Download MBBS KUHS 2nd Year 2009 July Pharmacology Paper I Question Paper

FirstRanker.com

C 58011

SECOND PROFESSIONAL M.B.B.S. DEGREE EXAMINATION, JULY 2009

--- Content provided by‍ FirstRanker.com ---

PHARMACOLOGY-Paper I

Time: Two Hours Maximum: 40 Marks

Answer all questions.

Draw diagrams wherever necessary.

Answer Sections A and B in separate answer-books.

--- Content provided by⁠ FirstRanker.com ---

MCQs should be answered first in the response sheet provided.

Section A

1. Multiple Choice Questions. Single response type (separate sheet attached). (8 x ½ = 4 marks)
2. Match the following. Single response type (separate sheet attached). (8 x ½ = 4 marks)
3. Draw a schematic diagram of dopaminergic transmission and mark the site of action of:
   1. Carbidopa.

   --- Content provided by​ FirstRanker.com ---

   2. Selegiline. (1+½+½ = 2 marks)
4. What is the pharmacological basis for the use of
   1. Adrenaline with Lignocaine for tooth extraction.
   2. Aspirin in myocardial infarction.
   3. Indapamide in Hypertension.

   --- Content provided by‍ FirstRanker.com ---

   4. Sodium cromoglycate for allergic asthma. (4 x 1 = 4 marks)
5. Write short notes on:
   1. Preanaesthetic medication.
   2. Teratogenicity.
   3. Drug therapy of glaucoma. (3 x 2 = 6 marks)

   --- Content provided by‍ FirstRanker.com ---

Section B

VI. A 60 year old farmer, spraying pesticide in the field was brought to the casualty in an unconscious state. He was covered with urine, faeces, sweat and frothy sputum. His breathing was laboured and the pulse and B.P. were not recordable.

1. What are the above features due to ?
2. Name two groups of drugs used to treat this patient with one example each.

--- Content provided by FirstRanker.com ---

3. Explain the pharmacological basis for the use of the above drugs.
4. What advice can be given to prevent such accidents? (3+2+2+1 = 8 marks)

VII. Write two uses and two adverse effects each of:

1. Chlorpromazine.
2. Sodium valproate.

--- Content provided by‌ FirstRanker.com ---

3. Streptokinase.
4. Morphine. (4 x 1 = 4 marks)

VIII. Write short notes on:

1. Amiodarone.
2. Plasma expanders.

--- Content provided by⁠ FirstRanker.com ---

3. Succinyl choline.
4. Transdermal drug delivery systems.

PHARMACOLOGY-Paper I

I. MULTIPLE CHOICE QUESTIONS

Note.-(1) Do not write anything on the question paper.

--- Content provided by​ FirstRanker.com ---

(2) Write your register number on the answer-sheet provided.

(3) Select one most appropriate response and encircle the corresponding alphabet against each question in the answer-sheet provided

(4) In the response-sheet enter the total number of your answers in the appropriate box provided.

(5) Each question carries ½ mark..

1. Which of the following agents does not act through cytoplasmic receptors?
   1. Prednisolone.

   --- Content provided by‌ FirstRanker.com ---

   2. Calcitriol.
   3. Thyroxine.
   4. Insulin.
2. Which of the following is likely to lower the plasma levels of Theophylline ?
   1. Ritonavir.

   --- Content provided by‍ FirstRanker.com ---

   2. Ciprofloxacin.
   3. Phenytoin.
   4. Erythromycin.
3. General anaesthetic useful in a patient with hypotensive shock is:
   1. Halothane.

   --- Content provided by‍ FirstRanker.com ---

   2. Ketamine.
   3. Thiopentone.
   4. Midazolam.
4. Aumazenil can reverse the effects of all except :
   1. Alprazolam.

   --- Content provided by‌ FirstRanker.com ---

   2. Zolpidem.
   3. Thiopentone.
   4. Betacarboline.
5. Which of the following is useful in acute muscle spasm?
   1. Pancuronium.

   --- Content provided by FirstRanker.com ---

   2. Baclofen.
   3. Scoline.
   4. Dantrolene.
6. Which of the following is NOT effective in an acute attack of asthma ?
   1. Salmeterol.

   --- Content provided by​ FirstRanker.com ---

   2. Terbutaline.
   3. Theophylline.
   4. Formoterol.
7. Drug contraindicated in vasopastic angina is:
   1. Nifedipine.

   --- Content provided by​ FirstRanker.com ---

   2. Isosorbide dinitrate.
   3. Atenolol.
   4. Isosorbide mononitrate.
8. Cardiac remodelling can be reversed by all except:
   1. Captopril.

   --- Content provided by‌ FirstRanker.com ---

   2. Spironolactone.
   3. Digoxin.
   4. Atenolol (8 x ½ = 4 marks)

II. Match the following:

--- Content provided by​ FirstRanker.com ---

PHARMACOLOGY-Paper I

A. Drug with enzyme inhibited:

1. Disulfiram
2. Moclobemide
3. Warfarin

--- Content provided by​ FirstRanker.com ---

4. Amrinone

1. Vitamin K epoxide reductase.
2. Dopamine beta oxidase.
3. Monoamine oxidase.
4. Alcohol dehydrogenase.

--- Content provided by‍ FirstRanker.com ---

5. Phosphodiesterase.

B Drug with characteristic side effect:

1. Prilocaine
2. Fluoxetine
3. Frusemide

--- Content provided by‌ FirstRanker.com ---

4. Clozapine

1. Agronulocytosis.
2. Deafness.
3. Insomnia.
4. Methaemoglobinemia.

--- Content provided by​ FirstRanker.com ---

FirstRanker.com