Download Gujarat University MBBS 2nd Year 0122 E490 Pharmacology Paper I Jan 2022 Question Paper

Date: 18-01-2022
0122 E490
Second Year MBBS Examination
II MBBS Pharmacology Paper 1
Time: 3 hours

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Max Marks: 100
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Answer any one of the following

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a) Classify Adrenergic drugs.
(10)
Mention the mechanism of action, adverse
drug reactions and uses for Adrenaline.
b) Define a "Receptor".

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[3+2+3+2=10]

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Classify various receptors providing
suitable examples of drugs acting through
them respectively.
[2+5+3=10]

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2. Answer Any Two of the following
a) A Schizophrenic patient of 51 yrs (12)
of age who was on antipsychotic
medications complaints of parkinson's
like tremors and dyskinesia. Explain the

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mechanism underlying the adverse drug
reaction and recommend which drugs to
be used to continue treating
schizophrenia.
b) A 40 year old gardener was brought by

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his wife to the hospital. His complaints
were of getting vomiting, abdominal colic,
diarrhoea, sweating, urination and
dyspnoea. He also gave the history of
spraying insecticide in the garden for 2

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hours daily for last week. Identify the
cause and describe how you will manage
the case.
c) A 35 year old epileptic patient was
prescribed tablet Phenytoin sodium by his

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neurologist. As a prescriber, mention the
instructions that you will give to the
patient regards appropriate administration
of the drug treatment.
3. Write Short Notes on Any Three of the

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following:
a) Therapeutic Drug Monitoring with (18)
drug examples requiring the same
b) Compare and contrast between
Barbiturates and Benzodiazepines

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c) Mention the adverse drug reactions for
Atropine
d) State the importance of Doctor-patient
communication with an example
4. Answer Any Five of the following

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briefly in 2 to 3 sentences
a) What is Hofmann's elimination?
(10)
Provide examples of drugs undergoing the
same.

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b) Give the uses for chlorpromazine
c) Describe the mechanism underlying
Succinylcholine [SCh] apnoea

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d) State the pharmacological basis of
using physostigmine in Dhathura

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poisoning
e) What are substances of abuse? Give
examples for the same
f) Mention about diagnostic use of
homatropine along with its mechanism

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Section 2
5. Answer any one of the following
a) Classify Angiotensin Converting
(10)
Enzyme inhibitors [ACEI], Describe their

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adverse drug reactions and therapeutic
uses.
[4+3+3=10]
b) Classify Anticoagulants. Mention the
mechanism of action, adverse drug

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reactions and indications for Heparin
6. Answer Any Two of the following
a) A 55 year old patient of
(12)
Hypertension with his B.P measuring

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170mm/120 mm Hg was given clonidine
by his physician. After 15 days the patient

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voluntarily discontinued his treatment and
was brought back to the hospital with
elevated blood pressure. State the reason

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and write about the management of this
condition.
b) A 50-yr old male presented with
complaints of severe pain & swelling of
right first metatarso-phalangeal joint

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[Rt.Great toe]X2 days. What is the likely
diagnosis and list the drags used to treat
this condition.
c) A patient of 45 years of age has
undergone total gastrectomy. Justify why

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the surgeon has advised him life long
parenteral vitamin B 12
7. Write Short Notes on Any Three of the
following:
a) Comment on the Fixed Dose

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(18)
Combination [FDC] of Atorvastatin
[I0mg] + Ezetimibe [IOmg]
b) Pharmacological basis of using
Salicylic acid with Benzoic acid in

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Whitfield's ointment

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c) Mention the adverse drug effects for
Thiazide diuretics
d) Enumerate the uses of Beta-blockers
8. Answer Any Five of the following

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briefly in 2 to 3 sentences.
a) State the drag and its mechanism (10)
regards causing Gray Baby syndrome in
Neonates
b) Describe the mechanism of action for

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Clopidogrel.
c) Mention the role of Cetrizine in a
factory worker suffering from allergic
rhinitis.
d) Give the rationale for using N-acetyl

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cysteine in Paracetamol [PCM] poisoning
e) State the pharmacological basis of
using Nifedipine as an anti-hypertensive
drug
f) Mention the adverse drug reactions

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noted with Oral Iron [Fe] formulations

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