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Download MBBS TMU 2nd Year 2017 MBS203 Pharmacology I Question Paper

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) TMU (Teerthanker Mahaveer University) Second Year (2nd Year) 2017 MBS203 Pharmacology I Previous Question Paper

This post was last modified on 17 February 2022

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MBBS II (Second) Professional Examination 2016-17

Course Code: MBS203

Paper ID: 0322410

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Pharmacology-I

Time: 2 Hours 40 Minutes

Max Marks: 30

Note: Attempt all questions. Draw proper diagrams to support your answer.

Part 'B'

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  1. Describe Enzyme Induction and Enzyme inhibition and explain its clinical relevance. (7)

  2. A 25 yrs old male patient attended the emergency with the c/o sever breathlessness with cough and wheezing, after clinical examination and investigation he was diagnosed as a case of severe acute bronchial asthma.

    1. Classify the drugs used in bronchial asthma. (2)

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    2. Write the t/t of status asthmatics. (2)

    3. Write the MOA, uses and ADRs of Inhalational Corticosteroids in bronchial asthma. (3)

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  3. Explain the Pharmacological basis for the use of:

    -----:

    (8)

    1. Neostigmine in Myasthenia gravis
    2. Levodopa with Carbidopa in Parkinsonism

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    3. Tamsulosin in Benign prostatic Hypertrophy
    4. Atropine in Organophosphate Compound poisoning

  4. Write short notes on:

    (2x4=8)

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    1. Treatment of open angle glaucoma
    2. Atypical antipsychotics
    3. Newer antiepileptics
    4. Proton pump inhibitors

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Roll No.

MBBS II (Second) Professional Examination 2016-17

Student's Signature

Course Code: MBS203

Time: 20 Minutes

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Pharmacology-I

Part 'A'

Student's Name

Invigilator's Signature

Paper ID: 0322410

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Max Marks: 10

Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.

2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed.

3. For answering please use Ball- pen only.

  1. Q.1 Majority of drugs cross biological membranes primarily by:

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    1. Passive diffusion
    2. Facilitated diffusion
    3. Active transport
    4. Pinocytosis

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  2. Q.2 High plasma protein binding:

    1. Increase volume of distribution of the drug
    2. Facilitates glomerular filtration of the drug
    3. Generally makes the drug long acting
    4. Minimizes drugs interaction

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  3. Q.3 If a drug is eliminated by first order kinetics:

    1. A constant amount of the drug will be eliminated per unit time
    2. Its clearance value will remain constant
    3. Its elimination half life will increase with dose

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    4. It will be completely eliminated from the body in 2 x half life period

  4. Q.4. Autacoids differ from hormones in that:

    1. Autacoids are involved only in the causation of pathological states
    2. Autacoids do not have a specific cell / tissue of origin

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    3. Autacoids generally act locally at the site of generation and release
    4. Both 'B' and 'C' are correct

  5. Q.5 High anticholinergic property is present in the following antihistaminic:

    1. Diphenhydramine

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    2. Astemizole
    3. Cetirizine
    4. Terfenadine

  6. Q.6 The following is a selective 5HT1B / ID receptor agonist:

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    1. Buspirone
    2. Ondansetron
    3. Sumatriptan
    4. a- methyl 5-HT

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  7. Q.7 Select the receptor that is located intracellularly:

    1. Opioid u receptor
    2. Steroid receptor
    3. Prostaglandin receptor
    4. Angiotensin receptor

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  8. Q.8 The following eicosanoid is generated through the lipoxygenase pathway:

    1. Prostaglandin E2
    2. Thromboxane A2
    3. Leukotriene C4.

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    4. Prostacyclin

  9. Q.9 Mucokinetic is a drug which:

    1. Reduces airway mucus secretion
    2. Increases airway mucus secretion

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    3. Makes respiratory secretions more watery
    4. Stimulates mucociliary activity of bronchial epithelium

  10. Q.10 Dextromethorphan is an:

    1. Analgesic

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    2. Antitussive
    3. Expectorant
    4. Antihistaminic

  11. Q.11 Dissociative anaesthesia is produced by:

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    1. Ketamine
    2. Etomidate
    3. Propofol
    4. Thiopentone

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  12. Q.12 Systemic corticosteroids are indicated in the following conditions except:

    1. Mild episodic asthma
    2. Severe chronic asthma
    3. Status asthmaticus
    4. To prevent neonatal respiratory distress syndrome

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  13. Q.13 Dobutamine differs from dopamine in that:

    1. It does not activate peripheral dopaminergic receptors
    2. It does not activate adrenergic β receptor
    3. It cause pronounced tachycardia

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    4. It has good blood brain barrier penetrability

  14. Q.14 Nonsteroidal anti-inflammatory drugs reduce the diuretic action of furosemide by:

    1. Preventing prostaglandin mediated intrarenal haemodynamic actions
    2. Blocking the action in ascending limb of loop of Henle

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    3. Enhancing salt and water reabsorption in distal tubule
    4. Increasing aldosterone secretion

  15. Q.15 The bladder trigone and prostatic muscles are relaxed by:

    1. Adrenergic α₁ agonists

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    2. Adrenergic α₁ antagonists
    3. Adrenergic α₂ agonists
    4. Adrenergic α₂ antagonists

  16. Q.16 Dorzolamide is a:

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    1. Topically applied ocular carbonic anhydrase inhibitor
    2. Second generation sulfonylurea hypoglycemic
    3. Topical sulfonamide antibacterial
    4. Luminal amoebicide

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  17. Q.17 True about Benzodiazepines as compared to Barbiturates is:

    1. Alter sleep pattern more than Barbiturates
    2. No antidote is available
    3. Overdose is better tolerated
    4. More sedative than Barbiturates

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  18. Q.18 Decrease in responsiveness to a drug which develops rapidly within a few minutes:

    1. Refractoriness
    2. Cumulative effect
    3. Tolerance

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    4. Tachyphylaxis

  19. Q.19 Which of the following is a tricyclic antidepressant:

    1. Fluoxetine
    2. Amitriptyline

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    3. Moclobemide
    4. Fluvoxamine

  20. Q.20 Prodrug among the following:

    1. Labetalol

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    2. Clonidine
    3. Enalapril
    4. Nifedipine

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This post was last modified on 17 February 2022