0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
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Max Marks: 1001. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Write the following structured long
question:( (Any 1 out of 2)
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(10)a) What are the indications of glucose
tolerance test? What precautions need to
be taken before doing a GTT? What are
the abnormal curves obtained? What is
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impaired glucose tolerance (IGT).
(2+2+3+3=10)
b) What are different
transport mechanisms of human cells
draw labeled diagram of cell & sub
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cellular organelles. Enumerate themetabolic pathways taking place in cell
& mitochondria.
(1+1+2+6=10)
2. Write the following case based
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scenario/Applied short notes: (Any 2 out of3)
(12)
a) A 35 year old poor farmer on
irregular diet admitted in Govt. hospital
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with history of frequent diarrheadermatitis around neck & other body
parts with intermittent loss of memory
since 2 month, on examination some
lesion around neck & dorsum of hand
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seen. He is Cultivating maize crops &using it in excess as a staple diet since
10 years.i) What is the diagnosis in
above case.ii) Which vitamin deficiency
cause above disorder.iii) Name of lesion
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around the neck.iv) Doesantituberculous drug isoniazid affect
synthesis.v) Which important amino
acid is deficient in maize? Does it have a
role as precursor to synthesise the
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deficient vitamin.b) Write short note on uncouplers of
oxidative phosphorylation & inhibitors
& ETC its types.
c) Write short note on Jaundice & what
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are different types of jaundice withlaboratory investigations.
3. Write short notes: (Any 3 out of 4)
(18)
a) Define Amphibolic pathways & write
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down biomedial importance ofAmphibolic pathways.
b) What is Substrate level
Phosphorylation. Describe Substrate
level phosphorylation with Biomedical
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importance.
c) What are 5 levels of communications
with patients and enumerate the seven
facilitatory elements that facilitate the
doctor patient communication.
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d) What are glycosaminoglycans?Describe distributions and functions of
various types of glycosaminoglycans.
4. Answer in 2-3 sentences only:(give
biochemical justification) (Any 5 out of 6)
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(10)a) Anaplerotic reactions of TCA
and its Biochemical Significance.
b) Difference between serum
cholinesterase and pseudo
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cholinesterase. Why this test isimportant before giving GA to patients.
c) Intravenous methylene blue is used in
treatment of methemoglobinemia.
d) Potassium given along with fluid
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d) Potassium given along with fluid
replacement is useful in treatment of
diabetic ketoacidosis induced Cerebral
edema.
e) Trop-l and CK-MB is specific for MI
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diagnosis.f) Potassium Cyanide (KCN) hamper the
production of ATP.
Section 2
5. Write the following structured long
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question: (Any 1 out of 2)(10)
a) Write down classification of enzymes
with examples. Define Isoenzymes with
examples and describe diagnosis
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importance of Isoenzymes withexamples.
(5+5=10)
b) What are fatty acids? Describe B-
oxidations of fatty acids and write down
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metabolic fate of Acetyl CoA. (2+8=10)6. Write short notes: (Any 2 out of 3)
(12)
a) Role of lung in maintaining acid base
balance.
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b) Discuss important biochemicalfunctions of K+ sodium and calcium.
c) Define Oncogenes. Types and
classifications of Oncogenes.
7. Write short notes: (Any 3 out of 4)
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(18)a) Metabolic acidosis.
b) RFLP
c) Prostacyclins
d) Enzymes as tumour markers.
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8. Answer in 2-3 sentences only: (Any 5 outof 6)
(10)
a) Biotransformation of Xenobiotics.
b) Difference between LCAT and
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ACAT.c) Various Mechanism of H+ secretions.
d) Henderson Hasselbalch equations.
e) Lipotropic Factors and Biochemical
functions.
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f) Methemoglobinemia.