Download MBBS KUHS 2nd Year 2009 July Pharmacology Paper II Question Paper

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SECOND PROFESSIONAL M.B.B.S. DEGREE EXAMINATION, JULY 2009

PHARMACOLOGY-Paper II

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Time: Two Hours Maximum: 40 Marks

Answer all questions.

Draw diagrams wherever necessary.

Answer Sections A and B in separate answer-books.

MCQs should be answered first in the response sheet provided.

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Section A

1. Multiple Choice Questions. Single response type (separate sheet attached). (8 x ½ = 4 marks)
2. Match the following. Single response type (Separate sheet attached). (8 x ½ = 4 marks)
3. Draw a schematic diagram of a gastric parietal cell and mark the site of action of (a) pantoprazole; (b) Famotidine. (1 + 1 = 2 marks)
4. Short answer questions:
   1. Explain sequential blockade with one example

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   2. Name four drugs used in lepra reaction.
   3. Explain leucovorin rescue.
   4. Mechanism of action of pioglitazone. (4 x 1 = 4 marks)
5. Write short notes on:
   1. Amphotericin -B.

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   2. Metronidazole.
   3. Treatment of Thyrotoxic crisis. (3 x 2 = 6 marks)

Section B

6. Ravi, 32 years, a truck driver developed fever, cough, malaise and weight loss. He was tested positive for TB and HIV.
   1. Name the anti TB drug effective against persistors. Write its mechanism of action and two other uses.

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   2. Name four drugs effective against MAC.
   3. List two advantages of DOTS.
   4. List four groups of drugs effective against HIV with one example each. (2 + 1 + 1 + 2 = 6 marks)
7. Choose the correct drug from the given pair and justify your choice.
   1. Benzyl Penicillin/Benzathine Penicillin for pneumonia.

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   2. Regular/Lente insulin for ketoacidosis.
   3. Dimeraprol/Desferrioxamine for iron poisoning.
   4. Praziquantel/Albendazole for neurocysticercosis. (4 x 1 = 4 marks)
8. Write short notes on:
   1. Bisphosphonates.

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   2. Superinfection.
   3. Vinca alkaloids.
   4. Cyclosporine.

PHARMACOLOGY-Paper II

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I. MULTIPLE CHOICE QUESTIONS

Note.-(1) Do not write anything on the question paper.

(2) Write your register number on the answer-sheet provided.

(3) Select one most appropriate response and encircle the corresponding alphabet against each question in the answer-sheet provided.

(4) In the answer-sheet enter the total number of your answers in the appropriate box provided.

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(5) Each question carries ½ mark.

1. Which of the following is NOT a bacterial cell wall synthesis inhibitor?
1. Capsofungin.
2. Cycloserine.
3. Carbenicillin.

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4. Ceftriaxone.
2. Chloroquine is effective in all except:
1. Gout.
2. Hepatic amoebiasis.
3. Lepra reaction.

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4. Scleroderma.
3. Renal elimination of Gentamicin parallels:
1. Urea.
2. Creatinine.
3. Uric acid.

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4. Potassium.
4. Anaerobes are not sensitive to:
1. Metronidazole.
2. Amikacin.
3. Penicillin.

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4. Chloramphenicol.
5. Drug of choice for CMV retinitis is:
1. Ganciclovir.
2. Acyclovir.
3. Idoxuridine.

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4. Amantadine.
6. Glove and stocking neuropathy is a characteristic side effect of:
1. Doxorubicin.
2. Paclitaxel.
3. Etoposide.

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4. l. asparaginase.
7. Which of the following is NOT an antiandrigen ?
1. Letrozole.
2. Danazol.
3. Ketoconazole

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4. Spironolactone.
8. Octreotide is used for all except:
1. Portal hypertension.
2. Insulinoma.
3. Glucagonoma.

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4. Cushing's syndrome. (8 x ½ = 4 marks)

PHARMACOLOGY-Paper II

II. Match the following: