Download VNSGU MBBS 2nd Year 2015 December Pharmacology Paper I Question Paper

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M-4011

Second Year M. B. B. S. Examination

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December 2015

Pharmacology : Paper - I

Time: 2 Hours] [Total Marks: 40

Instructions:

1. Fill up strictly the details of signs on your answer book.

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2. Answers must be brief, precise and to the point.
3. Always give suitable examples and draw figures where necessary.

1. Answer very briefly: 9
   1. Write down two examples of orphan drugs.
   2. What is 'desensitization' of receptor? Give two clinical examples.
   3. What will be the effect on BP if large dose of acetylcholine is given after the administration of atropine? Give the reason for your answer.

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   4. Name four antihypertensives of choice that can be prescribed to a female during pregnancy.
   5. What is teratogenicity? Name two teratogenic agents.
   6. Which are the types of aerosols? Give at least one example of each.
   7. What is INR? Write down recommended INR for any one indication.
   8. Why loperamide is not given in children below five years of age?

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   9. Name two diuretics used in the treatment of poisoning.
2. Answer any three: 9
   1. Enumerate different types of drug antagonism. Describe in detail receptor antagonism giving suitable examples and figures.
   2. Describe the mechanism of action of CCBs as antihypertensives. Write suitable indications for which they are prescribed and conditions for which they are avoided.
   3. Enlist the advantages of second generation Hantihistaminics. Describe the therapeutic uses of Hantihistaminics giving pharmacological basis.

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   4. Write a note on kinetics of elimination.
3. Answer any four: 12
   1. Classify drugs used in cough. Describe in short the non-opioids used in cough.
   2. Write a short note on a + ß blockers
   3. Enumerate LMWH. Describe therapeutics uses and adverse effects of heparin.

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   4. What is therapeutic drug monitoring (TDM)? Explain the situations with examples in which it is useful and is of no value.
   5. Explain briefly about rational drug combinations used for chronic prophylaxis of angina.
4. Answer any two: 10
   1. Enumerate various atropine substitutes. Write in detail about their therapeutic uses giving pharmacological basis.
   2. Classify antiemetic drugs. Describe mechanism of action, uses and adverse effects of any one commonly used class of

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   3. Describe in detail different types of drug interactions giving suitable examples.

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