0824E 209
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 1001. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Structured Long Question (Any 1
out of 2)
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(10)a) Write about Prokaryotic
transcription. Add a note on inhibitors
of transcription.
b) Write about the steps and
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applications of Recombinant DNAtechnology.
2. Case based/Applied short notes
(Any 2 out of 3)
(6)
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a) A 12 year old male child presentedwith complaints of back pain and knee
pain. Urine turns black after few hours
of exposure to atmospheric oxygen,
his ear pinna showed black
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pigmentation. What is the diagnosis?Explain the cause of symptoms and
sign. Name the pathway involved
Enumerate the other metabolic errors
in this pathway along with the
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respective enzyme deficient.(1+1+2+2=6)
b) A 46 years old man, a chronic
alcoholic and smoker, came to
hospital with a complaint of severe
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pain in the great toe. On examinationhis first metatarsophalangeal joint was
inflamed. Laboratory investigation
shows an increased level of serum
Uric acid =10mg/dl.(1+3+2=6):What
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is the probable diagnosis? What is theunderlying biochemical mechanism?
Which drug and life style changes are
preferred for the treatment of disease?
c) A one year old boy brought to the
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paediatric OPD with complaints of
one episode of generalized fits 2 days
ago and developmental delay. On
examination he had faircomplexion
and corneal golden/Green ring
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Biochemical investigations were -serum Copper = 45 mg/dl (70-
155me/dl), serum ceruloplasmin - 37
mg/dl (185-300 mg/dl) (1+3+2=6) 1.
What is the possible diagnosis? 2.
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Whichenzymes are affected in thisdisorder?. Justify the sign and
symptoms. 3. Write absorption and
transport of the deficient molecule.
3. Write short notes (Any 3 out of 4)
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(3x6 marks = 18 marks)a) ACPCR
and its applications.
b) Protein energy malnutrition.
c) Antioxidants and their examples.
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d) Mechanism of starvation.4. Answer only In 2-3 sentences (Any
5 out of 6)
(10)
a) Lesch Nyhan syndrome.
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b) ABR and factors affecting BMR.c) Integration of metabolism.
d) Diagnostically important
nucleotides.
e) Enumerate type and functions of
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RNA.f) Genetic code.
Section 2
5. Structured long question (Any 1
out of 2)
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(5x2 marks = 10 marks) (10)a) Write RDA, Sources, biochemical
functions and deficiency
manifestations of Vitamin C.
(1+1+4=4=10)
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b) Describe the metabolism ofPhenylalanine and tyrosine. Add a
note on inborn errors related to them.
6. Write short notes (Any 2 out of 3)
(12)
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a) Functions and deficiencymanifestations of Vitamin- A.
b) Biochemistry of AIDS.
c) PP Plasma proteins and their
functions.
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7. Write short notes (Any 3 out of 4)(18)
a) Explain important
transamination reactions with
examples.
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b) Mechanism of hormone action.c) Deficiency manifestations of
Calcium.
d) Structure of protein.
8. Answer only in 2-3 sentences (Any
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5 out of 6)(10)
a) A Enlist two important functions of
sodium (Na'*)
b) Enumerate four Diagnostically
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important peptides.c) Enumerate four important products
formed by transmethylation reaction.
d) Important functions of Niacin.
e) Denaturation of proteins.
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f) Functions of Zinc.