Download Gujarat University MBBS 1st Year 1123E356 Biochemistry Paper I Nov 2023 Question Paper

Date: 28-11-2023
1123E356
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours

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Max Marks: 100
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.

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4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1.Answer any one (10)
a) Describe the reactions of hexose

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monophosphate pathway. Mention the
significance of this pathway. Add
anote on clinical implication of this
pathway.
b) Desribe the structure of

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hemoglobin. Explain the sigmoidal
oxygen dissociation curve of
hemoglobin. What are the various
factors that affect the oxygen binding
to hemoglobin

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2.Answer any two(case based
scenario/applied short notes) (12)
a) A new born baby was bought with
yellowish discoloration of skin and
conjunctiva 3 days after birth. Lab

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reports revealed serum total
birubin=18mg/dl, serum unconjugated
bilirubin-16mg/dl,. He was advised
phototherapy by the neonatologist (a)
What is your diagnosis?(b) What is

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normal serum total, unconjugated and
conjugated bilirubin level?(c) Why
phototherapy was advised to the
baby? (1+3+2=6)

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b) Why do serum cholesterol levels

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depend upon the LDL receptor
activity? Explain the role of cholesterol
in atherosclerosis. Describe the
mechanism of action of
hypocholesteromic drugs.

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c) A 67 years old male with the history
of diabetes mellitus since 10 years
was admitted with complaints of
disorientation and fruity sodour breath.
Blood glucose was 420mg/dl and

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Rothera's test was positive. ABG
analysis showed- pH:Result 7.1
(Reference range 7.35-7.45),
pCO2:Result 28mmHg (Reference
range 35-45mmHg), p02:Result

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95mmHg (Reference range 75-
100mmHg), pCO3: Result 9mmol/L
(Reference range 22-26mmol/L),
Anion gap : Result 33mmol/L

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(Reference range 10-14mmol/L )

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(1+2+1+2=6). a) What is the probable
diagnosis. b) Explain the biochemical
basis of this disorder c) What is anion
gap? Give causes of increased anion
gap. d) What is the compensatory

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mechanism for this diorder.
3.Write short notes (answer any
three) (18)
a) Mucopolysaccharides and their
biomedical importance

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b) Complexes and inhibitors of
electron transport chain.
c) Polyol pathway and its significance
in diabetes mellitus
d) What are the qualities of a good

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doctor

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4.Answer in 2-3 lines (give
biochemical justification) five out of
six (10)
a) What is substrate level of

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phosphorylation? Give examples
b) Define creatine clearence
c) Enumerate inhibitors of Na+K+
pump
d) Enumerate the glycogen storage

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disorders
e) What are Bense Jone's proteins?
f) Give the molecular abnormality in
sickle cell anemia
Section 2

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5.Answer any one (10)
a) Describe the various factors

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a) Describe the various factors
affecting enzyme activity. Compare
and contrast competitive and non

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competitive enzyme inhibition with
examples.
b) Descibe beta oxidation of one
molecule of palmitic acid. Mention the
bioenergetics of the pathway. Add

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anote on its regulation
6.Answer any two (case based
scenario/applied short notes) (12)
a) Define isoenzyme with examples.
Add anote on their clinical

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significance.
b) Distinguish between passive,
facilitated and active transport
systems.
c) Describe charecteristics, structural

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features and functions of different
imminoglobulins
7.Write short notes (answer any
three) (18)
a) Classify phospholipids. Mention

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their composition & biological
significance.
b) What are proto oncogens? Mention
various mechanisms by which they are
activated to oncogens

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c) Phase II reactions of detoxification
d) Explain the role of various
hormones in the water balance.
8.Answer in 2-3 lines (give
biochemical justification) five out of

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six (10)
a) Define coenzyme? Enumerate

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a) Define coenzyme? Enumerate
coenzymes of riboflavin
b) What are lipotropic factores? Give

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examples
c) Enumerate causes of respiratory
alkalosis
d) Define essential fatty acids. Give
examples.

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e) Define tumor markers. Give
examples.
f) Enumerate applications of
electrophoresis

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