Download MBBS TMU 2nd Year 2016 MBS201A Pathology I Question Paper

MBBS II (Second) Professional Examination 2015-16

Course Code: MBS201

Paper ID: 0322401

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Pathology-I

Time: 2 Hours 40 Minutes

Max Marks: 30

Note: Attempt all questions. Draw proper diagrams to support your answer.

Part 'B'

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1. A 60 years old male presented with fatigue, weight loss and heaviness in left hypochordrium for 6 months. The hemogram showed Hb 10 gm/dl. TLC 5 lakhs/mm³. DLC- neutrophils 55%, lymphocytes 4%, monocytes 2%, basophils 6% metamyelocytes 10%, myelocyte 18%, promyelocytes 2% and blasts 3%.

   1. What is the diagnosis? (1)
   2. Discuss the cytogenetic abnormality of the disease. (2)
   3. Draw and describe the peripheral smear findings in detail. (2)
   4. Discuss in brief the natural history of disease. (2)

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2. Define embolism. Enumerate the type of Emboli and discuss their pathophysiology. (7)

3. Write short notes: (2x4=8)

   1. Tumor Markers

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   2. Classification of Leukemia
   3. DIC
   4. Type I hypersensitivity reaction

4. Differentiate between:

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   1. Necrosis and apoptosis
   2. Exudate and transudate. (4+4)

Roll No.

MBBS II (Second) Professional Examination 2015-16

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Student's Signature

Course Code: MBS201

Time: 20 Minutes

Pathology-I

Part 'A'

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Student's Name

Invigilator's Signature

Paper ID: 0322403

Max Marks: 10

Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.

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2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed.

3. For answering please use Ball- pen only.

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1. HLA antigens are located on:
   1. On all nucleated cells of the body
   2. B & T lymphocytes
   3. Macrophage
   4. Complement system

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2. In amyloidosis Beta pleated sheet will be seen in:
   1. X-ray crystallography
   2. Electron microscope
   3. Spiral electron microscope
   4. Congo red stain

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3. Which among the following is NOT an autoimmune disease:
   1. Myasthenia gravis
   2. Systemic lupus erythematosus
   3. Grave's disease
   4. Sickle cell disease

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4. Which of the complement component act as chemokines:
   1. C3b
   2. C4b
   3. C5a
   4. C4a

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5. Grading of tumors depend upon:
   1. Degree of anaplasia
   2. Metastatic spread
   3. Rate of growth of cells
   4. Degree of differentiation

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6. Which of the following viral infection is not known to produce any tumor:
   1. Polyoma virus
   2. EBV
   3. HSV
   4. HTLV

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7. Which one of the following is not used as a tumor marker in testicular tumours:
   1. AFP
   2. LDH
   3. HCG
   4. CEA

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8. Teratogens are defined as agents which induce:
   1. Mitosis
   2. Carcinogenesis
   3. Birth defect
   4. Fallot's tetralogy

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9. Class of anemia is defective in following except:
   1. Spherocytosis
   2. Ovalocytosis
   3. Leptocytosis
   4. Echinocytosis

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10. Erythroid cells continue to proliferate upto the stage of:
    1. Reticulocytes
    2. Late normoblast
    3. Intermediate normoblast
    4. Early normoblast

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11. Which of the following statements about carcinogenesis is false:
    1. Asbestos exposure increase the incidence of lung cancer
    2. Papilloma viruses produce tumours in animals but not in humans
    3. Exposure to aniline dyes predisposes to cancer of the urinary bladder
    4. Hepatitis B virus has been implicated in hepatocellular carcinoma

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12. One of the following stains is specific for Amyloid:
    1. Periodic Acid Schiff (PAS)
    2. Alizarin red
    3. Congo red
    4. Von-Kossa

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13. Cold agglutinin antibody in autoimmune hemolytic anemia affects:
    1. Mature erythrocyte
    2. Reticulocytes
    3. Siderocytes
    4. Late erythroblast

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14. Which of the following is not included in TTP triad:
    1. Thrombocytopenia
    2. DIC
    3. Microangiopathic haemolytic anaemia
    4. Fibrin microthrombi

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15. Leucocyte alkaline phosphatase (LAP) score are elevated in:
    1. AML
    2. CML
    3. Myeloid metaplasia
    4. Myeloid leukaemoid reaction

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16. Leukaemic stage of cutaneous T cell lymphoma is called:
    1. Hairy cell leukemia
    2. Adult T cell leukemia
    3. Mycosis fungoides
    4. Sezary syndrome

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17. Isotretinoin treatment is effective in which acute leukemia:
    1. ALL
    2. AML - M2
    3. AML - M6
    4. AML - M3

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18. Gum hypertrophy is feature of the following FAB type AML:
    1. FAB- M1
    2. FAB - M2
    3. FAB - M3
    4. FAB - M4

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