Download VNSGU MBBS 2022 January 1st Year Biochemistry Paper II Question Paper

ND-2006000101030002 Seat No.

First Year M. B. B. S. Examination

December - 2021

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Biochemistry: Paper - II

(New CBME Pattern)

Time: Hours] [Total Marks: 80

Instructions: (1)

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Fill up strictly the details of signs on your answer book.

Name of the Examination: First Year M. B. B. S.

Name of the Subject: Biochemistry: Paper - II

Subject Code No.: 2006000101030002

Section No. (1,2,.....): Nil

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Seat No.:

Student's Signature

1. Use blue/black ball point pen only.
2. The numbers to the right indicate full marks.
3. Draw diagrams wherever necessary

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Section B: (40 Marks)

2: Long Answer Questions (ANY TWO) (2 x 10 = 20)

1. Describe mutations. Explain various types of DNA repair processes with suitable diagram (4+6=10).
2. How phenylalanine is converted to tyrosine? Describe biologically important substances synthesized from tyrosine. Describe phenylketonuria in detail (2+5+3=10)
3. Describe coenzymes and isoenzymes. Write diagnostic and therapeutic applications of enzymes (2+2+4+2=10).

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3: Write Brief Answer / Justifications/Biochemical basis (ANY TEN) (10 x 2 = 20).

1. Restriction endonuclease.
2. Nutritional classification of amino acids.
3. Vitamin D is a pro-hormone, explain.
4. Telomerase is essential for dividing cells.

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5. IUB classification of enzymes with one example each.
6. Lead poisoning causes anemia.
7. Ammonia is toxic to brain.
8. Phenylalanine has sparing action on tyrosine
9. Glycine is a neurotransmitter

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10. Inhibitors of protein synthesis and their action.
11. Brown adipose tissue keeps body warm.

Section C: (40 Marks)

4: Short answer questions (ANY FOUR) (4 x 5=20)

1. Describe the polymerase chain reaction with its applications.

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2. Describe salvage pathway of purine nucleotide synthesis with associated disorders.
3. What is the clinical significance of 2, 3 -BPG? Add a note on effect of 2, 3-BPG on oxygen dissociation curve.
4. Metabolism and biochemical functions of vitamin D.
5. Biologically important peptides.

5: Clinical Cases (ALL COMPULSORY) (2 x 10 = 20)

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Case 1:

A newborn baby was brought with yellowish discoloration of skin and conjunctiva 5 days after birth. Serum unconjugated bilirubin was high. Treatment with phototherapy and oral phenobarbitone was started.

1. What is the diagnosis and cause of the above condition?
2. What is basis of phototherapy in treatment of this disorder?
3. What is basis of phenobarbitone in treatment of this disorder?

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4. What are serious consequences, if treatment is delayed in this patient?
5. Write Normal range of serum total, conjugated and unconjugated bilirubin?

Case 2:

43-year-old male working in a shipping company visited Dental OPD with complain of bleeding gums and hemorrhagic patches on the skin. He was taking frozen food throughout his sailing time. The dentist diagnosed him as a case of scurvy.

1. Write any four sources of vitamin C.

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2. Name the enzymes requires vitamin C as co-factor.
3. Vitamin C deficiency may be associated with iron deficiency, explain.
4. Human cannot synthesis vitamin C, justify.
5. RDA of vitamin-C.

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