0422E373
First Year MBBS Examination
I MBBS Physiology Paper 2
Time: 3 hours
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Instructions: 1. Answer to the points. 2. Useseparate answer books for each section. 3.
Draw diagrams wherever necessary.
Section 1
Max Marks: 100
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1. Write the following structured longquestion (any 1 out of 2) (10)
a. Discuss in detail the functions of cerebellum.
b. Explain the posterior column tracts in detail.
2. Write the following case - based scenario
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/ applied short notes (any 2 out of 3) (12)a. A 32-year-old woman presents to her primary
care physician's office with difficulty in
chewing of food. She complains that when
she eats certain foods that require a
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significant amount of chewing (meat), her jawmuscles become weak and "tired." After a
period of rest, her jaw muscles regain their
strength until she eats again. The patient was
diagnosed to be suffering from myasthenia
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gravis and started on neostigmine, anacetylcholinesterase (AChE) inhibitor. a) What
is myasthenia gravis? b) Discuss the
molecular theory of skeletal muscle
contraction. c)Describe the role of an
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acetylcholinesterase inhibitor in the treatmentof myasthenia gravis.
b. Anita a 40-year-old bank employee visited the
medicine OPD of a hospital with complaints of
(C/O), her colleagues pointed out that her
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physical appearance had been changing dayby day, her features had become coarse, She
had a protruding lower jaw with widely placed
teeth. She also added that she had suddenly
stopped menstruating for last 4 years ago;
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that her sandal & shoe, size had increasedalong with her fingers so that her rings no
longer fit. On physical examination she had-
Coarse facial features, prognathism, and
large hands and feet, Blood pressure was
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elevated at 170/110 mmHg Laboratoryfindings: Fasting s-glucose 250 mg/dL, fasting
blood growth hormone 90 ng/mL, IGF-I
elevated, FSH decreased, TSH normal, T4
normal, Prolactin elevated. She was
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diagnosed with Acromegaly. a) DiscussAcromegaly with an explanation of the
physiological basis of its sign and symptoms.
b) Enumerate the hormones secreted by the
anterior and posterior pituitary. c) What are
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somatomedins?c. Discuss the different contraceptives used in
females.
3. Write short notes (any 3 out of 4) (18)
a. Uterine changes in a female during the
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menstrual cycle.b. Liver function tests.
c. Composition of pancreatic juice and actions of
different enzymes present in it.
d. Spermatogenesis.
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4. Answer in only 2-3 sentence (any 5 out of6) (10)
a. The pain of appendicitis is initially felt in and
around the umbilicus. Why?
b. Basal body temperature of the female
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increases at the time of ovulation. Why?
c. Even after amputation of a limb, the patient
can sometimes feel pain in the amputated
limb. Why?
d. What is deglutition apnea?
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e. Barr's body is absent in a patient with Turnersyndrome. Why?
f. Role of L-dopa in treatment of Parkinson's
disease.
Section 2
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5. Write the following structured longquestion (any 1 out of 2) (10)
a. Enumerate the hormones secreted by the
adrenal cortex. Describe the functions of
glucocorticoids.
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b. Discuss the mechanism of secretion andfunctions of Insulin.
6. Write short notes (any 2 out of 3) (12)
a. Physiological properties of skeletal muscle.
b. Electrophysiological classification of nerves.
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c. Neuro-muscular transmission of nerveimpulses.
7. Write short notes (any 3 out of 4) (18)
a. Cholinergic receptors.
b. Parasympathetic chain of ganglia.
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c. Errors of refraction.d. Organ of Corti.
8. Answer in only 2-3 sentence (any 5 out of
6) (10)
a. The reason behind polydypsia in a patient
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with diabetes mellitus.b. Athletes' warm-up before any race. Why?
c. Which is the commonest type of color
blindness?
d. Signs and symptoms of Horner's syndrome
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are.e. Saltatory conduction is seen in which nerves?
f. What are the differences between a pituitary
dwarf and a thyroid dwarf (cretin)?