Download DNB 2016 Dec PHARMACOLOGY PAPER 1 Question Paper

Download Diplomate of National Board (DNB) 2016 Dec PHARMACOLOGY PAPER 1 Previous Question Paper

FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016
POSSESSION / USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
PHARMACOLOGY

PAPER ? I
PHARM/D/16/34/I
Time : 3 hours
Max. Marks : 100

Important instructions:

? Attempt all questions in order.
? Each question carries 10 marks.
? Read the question carefully and answer to the point neatly and legibly.
? Do not leave any blank pages between two answers.
? Indicate the question number correctly for the answer in the margin space.
? Answer all the parts of a single question together.
? Start the answer to a question on a fresh page or leave adequate space between two answers.
? Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. a) Define bioavailability and its clinical relevance.
b) Compare and contrast between bioequivalence and
therapeutic equivalence.

5+5
2. a) What is High Throughput Screening in drug development?
b) Experimental screening methods for potential anti-
arrhythmic activity of New Chemical Entity (NCE).

5+5
3. a) Compare and contrast between Therapeutic Index and
Therapeutic Window.
b) Factors influencing first pass metabolism of drugs and
therapeutic implication of this phenomenon.

5+(2+3)
4. a) Which are the sampling errors in drug screening
program?
b) What is the impact of sampling errors?
c) Enumerate the ways of reducing these errors.

2+3+5
5. a) Principle of spectrometry technique.
b) Its utility in clinical practice with suitable examples.

5+5
6. a) Define pA2 value.
b) Method of determination of pA2 value.
c) Applications of pA2 determination.

2+4+4
7. a) Targeted drug delivery.
b) Its utility in clinical practice.

5+5
8. a) Define chronopharmacology.
b) Aims of chronopharmacology.
c) Utility of chronopharmacology in clinical practice.

2+3+5
9. a) Define Good Clinical Practice (GCP) in drug development.
b) What are the principles of GCP?
c) Enumerate advantages of GCP.

2+4+4
10. a) ABC transporters.
b) Clinical relevance of these transporters.
5+5
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