Download DM 2020 D.M. (Clinical Haematology) 161401 Structure and function of the Hemopoietic system molecular biology and Genetic aspects of Haemopoiesis Question Paper

Download DM (Doctorate of Medicine) 2020 D.M. (Clinical Haematology) 161401 Structure and function of the Hemopoietic system molecular biology and Genetic aspects of Haemopoiesis Previous Question Paper

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(LQ 064) FEBRUARY 2020 Sub. Code: 1401

D.M. ? CLINICAL HAEMATOLOGY
Paper I ? STRUCTURE AND FUNCTION OF THE HEMOPOIETIC
SYSTEM MOLECLULAR BIOLOGY AND GENETIC
ASPECTS OF HAEMOPOIESIS
Q.P. Code: 161401

Time: Three Hours Maximum: 100 Marks

I. Elaborate on: (2 x 15 = 30)

1. Describe normal pathway of heme synthesis and its relevance in
hematology.

2. Describe in detail the current understanding of the mechanisms of
resistance to tyrosine kinase inhibitors in chronic myeloid leukemia
and strategies that could potentially overcome it.

II. Write notes on: (10 x 7 = 70)

1. Myeloid derived suppressor cells.
2. Gamma delta T cells.
3. Targeting the microenvironment in chronic lymphocytic leukemia.
4. Mixed chimerism post stem cell transplantation in nonmalignant
hematological diseases.
5. Normal metabolism of Arsenic trioxide.
6. Wnt signaling pathway.
7. Molecular biology of stem cell homing.
8. Warburg phenomenon.
9. Post transcriptional regulation.
10. Somatic uniparental disomy.


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