First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
Max Marks: 100
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Instructions:1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Structured Long Question (any 1
out of 2)
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1X10 Marks=10 Marks (10)a) Describe the dynamics of blood
glucose homeostasis. What are the roles
of the hormones in blood glucose
homeostasis?
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b) Describe Heme synthesis and itsregulation. Add a note on various
Porphyria.
2. Case Based Scenario / Applied
Short Notes (any 2 out of 3)
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a) A2X6 Marks=12 Marks (12)
newborn baby developed yellowish
discoloration on 3 day of life. He was
treated with phototherapy.
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i. What is the most probablediagnosis?
ii. Name the tests that will help with
the diagnosis.
iii. Explain the role of phototherapy in
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treatment.b) A young lady who had consumed a
large dose of aspirin in a suicide attempt
was admitted to the hospital. Her blood
gas analysis gave the following
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findings:-Parameter Obtained value; pHof the blood 7.5 pco, 16 mmHg: Anion
gap 26 mEq/L H
i. What is your probable diagnosis?
ii. What is the cause of the anion gap
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in the above case?iii. What are the body's defense
mechanisms to maintain pH?
c) A teenage boy came to the physician
with a complaint of frequent fatigue
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while playing. He also complained ofpainful muscle cramps on exertion.
Blood sample collected during exercise
revealed low glucose, lactate, and
pyruvate levels.
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i, What is the most probablediagnosis?
ii. Name the enzymes deficient in the
above case
iii) What is the cause of iow lactate
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and pyruvate in the above case?3. Write short notes (any 3 out of 4)
a) Inhibitors 3X6 Marks=18 Marks (18)
of Electron transport chain
b) Creatinine Clearance Test
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c) Tumor Markersd) Importance of effective
communication in the medical field
4. Auswer only in 2-3 Sentences (any
5 out of 6)
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5X2 Marks=10 Marks (10)a) Products of Tyrosine
b) domains of learning
c) Ketosis
d) Types of Immunoglobuli
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e) Tamm- Horsfall proteinf) Active transport snopes
Section 2
5. Structured Long Question (any 1
out of 2)
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1X10 Marks=10 Marks (10)a) Enumerate blood buffer systems.
Describe the role of buffers, kidneys,
and lungs in the maintenance of acid-
base balance.
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b) What are the different types ofenzyme inhibitors? Explain with
suitable examples,
6. Write Short Notes (any 2 out of 3)
a) Oxidation 2X6 Marks=12 Marks (12)
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of oddschain fatty acidsb) Hyperkalemia
c) Enzyme Linked Immunosorbent
Assay
7. Write Short Notes (any 3 out of 4)
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a)3X6 Marks=18 Marks (18)
Cytochrome P450
b) Refsum disease
c) Innate Immunity
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d) Oncogenes8. Answer only in 2-3 Sentences (any
5 out of 6)
5X2 Marks=10 Mark (10)
a) Essential and Semi-essential Amino
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Acidsb) Differentiate between Hexokinase
and Glucokinase
c) Explain the cause of congenital
cataracts in Galactosemia
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d) Why intake of alcohol leads tohypoglycemia
e) Lipotropic factors
f) Insulin-dependent tissues
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