Download DM 2020 D.M. (Clinical Haematology) 161404 Recent Advances in Haematology Question Paper

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Q.P. Code: 161404

Time: Three Hours Maximum: 100 Marks

I. Elaborate on: (2 x 15 = 30)

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1. Discuss the recent changes in the WHO 2016 criteria for diagnosis of
myeloproliferative neoplasms.

2. Discuss the diagnosis and relevance of Philadelphia like acute

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lymphoblastic leukemia. Also discuss potential strategies to treat these
conditions.

II. Write notes on: (10 x 7 = 70)

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1. Anti-Leukemia Activity of the Selective BCL-2 Inhibitor ABT-199.
2. Role of hypo-methylating agents in high risk young adults with acute
myeloid leukemia.
3. Thrombopoeitin receptor agonists and aplastic anemia.
4. Liposomal CPX-351 in acute myeloid leukemia.

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5. Targeting microenvironment in leukemia.
6. Artesunate in the management of cytomegalovirus infection.
7. Gene editing strategies.
8. Potential role of Pioglitazone in the management of chronic myeloid
leukemia.

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9. Potential role and rationale of IL2 in management of acute graft versus
host disease.
10. Nontransplant therapy in aplastic anemia.

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