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D 23839 (Pages: 2) Name:...................
Reg. No:...................
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SECOND PROFESSIONAL M.B.B.S. DEGREE EXAMINATION, MARCH 2012
PHARMACOLOGY—Paper I
(2007 Admissions)
Time: Two Hours Maximum: 40 Marks
Answer all questions.
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Answer Section A and B in separate answer books.
Section A
I. Name the following:
(a) Prostaglandin analogue used in glaucoma.
(b) General anaesthetic (inhalational) which is preferred in paediatrics.
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(c) Catecholamine depletor which produces depression.
(d) Opioid analgesic given as transdermal patch.
(e) Monoclonal antibody used in asthma.
(f) Skeletal muscle relaxant preferred in cardiovascular instability. (6 x ½ = 3 marks)
II. Write the pharmacological basis for the use of following:
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(a) Enalapril in cardiac failure.
(b) Allopurinol in gout.
(c) Frusemide in acute pulmonary oedema.
(d) Dicyclomine in abdominal colic.
(e) Levodopa and Benserazide in Parkinsonism. (5 x 1 = 5 marks)
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III. Classify drugs used in the treatment of epilepsy based on their clinical use. Write the mechanism of action and adverse effects of Phenytoin. (3 + 1 + 2 = 6 marks)
IV. Write briefly on:
(a) Alcohol withdrawal syndrome.
(b) First pass metabolism.
(c) Ionodilators. (3 x 2 = 6 marks)
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2 D 23839
Section B
V. Read the case history and answer the questions:
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A 65 years old male was brought to the casualty with complaints of severe chest pain and sweating. ECG revealed ST segment elevation and was diagnosed as myocardial infarction.
(a) Which drug will you administer immediately in the casualty to relieve his pain? Give one important adverse effect on long term use.
(b) Mention the drug used to achieve reperfusion. Give two contraindications.
(c) Mention two advantages of using beta blockers.
(d) Which drug will you prescribe to prevent reinfarction? Why? (1½ + 1½ + 1 + 2 = 6 marks)
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VI. Mention the preferred drug with dose for the following:
(a) Insomnia.
(b) Ureteric colic.
(c) Iron deficiency anaemia in a pregnant lady.
(d) Dry cough in an adult. (4 x 1½ = 6 marks)
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VII. Write short notes on:
(a) Non cardiovascular uses of beta blockers.
(b) Antianxiety drugs.
(c) Drugs for hypertensive emergencies.
(d) Therapeutic index. (4 x 2 = 8 marks)
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