0819E379
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 50Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Write short notes on the following:
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a) Primary Gout(A. 548) (C. 394) (10)b) Phenylketeauria
c) Vitamin B12 and Folate Trap (A.
478) (C. 156)
2. Write Short notes of (any three):
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a) Post Translational(9)
Modifications(A. 584) (C.561)
b) Properties of Genetic Code (A.
580) (C.551)
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c) tRNAd) Biologically important free
nucleotides
e) Lac Operon model(A. 596) (C.567)
3. Discuss Any TWO:
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a) Metabolic Changes during(6)
prolonged starvation(A. 122) (C. 383)
b) Balanced Diet(B. 761) (C.514)
c) Interlinking of metabolism at tissue
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levelSection 2
4. Write Short notes on (any two):
a) Functions of plasma
(10)
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Proteins(A. 385) (C.183)b) Maintenance of Serum Calcium
and Phosphorus balance
c) Trace elements(A. 491) (C.405)
5. Write Short notes on (any three):
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a) Functions of Vitamin C(A. 481) (9)(C.132)
b) Pellagra (A. 470) (C.141)
c) Vitamin A deficiency
d) Purine Salvage pathway (A. 546)
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(C. 391)e) Vitamin E Sources and
Biochemical Functions
6. Case report:
A 25 year old woman was admitted in
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hospital with complaints ofbreathlessness, palpitations with
generalizations edema. She also
complained of weakness of muscles,
difficulty in walking. She gave history of
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having consumed ultra-refined polishedrice for past two years. She also
avoided pulses, nuts and oil seeds in
her daily intake in an attempt to lose
weight.Erythrocyte transketolase
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activity was measured to be low.Answer the following questions (any
six):
(6)
1) What is your probable diagnosis?
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2) Which micronutrients is deficientin diet?
3) Mention its active forms
4) Why this women suffered from
deficiency of this micronutrient?
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5) Erythrocyte Transketolase isassociated with which pathway?
6) Give biochemical basis above of
signs and symptoms
7) What is Wernicke's korsakoff
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encephalopathy associated withdeficiency of this micronutrient?
8) Mention any one biochemical
reaction where this micronutrient is
acting as coenzymes.
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