(C.719)
c) Give an account of hemoglobin with
altered primary structure. (A.339)

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(C.203)
2. Write Short notes of (any three) (9)
a) Mucopolysaccharides and their
functions (A. 98) (C.22)
b) What are isoenzymes and give 2

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examples of isoenzyme forms of
clinical importance (A.69, 79) (C.112)
c) What is Vanden Bergh test its
application in differential diagnosis of
jaundice (A. 359)

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d) Phospholipids and their biological
function (A. 108) (C.34)
e) Lactic acidosis (A. 171) (C.248)
3. Discuss Any TWO
(6)

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a) Liver function tests based on its
synthetic functions (A. 361) (C.453)
b) Anion gap and its clinical application
in diagnosis of acid-base imbalance

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(A. 403) (C.480)

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c) Western blot technique and its
applications (A. 609) (C.589)
Section 2
4. Write Short notes on (any two) (10)
a) Explain various steps in

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gluconeogenesis and its physiological
significance (A. 135) (C.258)
b) How palmitic acid (C16) is oxidized
completely to acetyl Co-enzymeA
through beta oxidation with energetic.

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(A. 194) (C.287)
c) How 2,3bisphosphoglycerate is
produced and what is its significance
(A. 134) (C.251)
5. Write Short notes on (any two) (9)

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a) Uncouplers of Oxidative
phosphorylation. (A. 320)(C.233)
b) Tumor markers and their application
in diagnosis of different cancers (A.
666)(C.691)

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c) What are immunoglobulins? Give

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an account on structure and function
of different types of immunoglobulins.
(A. 649) (C.186)
d) Heavy metal poisoning (A. 532)

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(C.666)
e) Active transport system (A. 15)
(C.651)
6. Give your comments with
justification of Any SIX:

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(6)
a) Carbon monoxide inhibits cellular
respiration.
b) Ethyl alcohol as antidote for
methanol poisoning.

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c) ATP inhibits glycolysis
d) Urine titrable acidity in metabolic
acidosis.
e) Thiamine deficiency leads to
impaired carbohydrate metabolism.

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f) Increase in serum LDL a risk factor
for atherosclerosis.
g) Uncontrolled diabetes leads to
metabolic acidosis
h) Vitamin B12 deficiency leads to

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methyl malonicaciduria.

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