1124E 364
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 100Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Structured Long Question (any 1
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out of 2)1X10 Marks=10 Marks
a) Describe the catabolism of purine
nucleotides and the disorders
associated with it.
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b) Describe eukaryotic translation andinhibitors of translation. Add a note on
post-translational modification.
2. Case Based Scenario / Applied
Short Notes (any 2 out of 3)
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a) A ninth-month- 2X6 Marks=12 Marksold infant is lethargic, irritable, vomit
frequently, and has convulsions. On
examination hepatomegaly was present
and blood ammonia levels and
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glutamine levels were elevated. Urineanalysis revealed a high amount of
uridine, uracil, and orotic acid. I. What
is the most probable diagnosis? II. Why
are uridine, uracil, and orotic acid
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elevated? III. What is the underlyingcause of this disorder?
b) A 6 years old fair, chubby boy was
bought to hospital with complaints of
delayed development milestones,
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mental retardation, seizures, andeczema. Blood phenylalanine levels
were more than 30 me/dL (normal 1-2
mg/dL). The urine was tested for ferric
chloride test which turns to be positive.
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I. What is the most probable diagnosis?II. Explain the cause of convulsions? III
Why affected children often have fairy
skin?
c) An adolescent girl presents with
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subluxation of lens and mentalretardation. On examination, she is tall
and thin with elongated limbs, mild
scoliosis was present with Pectus
excavatum and Genu valgum. One of
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her sisters had similar complaints. 1What is the most probable diagnosis?
2. What is the basis of the disease? 3.
Why is the risk of coronary artery
disease increased in such patients?
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3. Write Short Notes (any 3 out of 4)a) Beneficial
3X6 Marks=18 Marks
effects of Free Radicals
b) Glycemic Index
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c) Newborn Screeningd) Protein Energy Matnutrition
4. Answer only in 2-3 Sentences (any
5 out of 6)
5X2 Marks=10 Marks
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a) Severe Combined Immunodeficiencyb) Z-DNA
c) Alkaptonuria
d) Specific Dynamic Action
e) Wobble Hypothesis
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f) Beer-Lambert's LowSection 2
5. Structured Long Question (any 1
out of 2)
1X10 Marks=10 Marks
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a) Describe the metabolism ofTryptophan and diseases related to it,
What are the biologically important
substances produced by Tryptophan?
b) Describe the sources, biochemical
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function, RDA, and deficiencymanifestations of vitamin A.
6. Write Short Notes (any 2 out of 3)
a) Folate trap.
2X6 Marks=12 Marks
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b) Inhibitors of Replicationc) Vitamin C and its deficiency
manifestations.
7. Write Short Notes (any 3 out of 4)
a) Balanced Diet 3X6 Marks=18 Marks
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b) Protein targetingc) Selenium and its functions
d) Thyroid function test
8. Answer only in 2-3 Sentences (any
5 out of 6)
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5X2 Marks=10 Marksa) Diseases-treated by gene therapy
b) Zwitter lon
c) Limiting Amino Acids
d) Active form of vitamin B
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e) Ehlers-Danlos Syndromesf) Albinism