Download VNSGU MBBS 2nd Year 2014 June Pharmacology Paper I Question Paper

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PR-4011

Second Year M. B. B. S. Examination

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June / July - 2014

Pharmacology : Paper - I

Time : 2 Hours] [Total Marks : 40

Instructions :

1. Fill up strictly the details of signs on your answer book.

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2. Answer must be brief, precise and to the point.
3. Always give suitable examples wherever needed.
4. Figures on the right indicate the marks alloted to the question.

1. Write as directed: (attempt all) 9
   1. What is maintenance dose? Mention important factor that determines the maintenance dose.
   2. Describe with clinical significance, the hepatic first pass effect.

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   3. Explain why atrophy of nasal mucosa is more likely in prolonged use of xylometazoline ?
   4. Explain with reasons whether salmeterol can be used for acute asthmatic attack.
   5. Explain with reasons whether warfarin can be used for initiation of treatment of deep vein thrombosis.
   6. Name two antimotility drugs and their two contraindications.
   7. What is peculiarity of esmolol ? Mention its clinical use.

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   8. Name two prostaglandin analogues used for induction of labour and two analogues for treatment of glaucoma.
   9. Explain with examples zero order kinetics.
2. Answer any three of the following: 9
   1. Name three drugs from different groups for treatment of chronic bronchial asthma. Briefly describe the mechanism of action and adverse effects of each.

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PR-4011] 1 [Contd...

2. 1. Describe the clinical uses of alpha blockers.
   2. Briefly describe the pharmacological basis of using each of the following.
      1. Adrenaline in anaphylactic shock
      2. Glucagon for betablocker poisoning

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   3. Write a brief note on each of the following
      1. Cholestyramine
      2. Tenecteplase
      3. Lepirudin

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3. Answer any three of the following: 12
   1. Write a note on each of the following:
      1. Bisacodyl
      2. Dextromethorphan
      3. Protamine sulphate
      4. Adenosine

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   2. Name four anti hypertensives that act by different mechanisms. Describe mechanism of action and adverse effect of each.
   3. Describe clinical uses of calcium channel blockers. Comment on their use in combination with Beta blockers.
   4. Name four antiemetic from different groups. Describe the mechanism, adverse effects and prefered use(s) of each.
4. Answer any two of the following: 10
   1. Explain how 5-HT is synthesized in body. Describe briefly the mechanism of action and clinical uses of various agents that act through 5-HT receptors.

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   2. Describe briefly the clinical uses and adverse effects of angiotensin converting enzyme inhibitors.
   3. Describe with suitable example(s) the pharmakinetics and pharmacodynamic interaction.

PR-4011] 2 200

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