Date: 11-01-2019
0118E456
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours

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Max Marks: 50
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Write short notes on the following

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a) Alcohol and acute gouty arthritis (10)
b) Rickets and role of vitamin D(A.
459)(C.127,408)
c) Maple syrup urine disease(A. 282)
(C.365)

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2. Write Short notes of (any three) (9)

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a) Watson crick model of DNA
b) Salvage pathway of purine
synthesis(A. 546) (C.391)
c) Polymerase chain reaction(A. 612)

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(C.594)
d) Lac operon concept(A. 596) (C.567)
e) Post transitional modifications
3. Discuss Any TWO
(6)

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a) Basal metabolic rate (BMR)(A. 512)
(C.504)
b) Dietary fiber(A. 514)(C. 508)
c) Nitrogen balance
Section 2

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4. Write Short notes on (any two) (10)
a) Biochemical functions of selenium
(A. 504) (C.421)
b) Transamination(A. 256) (C. 332)
c) Secondary structure of proteins(A.

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38)(C. 56)
5. Write Short notes on (any two) (9)
a) Biochemical role of vitamin C
b) Regulation of purine synthesis

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c) Sources of carbon and nitrogen

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atoms in purine ring
d) Hem poetic vitamins
e) OroticAciduria(A. 551) (C.400)
6. Case report: One evening, a 40
year old male a businessman

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enjoyed a party in which he
sonsumed meat and alcohol. The
next morning he woke up with
excruciating
(6)

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pain in great toe. He was admitted in
the hospital, on examination, he had
fever his great toe was swollen, red
and too hot to touch and was tender
and stiff. Lymph nodes were normal

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not tender. The laboratory data
was:Blood glucose:130 mg/dl, Blood
urea:38mg/dl Serum Creatinine:1
mg/dl, Serum uric acid: 10 mg/dl,
Urine pH:6.2. Answer the following

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questions (any six).
1) What is the most probable
diagnosis?
2) Which part of the case history &
laboratory data helped you to reach

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the diagnosis?
3) What is the origin and fate of uric
acid?
4) What are the causes of primary and
secondary Hyperurecernia?

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5) What is the cause of gouty arthritis?
Explain the pathogenesis.
6) Which type of food will precipitate
an attack of gout?
7) What is the short term and long

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term treatment of gout?
8) What is the biochemical basis of
such treatment policy?

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Document Outline

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