0321 E081
Second Year MBBS Examination
II MBBS Pharmacology Paper 1
Time: 2 hours
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Max Marks: 40Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Answer any one of the following
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(10)a) Classify Anti-tuberculosis drugs.
Mention the mechanism of action, adverse
drug reactions and uses for Rifampicin.
(4+2+2+2=10)
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b) Categorize differentAntimicrobials. Describe various
Mechanisms of action for antibiotics and
antimicrobials with suitable examples.
[5+3+2=10]
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2. Answer Any Two of thefollowing
(12)
a) A patient of 50 years of age was
prescribed tab Metronidazole by his
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physician. The recommended dose co himwas 400 mg thrice per day X 5 days. On
4th day in late evening the patient
attended a cocktail party with dinner in
celebration of his friends 50th birthday.
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Comment on outcome of this interactionand state management of this condition.
b) A 34 year old female patient who was
suffering from urinary infection was
prescribed Ciprofloxacin by her
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physician for the duration of 5 daysduration. On the 3rd day after taking the
morning dose around 11.00 am, as the
lady was going to her office, she noticed
reddish colour rash and itching on her
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body parts exposed to sunlight [face,neck, forearm & hand]. Comment on the
likely cause for the rash and describe
preventive as well as curative measures to
overcome the same in future.
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c) A women of 44 years of age visited adoctor's clinic with symptoms of fever,
headache and running nose. She was
diagnosed to be suffering from allergic
rhinitis and so was prescribed drugs
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Erythromycin along with Terfenadine byher doctor. Explain the consequence of
this drug interaction and the measures to
prevent it.
3. Write Short Notes on Any Three of the
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following:(18)
a) Mention the adverse drug effects and
uses for Ciprofloxacin.
b) Compare and contrast between
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Metronidazole and Mebendazole.c) State the mechanism of action and
indications for Chloroquine.
d) Describe the processes of development
of resistance to antimicrobials.
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4. Answer Any Five of the followingbriefly in 2 to 3 sentences
(10)
a) Give examples of antimicrobials that
are unsafe in pregnancy.
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b) State the pharmacological basis ofusing pyridoxine with Isonicotinic acid
[INH].
c) Mention antimicrobials that are
concentrated in prostate along with its
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significance.d) State the rationale of combining
Sulfamethoxazole and Trimethoprim in a
FDC.
e) Give the line of treatment of Lepra
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reaction.f) Mention the rationale of using
Ampicillin with Probenecid.
Section 2
5. Answer any one of the following
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(10)a) Classify Anti-diabetic drugs. Describe
the mechanism of action adverse drug
reactions (ADRs] and Indications for
Metformin.
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[4+4+2+2=10]b) Classify Anti-asthma drugs. Give the
mechanism of action, adverse drug
reactions and uses for Salbutamol
[3+3+2+2=10]
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6. Answer Any Two of thefollowing
(12)
a) A patient of 40 years old suffering from
moderate gastritis was prescribed tablet
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"Digene" brand containing Aluminiumhydroxide and Magnesium hydroxide. He
felt relieved after 2 days of treatment.
Comment on the rationality of drag
interaction regards the ingredient of the
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said tablet.b) A 37 year old patient presented to the
physician the complaints of
breathlessness and wheezing. This
symptoms use to also occur and
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aggravate during the night time and
interrupt his sleep. He was diagnosed to
be having moderate bronchial asthma.
Enumerate the drugs used in this patient
stating their respective mechanism of
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action. Also mention various dosageforms and devices used to administer the
drags for bronchial asthma.
c) State the contraceptive method that
you as a gynaecologist would recommend
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a newly married women of 25 years old.She is perfectly healthy and is interested
to plan her family.
7. Write Short Notes on Any Three of the
following:
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(18)a) Give the Source, mechanism of action
and and uses for Castor oil.
b) State the pharmacological basis of
combining estrogen with progestin in an
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Oral Contraceptive pill.c) Define a Liniment. Give the mechanism
of action & uses for Turpentine oil
liniment.
d) Mention 4 drugs with their respective
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formulation/s used in Ocularpharmacology.
8. Answer Any Five of the following
briefly in 2 to 3 sentences
(10)
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a) Write briefly on Tetanus toxoid.b) Mention the therapeutic role of
Omalizumab in bronchial asthma.
c) Differentiate between Purgatives and
Laxatives with examples.
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d) Describe briefly the merits anddemerits of Radioactive lodine.
e) State the properties of Calamine lotion.
f) Give the mechanism of action for
Metoclopramide.
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