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D 3704 (Pages: 2+1+1 = 4) Name......
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SECOND PROFESSIONAL M.B.B.S. DEGREE EXAMINATION, MARCH 2010
PHARMACOLOGY-Paper II
(New Scheme)
Time: Two Hours Maximum: 40 Marks
Answer all questions.
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Draw diagrams wherever necessary.
Answer Sections A and B in separate answer-books.
MCQ should be answered first in the response sheet provided.
Section A
I. Multiple Choice Questions. Single response type (separate sheet attached). (8 x ½ = 4 marks)
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II. Match the following. Single response type (separate sheet attached). (8 x ½ = 4 marks)
III. In a schematic diagram showing different phases of cell cycle, mark the sites of action of:
(a) Vincristine.
(b) Fluorouracil. (1+½+½ = 2 marks)
IV. Write short answers:
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(a) Mention four advantages of Azithromycin over Erythromycin.
(b) What are tocolytics? Give two examples.
(c) Name the glucocorticoid preferred in pregnant patient. Give the reason.
(d) What is lepra reaction? Name two drugs used to treat type II lepra reaction. (4 x 1 = 4 marks)
V. Write briefly on:
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(a) Desferrioxamine.
(b) Ciprofloxacin.
(c) Superinfections. (3 x 2 = 6 marks)
Section B
VI. A 45-year old male patient admitted with sputum positive tuberculosis. No history of previous anti-tuberculosis treatment.
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(a) Outline the treatment for this patient.
(b) Name the first line drugs used in tuberculosis. Which among them is not given orally? Why?
(c) Which first line drug is given only during initial phase of treatment? Give reason. Mention the adverse effects of this drug.
Turn over
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(d) Which first line drug is effective against persisters? How does it act? Mention four other uses of this drug. (4 x 2 = 8 marks)
VII. Give the rationale for the following:
(a) Chloroquine + Primaquine in malaria.
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(b) Tamoxifen in carcinoma breast.
(c) Sulfasalazine in ulcerative colitis.
(d) Methotrexate + Folinic acid in choreo carcinoma. (4 x 1 = 4 marks)
VIII. Write short notes on:
(a) Metronidazole.
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(b) Proton pump inhibitors.
(c) Bisphosphonates.
(d) Insulin sensitizers. (4 x 2 = 8 marks)
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PHARMACOLOGY-Paper II
I. MULTIPLE CHOICE QUESTIONS
Note.-(1) Do not write anything on the question paper.
(2) Write your register number on the answer-sheet provided.
(3) Select the most appropriate response and encircle the alphabet in the answer sheet provided.
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(4) In the answer-sheet enter the total number of your answers in the appropriate box provided.
(5) Each question carries ½ mark.
1. All the following are antiemetics except:
(A) Apomorphine. (B) Metoclopramide.
(C) Chlorpromazine. (D) Ondansetron.
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2. Which drug is ineffective against anaerobes?
(A) Chloramphenicol. (B) Cefoxitin.
(C) Ciprofloxacin. (D) Clindamycin.
3. Which is a teratogenic antimicrobial?
(A) Penicillin G. (B) Erythromycin.
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(C) Gentamicin. (D) Aztreonam.
4. All the following are nephrotoxic except:
(A) Cisplatin. (B) Amphotericin B.
(C) Vancomycin. (D) Chloramphenicol.
5. Anthelmintic that causes spastic paralysis of the worm is:
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(A) Piperazine. (B) Pyrantel pamoate.
(C) Praziquantel. (D) Benznidazole.
6. Drug of choice for cytomegalovirus induced retinitis is:
(A) Acyclovir. (B) Ganciclovir.
(C) Idoxuridine. (D) Ribavirin.
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7. All the following are adverse effects of corticosteroids except:
(A) Hypertension. (B) Cataract.
(C) Hyperglycaemia. (D) Hyperkalaemia.
8. Which is a DMARD?
(A) Infliximab. (B) Prednisolone.
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(C) Etoricoxib. (D) D-Penicillamine. (8×½ = 4 marks)
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D 3704 PHARMACOLOGY-Paper II
II. Match the following:
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A. Match for antimicrobial spectrum:
1 Fluconazole (a) Chlamydiae.
2 Albendazole (b) Candida albicans.
3 Doxycycline (c) Toxoplasma.
4 Clindamycin (d) Pseudomonas.
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(e) Echinococcus granulosus.
B. Match for adverse effect:
1 Cyclosporine (a) Pancreatitis.
2 Doxorubicin (b) Hypokalaemia.
3 Didanosine (c) Gum hypertrophy.
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4 Chlorpropamide (d) Cardiomyopathy.
(e) Cholestatic Jaundice. (8 x ½ = 4 marks)
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