Download MBBS TMU 1st Year 2016 MBS103A Biochemistry I Question Paper

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) TMU (Teerthanker Mahaveer University) First Year (1st Year) 2016 MBS103A Biochemistry I Previous Question Paper

MBBS I (First) Professional Examination 2015-16

Course Code: MBS103 Paper ID: 0322208

Biochemistry -I

Time: 2 Hours 40 Minutes

Max Marks: 40

Note: Attempt all questions. Draw proper diagrams to support

your answer.

Part `B'

1.

Write short notes on: (2x5=10)

a)

Glycolysis

b)

Transamination

c)

Allosteric enzymes

d)

Phospholipids

e)

HDL-cholesterol

2.

Discuss: (4x3=12)

a)

Enzyme profile in MI(myocardial infarection)

b)

von Gierke's disease

c)

Diagnosis of diabetes mellitus

d)

Biochemical role of tryptophan

3.

Explain the following: (2x4=8)

a)

Primary & secondary Gout

b)

Regulation of gluconeogenesis

4.

Write in detail: (5x2=10)

a)

Sources & fate of acetyl CoA

b)

Fatty Liver



MBBS I (First) Professional Examination 2015-16

Roll No.

Student's Name



Student's Signature

Invigilator's Signature



Course Code:MBS103



Paper ID: 0322208

Biochemistry - I

Part `A'



Time: 20 Minutes

Max Marks: 10

Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.
2. Please tick () correct one only. Cutting, overwriting or any other marking are not allowed.
3. For answering please use Ball- pen only.


b)

Soluble, colloidal, protein

Q.1

All the following activities are taking place

molecules

inside mitochondria except:

c)

Structural analogue of enzymes

a)

Citric acid cycle

d)

Different forms of enzymes

b)

Electron transport chain

c)

oxidation of fatty acid

Q.9

The isoenzymes of LDH:

d)

De novo fatty acid synthesis

a)

Differ only in a single amino acid

b)

Differ in catalytic activity

Q.2

Erythrocyte glucose transporter is an

c)

Exist in 5 forms depending on M

example of:

and H monomer contents



a. Facilitated diffusion

d)

Occur as monomers

b. Ion driven active transport
c. Active transport

Q.10 Lineweaver ? Burk double reciprocal plot is

d. Simple diffusion

related to:
a)

Substrate concentration

Q.3

Which is the non essential amino acid:

b)

Enzyme activity

a)

Tyrosine

c)

Temperature

b)

Lysine

d)

Both (A) and (B)

c)

Valine



d)

Phenyl alanine

P.T.O.
Q.11 Osazones are not formed with the:

Q.4

All of the following hormones have

a)

Glucose

membrane receptors except:

b)

Fructose

a)

Insulin

b)

Epinephrine

c)

Sucrose

c)

Glucagon

d)

Thyroxine

d)

Lactose

Q.5

In sickle cell anemia the genetic defect is:

Q.12 Which one of the following statements

a)

replacement of glutamic acid by

concerning glucose metabolism is correct:

valine in chain of Hb

a)

The conversion of Glucose to

b)

replacement of valine by glutamic

lactate occurs only in the R.B.C

acid in chain of Hb

b)

Glucose enters most cells by a

c)

replacement of aspartic acid by

mechanism in which Na+ and

valine in chain of Hb

glucose are co- transported

d)

replacement of valine by aspartic

c)

Pyruvate kinase catalyses an

acid in chain of Hb

irreversible reaction

d)

An elevated level of insulin leads to

Q.6

Which contains copper:

a decreased level of fructose 2, 6-

a)

Cytochrome oxidase

bisphosphate in hepatocyte

b)

Cytochrome b5

Q.13 HMP Shunt pathway is important for all the

c)

Coenzyme Q

following except:

d) Cytochrome P450

a)

Generation of ATP

b)

Fatty acid biosynthesis

Q.7

In enzyme kinetics Km implies:

c)

Synthesis of reduced glutathione

a)

The substrate concentration that

d)

Synthesis of ribose

gives one half Vmax

b)

The dissocation constant for the

Q.14 The 2 nitrogen atoms in urea are

enzyme substrate comples

contributed by:

c)

Concentration of enzyme

a)

Ammonia and glutamate

d)

Half of the substrate concentration

b)

Glutamine and glutamate

required to achieve Vmax

c)

Ammonia and aspartate

Q.8

Coenzymes are:

d)

Ammonia and alanine

a)

Heat stable, dialyzable, non protein
organic molecules

Q.15 Tryptophan could be considered as

precursor of:
a)

Melatonin

b)

Thyroid hormones

c)

Melanin

d)

Epinephrine

Q.16 All of the following enzymes are secreted

as proenzymes except:
a)

Trypsin

b)

Chymotrypsin

c)

Pepsin

d)

Ribonuclease

Q.17 Cholesterol is transported from liver to

extrahepatic tissues by:
a)

Chylomicrons

b)

VLDL

c)

HDL

d)

LDL

Q.18 Adipose tissue lacks:

a)

Hormone-sensitive lipase

b)

Glycerol kinase

c)

cAMP-dependent protein kinase

d)

Glycerol-3-phosphate
dehydrogenase

Q.19 Carnitine is required for the transport of:

a)

Triglycerides out of liver

b)

Triglycerides into mitochondria

c)

Short chain fatty acids into
mitochondria

d)

Long chain fatty acids into
mitochondria

Q.20 . Lesch-Nyhan syndrome, the sex linked

recessive disorder is due to the lack of the
enzyme:
a)

Hypoxanthine-guanine
phosphoribosyl transferse

b)

Xanthine oxidase

c)

Adenine phosphoribosyl transferase

d)

Adenosine deaminase