DNB 2019 Dec Previous Question Papers-(Diplomate of National Board) Under NBE
FINAL EXAM
DECEMBER 2019
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Time: 3 hours
BIOCHEMISTRY
PAPER-III
Max. Marks:100
Important Instructions:
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- Attempt all questions in order.
- Each question carries 10 marks.
- Read the question carefully and answer to the point neatly and legibly.
- Do not leave any blank pages between two answers.
- Indicate the question number correctly for the answer in the margin space.
- Answer all the parts of a single question together.
- Start the answer to a question on a fresh page or leave adequate space between two answers.
- Draw table/diagrams/flowcharts wherever appropriate.
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NATIONAL BOARD OF EXAMINATIONS
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BCHEM/D/19/03/11
Write short notes on:
- What is Cell mediated immunity and Humoral immunity? What are paraproteins? Write its clinical significance. (5+3+2)
- a) Biochemical effects of tumour growth. (5)
b) Consequences of cancer treatment. (5) - Enumerate the causes of DNA damage and repair mechanisms. What are clinical significance/manifestations of defective DNA repair mechanisms? (5+5)
- What is the effect on the Lactose operon of a mutation that inactivates adenylate cyclase? Add a note on Mobile DNA elements. (6+4)
- Enlist the different types of ROS (Reactive oxygen species) affecting human health. How are they generated/produced? Enumerate three enzymes acting/combating as scavengers. (3+4+3)
- a) What are Proto-oncogenes and oncogenes with examples? (3)
b) Mention important growth factors. (4)--- Content provided by FirstRanker.com ---
c) List three commonly used Tumor markers and its clinical uses. (3) - Describe cloning of human DNA in bacteria using Recombinant DNA technology. Briefly describe about DNA library. (6+4)
- What is Restriction Fragment Length Polymorphism (RFLP)? Write a note on Gene therapy and its applications. (4+(3+3))
- Describe auto-immune disorders. What is the role of Immune system in organ transplantation? (6+4)
- a) Chaperons. (3)
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b) HSPs (Heat Shock Proteins). (3)
c) Protein Targeting. (4)
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
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