0112 E3002
Second Year MBBS Examination
II MBBS Pharmacology Paper 1
Time: 2 hours
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Max Marks: 401. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.
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5. Write legibly.Section 1
1. Give an account of any TWO of the following
(10)
a) Define bioavailability. Explain the
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patient (biological) factors affectingbioavailability. (A.16,8. 12)
b) Explain the mechanism of action, clinical
uses and adverse effects of Mannitol. (A. 590,
. 550)
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c) Explain the mechanism of action, clinicaluses and adverse effects of Sodium valproate.
(A. 417,131)
2. Write Short notes of (any three)
(12)
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a) Explain the contraindications of propranolol(A. 146, . 277)
b) List important differences between
Barbiturates and Benzodiazepines (A. 401, B.
109)
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c) List the clinical uses of calcium channelBlockers (A. 550, B. 400)
d) Explain the clinical uses of reversible
Anticholinesterases (A. 108, . 287)
3. Discuss Any Three
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(12)a) Explain the clinical uses of Aspirin (A. 198,
B. 169)
b) Explain the management of status
asthmaticus (A. 233, B. 364)
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c) Explain the clinical uses of Prostaglandinanalogues (A. 189, B. 343)
d) Management of alcohol addicts (A. 393, B.
90)
4. Write Answer to the point in two or three
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sentences: (any six)
(6)
a) Define pharmacogenetics with two
examples. (A. 65, . 58)
b) Mention two alpha 1(a1) receptor stimulants
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and write two clinical uses. (A. 135, B. 257)c) Mention two atypical antipsychotic drugs
and write two advantages. (A. 441, . 195)
d) Explain the basis for using scopolamine in
motion sickness. (A. 113, B. 296)/Scopolamine
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is preferred over atropine for treatment ofmotion sickness.
e) Mention two uses and two specific adverse
effects of Nitroglycerine. (A. 542, . 436)
f) Explain the basis for combining
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Hydrochlorothiazide with Ramipril. (A. 504)g) Explain the basis for using Lignocaine in
ventricular tachy-arrhythmias. (A. 530, B. 381)
h) Mention two types of receptor antagonism
with one example for each. (A. 58, 38)
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