Download MBBS TMU 2nd Year 2017 MBS203 Pharmacology I Question Paper

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) TMU (Teerthanker Mahaveer University) Second Year (2nd Year) 2017 MBS203 Pharmacology I Previous Question Paper

MBBS II (Second) Professional Examination 2016-17


Course Code:MBS203

Paper ID: 0322410



Pharmacology-I


Time: 2 Hours 40 Minutes



Max Marks: 30


Note: Attempt all questions. Draw proper diagrams to support


your answer.









Part `B'



1.

Describe Enzyme Induction and Enyzme inhibition and
explain its clinical relevance. (7)


2.

A 25 yrs old male patient attended the emergency with the
c/o sever breathlessness with cough and wheezing, after
clinical examination and investigation he was diagnosed as
a case of severe acute bronchial asthma.

a) Classify the drugs used in bronchial asthma. (2)
b) Write the t/t of status asthmatics. (2)
c) Write the MOA, uses and ADRs of Inhalational

Corticosteroids in bronchial asthma. (3)


3.

Explain the Pharmacological basis for the use of: ------------
-----: (8)

a) Neostigmine in Myasthenia gravis
b) Levodopa with Carbidopa in Parkinsonism
c) Tamsulosin in Benign prostatic Hypertrophy
d) Atropine in Organophosphate Compound poisoning

4.

Write short notes on: (2x4=8)

a) Treatment of open angle glaucoma
b) Atypical antipsychotics
c) Newer antiepileptics
d) Proton pump inhibitors




MBBS II (Second) Professional Examination 2016-17



Roll No.















Student's Name







Student's Signature











Invigilator's Signature










Course Code:MBS203











Paper ID: 0322410

Pharmacology-I



Part `A'




Time: 20 Minutes

















Max Marks: 10


Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.
2. Please tick () correct one only. Cutting, overwriting or any other marking are not allowed.
3. For answering please use Ball- pen only.





Q.1

Majority of drugs cross biological

c)

Autacoids generally act locally at

membranes primarily by:

the site of generation and release

a)

Passive diffusion

d)

Both `B' and `C' are correct

b)

Facilitated diffusion



c)

Active transport

Q.5

High anticholinergic property is present in

d)

Pinocytosis

the following antihistaminic:



a)

Diphenhydramine

Q.2

High plasma protein binding:

b)

Astemizole

a. Increase volume of distribution of the

c)

Cetirizine

drug

d)

Terfenadine

b. Facilitates glomerular filtration of the



drug

Q.6

The following is a selective 5HT1B / ID

c. Minimizes drugs interactions

receptor agonist:

d. Generally makes the drug long acting

a)

Buspirone



b)

Ondansetron

Q.3

If a drug is eliminated by first order

c)

Sumatriptan

kinetics:

d)

- methyl 5 ?HT

a)

A constant amount of the drug will





be eliminated per unit time

Q.7

Select the receptor that is located

b)

Its clearance value will remain

intracellularly:

constant

a)

Opioid receptor

c)

Its elimination half life will increase

b)

Steroid receptor

with dose

c)

Prostaglandin receptor

d)

It will be completely eliminated

d)

Angiotensin receptor

from the body in 2 x half life period


Q.8

The following eicosanoid is generated



through the lipoxygenase pathway:

Q.4. Autacoids differ from hormones in that:

a)

Prostaglandin E

a)

Autacoids are involved only in the

2

b)

Thromboxane A

causation of pathological states

2

c)

Leukotriene C

b)

Autacoids do not have a specific

4.

d)

Prostacyclin

cell / tissue of origin









P.T.O.
Q.9

Mucokinetic is a drug which:

Q.16 Dorzolamide is a:



a)

Reduces airway mucus secretion

a)

Topically applied ocular carbonic



b)

Increases airway mucus secretion

anhydrase inhibitor

c)

Makes respiratory secretions more

b)

Second generation sulfonylurea

watery

hypoglycemic

d)

Stimulates mucociliary activity of

c)

Topical sulfonamide antibacterial

bronchial epithelium

d)

Luminal amoebicide





Q.10 Dextromethorphan is an:

Q.17 True about Benzodiazepines as compared

a)

Analgesic

to Barbiturates is:



b)

Antitussive

a)

Alter sleep pattern more than

c)

Expectorant

Barbiturates

d

Antihistaminic

b)

No antidote is available



c)

Overdose is better tolerated


Q.11 Dissociative anaesthesia is produced by:

d)

More sedative than Barbiturates

a)

Ketamine



b)

Etomidate

Q.18 Decrease in responsiveness to a drug which

c)

Propofol

develops rapidly within a few minutes:

d)

Thiopentone



a)

Refractoriness



b)

Cumulative effect

Q.12 Systemic corticosteroids are indicated in

c)

Tolerance

the following conditions except:



d)

Tachyphylaxis







a)

Mild episodic asthma

Q.19 Which of the following is a tricyclic

b)

Severe chronic asthma

antidepressant:



c)

Status asthmaticus



a)

Fluoxetine



d)

To prevent neonatal respiratory

b)

Amitriptyline

distress syndrome

c)

Moclobemide



d)

Fluvoxamine

Q.13 Dobutamine differs from dopamine in that:



a)

It does not activate peripheral

Q.20 Prodrug among the following:

dopaminergic receptors



a)

Labetalol

b)

It does not activate adrenergic ?

b)

Clonidine

receptor

c)

Enalapril



c)

It cause pronounced tachycardia



d)

Nifedipine

d)

It has good blood ? brain barrier



penetrability


Q.14 Nonsteroidal

anti-inflammatory

drugs

reduce the diuretic action of furosemide by:
a)

Preventing prostaglandin mediated
intrarenal haemodynamic actions

b)

Blocking the action in ascending
limb of loop of Henle

c)

Enhancing

salt

and

water

reabsorption in distal tubule

d)

Increasing aldosterone secretion


Q.15 The bladder trigone and prostatic muscles

are relaxed by:
a)

Adrenergic 1 agonists

b)

Adrenergic 1 antagonists

c)

Adrenergic 2 agonists

d)

Adrenergic 2 antagonists