Date: 02-02-2024
0224E638
Second Year MBBS Examination
II MBBS Pharmacology Paper 1
Time: 3 hours

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Max Marks: 100
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for

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each section.
4. Draw diagrams wherever
necessary.
5. Write legibly.
Section 1

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1. Answer any one (10)

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a) Classify B-blockers. Mention therapeutic
uses and adverse drug reaction of
Propranolol.:
(3+5+2=10)

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b) Classify Sedatives and Hypnotics.
Discuss briefly M.O.A, therapeutic uses
and adverse effect of Benzodiazepines.
(3+5+2=10)
2. Answer Any two of the

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following: (2x6=12)
(12)
a) A patient of severe episodic headache
with vomiting has attended to your clinic
and you have diagnosed her as severe

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migraine. What specific history will you
ask her before prescribing any drugs to
her? What drugs will you prescribe to her?
How will you communicate with the patient
after writing the prescription for her?

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b) A 62 years old male visited urology
department with complaints of frequent
need to urinate, difficulty in initiating
stream, and sense of incomplete voiding.

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On rectal examination increase in prostate

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size was detected. Benign prostate
hypertrophy was confirmed on
histopathological examination. Mention the
preferred drug for this patient. Write down
the mechanism of action and common

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side effect of this drug. What is the role of
finasteride in the treatment of BPH
c) A 15 year old boy was brought to
emergency with frequent convulsion,
tongue bite, and involuntary passage of

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urine. Patient party also gave history of
repeated such episodes. What is the
provisional diagnosis of such a case.
Enumerate the drugs useful to treat such
cases. Mention the newer drugs to treat

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epilepsy with their advantages.
3. Write Short Notes on Any three of the
following: (3x6=18)
(18)
a) Mechanism of action, adverse reaction

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& uses of Spironolactone.

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b) Explain why ethyl alcohol used in
methanol poisoning,
c) Plasma protein binding and its
significance.

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d) Clinical trail and its phases.
4. Answer Any Five of the following
briefly: (2x5=10)
(10)
a) Pharmacological basis for the use of

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carvedilol in CHF
b) Define tolerance & its type.
c) Mention any 2 centrally acting skeletal
muscle relaxants and its uses.
d) Mention the rationale of using

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Cinnarzine in vertigo..
e) Mention the treatment of Absence
Seizure. [P.?.0.
f) What are Pro-drugs. Give its Examples.

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Section 2

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5. Answer Any one of the following:
(2x6=12)
(10)
a) Describe the Pharmacological basis for
the use of Digoxin in CCF. Mention the

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adverse effect and therapeutic uses. Write
the role of digoxin in atrial flutter.
(3+5+2=10)
b) Describe the
Pharmacological basis for the use of

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Vasopressin in bleeding esophageal
Varices. Enumerate other antidiuretics and
mention their therapeutic uses.
(3+5+2=10)
6. Answer Any Two of the

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following: (2x6=12)
(12)
a) A 28 years old pregnant woman with 30
weeks gestation came with complaint of
swelling of right lower limb. On

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examination diagnosed as Deep Venous

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Thrombosis. Enumerate the drugs used in
this condition. Explain advantages of Low
Molecular Weight Heparins.
b) A 42 years old farmer was brought to

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casualty with symptoms of irritation of
eyes, lacrimation excessive salivation,
blurring of vision, breathlessness,
involuntary defecation and urination,
Based on these symptoms physician made

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a diagnosis of acute organophosphorous
compound poisoning. Discuss the
management of Organophosphorous
Poisoning. Enumerate the uses of
reversible anticholinesterases

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c) A 50 year old man visits his general
practitioner for routine health screening.
His blood pressure was 150/90 mm of Hg.
He has no other co-morbidities. He was
prescribed Ramipril. Explain the

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mechanism of action of Ramipril in this
patient? Enumerate the advantages and

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adverse effects of Ramipril.
7. Write Short Notes on Any Three of
the following: s (3x6-18).

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(18)
a) Biological response modifiers for
Rheumatoid Arthritis.
b) Role of Aspirin in Myocardial infarction.
c) Pharmacovigilance and its various

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activities under it.
d) Indications and adverse effects of oral
iron preparations.
8. Answer Any Five of the following
briefly: (2x5=10)

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(10)
a) Mention the rationale of combination of
Levodopa and Carbidopa in parkinsonism.
b) Explain why Rifampicin causes failure
of OCP&TMs

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c) Cheese reaction and its treatment.

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d) Explain why nitrate used in cyanide
poisoning.
e) Define volume of distribution and its
importance.

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f) Explain why Furosemide is used in
acute pulmonary oedema.

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