1123E357
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 100Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Answer any one (10)
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a) Give a detailed account of prokaryotictranscriptionHow the newy formed RNA is
processed. Name the inhibitors of
transcription
b) Briefly outline the salvage pathway of
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purine synthesis and its importance.
Explain the manifestations and biochemical
basis of Lesch Nyhan syndrome
2. Answer any two (case based
scenario/applied short notes) 12 (0)
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a) A 28 year old female presented withhistory of fatigue, anorexia,
constipationpoor memory, irritability sleep
disturbances, bilateral, symmetrical lower
extremity psresthesia with burning pain and
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muscle cramps. On examination she hasdecreased vibratory position sense, absent
ankle & knee jerk and muscle atrophy. her
diet consist of polished rice without pulses,
oil seed etc. The level of enzyme
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transketolase in RBC were low(1+1+1+3=6). a) What is your diagnosis?
Deficiency of which nutrient causes this
disorder? b)Explain the role of patient diet
in this disorder c) Enumerate the coenzyme
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form of this nutrient d) What is thebiochemical basis of clinical features of this
patient.
b) A 45 year old male presented with
complaints of pain in back & knee. His ear
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pinnae and sclera showed blackpigmentationBlackish pigmentation was
alsp seen on tthe skin of both the
palmsUrine turn black after few hours of
exposure to atmospheric oxygen. X ray
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spine showed narrowing of intervertebraldisc and lumbar lordosis. (1+1+2+2=6). a)
What is your diagnosis b) Name the
enzyme deficiency c) Explain the
biochemical basis of clinical feature in this
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case. d)What are the specialized productsof tyrosine?
c) A 45 year old non vegeterian, chronic
alcoholic patient came to orthopedic OPD
with complaints of acute pain in great toe,
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On examination there were signs ofinflammation. Labolatory investigation
reported serum uric acid level of 11 mg/dl.
(1+2+1+2=6). a) What is probable
diagnosis b)Enumerate the primary and
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secondory causes of condition c) What isthe relationship between alcohol and
symptoms in this case? d)What are the
treatment modalities in this case?
3. Write short notes (answer any three)
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(18)a) Differentiate kwashiorkor and marasmus
b) Restriction fragment length
polymorphism
c) Antioxidant defense system
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d) Metabolic adaptions in the starvation4. Answer in 2-3 lines (give biochemical
justification) five out of six (10)
a) Mention the enzymes used in the
recombinant DNA technology
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b) Enumerate various free radicals.c) What is the mechanism of action of
Zidovudine
d) Enumerate the types and functions of
RNA.
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e) Give the biochemical defect in odoticaciduria
f) Define basa; metabo;oc rate.
Section 2
5. Answer any one (10)
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a) What is transamination anddeamination? How ammonia transported
and metabolized? Give details of the urea
cycle. (2+3+5=10)
b) What are the biological active forms of
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the folc acid? Hpw it is involved in the onecarbon metabolisom? Explain the actions &
clinical importance of the folate antagonists
6. Answer any two (case based
scenario/applied short notes) (12)
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a) Calcium homeostasisb) Types of mutations and their effects with
examples
c) Structure of collagen and their disorder
7. Write short notes (answer any three)
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(18)a) Intestinal absorption of iron and various
factors involved in its regulation
b) Cushing syndrome
c) cheperones and disorders associated with
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them.d) Structural organisation of the proteins
8. Answer in 2-3 lines (give biochemical
justification) five out of six (10)
a) Enumerate specialized products of
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glycine.b) Give examples of second messangers
c) Enumerate the features of pellagra
d) What is flurosis?
e) Define zwitter iron
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f) What are acute phase proteins?