0422 E129
Second Year MBBS Examination
II MBBS Pathology Paper 1
Time: 3 hours
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Max Marks: 1001. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Structured Long Question (Any 1
out of 2)
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(10)a) Define necrosis describe various
types of necrosis, causes & pathology
of each type with Examples. Add a
note on wet gangrene.
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(1+3+4+2)b) List out the chemical mediators of
inflammation. Discuss in detail the role
of chemical mediators in acute
inflammation. Write differences
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between acute and chronicinflammation.
(2+5+3)
2. Case based scenario/Applied short
Notes (Any 2 out of 3)
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(12)a) A 42 year old man had history of
persistant cough and evening rise of
temperature over a period of 6 months
with associated loss of appetite and
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weight. On physical examinationmatted cervical lymphnodes were
found. X-ray chest reveals a small
radio opaque shadow in apex of upper
lobe of right lung. a) What is your
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probable diagnosis? b) Describepathogenesis & microscopic picture
seen with thislesion. c) Enumerate the
complications associated with this
lesion.
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b) A F/55 yr was brought to theemergency room unconscious. Her
blood pressure was very low, pulse
was weak and rapid. Her skin was
warm & flushed her blood culture
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revealed growth of gram positivebacteria. a) What is the possible
diagnosis? b)Describe the
pathogenesis and stages of this
condition.
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c) Chemotaxis3. Write short notes (Any 3 out of 4)
(18)
a) Write differences between
benign and malignant tumours.
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b) Name morphological types of
inflammation. Write in detail about
fibrinous inflammation.
c) Describe the fate of thrombus.
Write differences between antemortem
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thrombi and postmortem clots.d) A 55yr male had history of chest
pain for he which was admitted in
hospital, treated and discharged. At
second attack he was advised stents
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after angiogram for which he wasafraid. His father died because of
Myocardial infarction at 60 yrs of age.
a) Discuss the extent of patient
autonomy. b) Write the conflict
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between autonomy and beneficiance.4. Answer only in 2-3 sentences (Any
5 out of 6)
(10)
a) Write four examples of hyperplasia.
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b) Name four clinical features ofTurner syndrome.
c) Describe four modes of tumour
spread with examples.
d) Name four special stains to
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demonstrate amyloid.e) Morphological changes of
apoptosis.
f) Give four examples of immune
complex mediated type-reaction
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Section 25. Structured long question (Any 1
out of 2)
(10)
a) Classify hemolytic anemias. Write in
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detail about (3 thalassemia. Discuss
the laboratory diagnosis of
thalassemia.
(2+5+3)
b) Define and classify lymphoma.
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Discuss in detail about Hodgkinlymphoma. Write differentiating
features of Hodgkin's and Non
Hodgkin's lymphoma.
(3+5+2)
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6. Case based scenario / Appliedshort notes (Any 2 out of 3)
(12)
a) A 35 year old male was admitted
with history of progressive weakness
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with dragging sensation in left side ofthe abdomen. His Hb is 9.3 grams%;
TLC is 2,50,000 and platelet count is
3.8 lakhs/cumm.a)What is the
probable diagnosis.? b)What is the
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blood picture and molecularabnormality in this disease? c)Give
four causes of massive splenomegaly.
b) Write indications for blood
transfusion, What are blood
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components? Write in brief aboutsingle donor platelets.
c) FAB classification of Acute
myeloblastic leukemia. Write
peripheral smears findings of acute
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myeloblastic leukemia.7. Write short notes (Any 3 out of 4)
(18)
a) Peripheral smear and bone
marrow picture of megaloblastic
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anemia with diagram.b) Causes of pancytopenia and write
in brief about aplastic anemia.
c) Urinary casts.
d) Pathogenesis of viral
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carcinogenesis.8. Answer in 2-3 sentences (only 5
out of 6)
(10)
a) Osmotic fragility test
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b) Mention four effects of radiation.c) Name four inherited cancer
syndromes.
d) Name four autosomal dominant
diseases.
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e) Mention four causes ofDisseminated intravascular
coagulation.
f) Name any four myeloproliferative
disorders.
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