Download DM 2020 D.M. (Clinical Haematology) 161401 Structure and function of the Hemopoietic system molecular biology and Genetic aspects of Haemopoiesis Question Paper

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SYSTEM MOLECLULAR BIOLOGY AND GENETIC
ASPECTS OF HAEMOPOIESIS
Q.P. Code: 161401

Time: Three Hours Maximum: 100 Marks

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I. Elaborate on: (2 x 15 = 30)

1. Describe normal pathway of heme synthesis and its relevance in
hematology.

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2. Describe in detail the current understanding of the mechanisms of
resistance to tyrosine kinase inhibitors in chronic myeloid leukemia
and strategies that could potentially overcome it.

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II. Write notes on: (10 x 7 = 70)

1. Myeloid derived suppressor cells.
2. Gamma delta T cells.
3. Targeting the microenvironment in chronic lymphocytic leukemia.

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4. Mixed chimerism post stem cell transplantation in nonmalignant
hematological diseases.
5. Normal metabolism of Arsenic trioxide.
6. Wnt signaling pathway.
7. Molecular biology of stem cell homing.

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8. Warburg phenomenon.
9. Post transcriptional regulation.
10. Somatic uniparental disomy.

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