Download DNB 2016 Dec IMMUNO HEMATOLOGY AND TRANSFUSION MEDICINE PAPER 1 Question Paper

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016

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Time : 3 hours
Max. Marks :100

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Important instructions:

• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.

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• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

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1. a) Prothrombin time — Clinical utilities. 4+6
   b) Explain International Normalized Ratio.
2. a) Coulter principle. 3+3+4
   b) Optical platelet count.
   c) Immature platelet fraction.

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3. a) Graft versus host disease (GvHD). 3+7
   b) Differentiate Transfusion from Transplant related GvHD including management and prevention.
4. a) Define stem cells. 2+3+5
   b) Hierarchy of Stem cells and iPS (induced Pluripotent Stem cell).
   c) Haematopoiesis from a pluripotent stem cell.

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5. a) ADAMTS 13. 4+6
   b) Thrombotic thrombocytopenic purpura.
6. a) Structure of Globin chain genes. 5+5
   b) Haemoglobin synthesis.
7. Bleeding assessment tools. 10

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8. a) Chromatography and Haemoglobin. 5+5
   b) Hb Variant analysis.
9. a) Vitamin B12 metabolism. 5+5
   b) Pernicious anemia.
10. a) ABO blood group system. 5+5
    

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    b) Molecular basis of A2 sub-group.