Download VNSGU MBBS 2nd Year 2016 July Pharmacology Paper I Question Paper

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Second Year M. B. B. S. Examination

June/July - 2016

Pharmacology: Paper - I

Time: 2 Hours]

[Total Marks: 40

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Instructions:

(1)

(2) Answers must be brief, precise and to the point.

(3) Always give suitable examples and draw figures where necessary.

1. Answer very briefly: 9
   1. Mention the mode of administration of atropine in organophosphorus poisoning.

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   2. Mention the exact time of omeprazole administration. Give the reason for the same.
   3. Why oral iron therapy is required to be given for a long time in a patient of iron deficiency anemia?
   4. Mention one limitation of a drug with long half-life and type of dose which can overcome this limitation.
   5. What are drug compendia? Give two examples of official compendia.
   6. Enlist two advantages of LMWH administration over HMWH.

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   7. Give two reasons of importance of Zinc supplementation in pediatric diarrhoea.
   8. Name two antitussives used for productive cough.
   9. Write four uses of carbonic anhydrase inhibitors except diuretic use.

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2. Answer any three : 9
   1. Write a short note on apparent volume of distribution and its clinical significance.
   2. Describe the mechanism of action of metoclopramide. Enumerate their therapeutic uses and adverse effects.
   3. Write a short note on myasthenia gravis.
   4. Write in brief about therapeutic uses of atropine substitutes giving pharmacological basis.

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3. Answer any four: 12
   1. Enumerate therapeutic uses of ACE inhibitors. Explain the rationale for combining them with angiotensin receptor blockers.
   2. Which are the advantages of plotting log DRC? Write in detail about drug potency, drug efficacy and drug selectivity using the concept of DRC (Use figures maximum).
   3. Write a note on rational drug prescribing.
   4. Enumerate drugs used in bronchial asthma. Write a short note on leukotriene antagonists.
   5. Write down the adverse effects and uses of loop diuretics.

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4. Answer any two: 10
   1. Describe the various properties of ß adrenergic blocking drugs with clinical pros and cons. Describe their therapeutic uses giving proper pharmacological basis.
   2. Classify drugs used in congestive heart failure. Describe the mechanism of action, adverse effects and current clinical status of inotropic agents.
   3. Enlist various drugs from different categories for hypertension. Describe the general principles of antihypertensive drug therapy as per JNC 7th report.

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