Download VNSGU MBBS 2nd Year 2018 July Pharmacology Paper I Question Paper

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R-3714

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Second Year M. B. B. S. Examination

June / July - 2018

Pharmacology : Paper - I

[Time : 2 Hours] [Total Marks: 40

Instructions :

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(1) Fill up strictly the details of signs on your answer book.

(2) Answers must be brief, precise and to the point.

(3) Always give suitable examples and draw figures where necessary.

SECTION - I

1. Answer the following: 10
   1. Mention two advantages of LMW heparin over heparin.

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   2. Explain physiological antagonists giving suitable example.
   3. Physostigmine is preferred to neostigmine for treating atropine poisoning. Give reasons.
   4. Liquid paraffin is preferred in constipation during pregnancy. Give reasons.
   5. Name two teratogenic drugs.
   6. Enumerate two uses of alpha blockers.

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   7. Give two examples of centrally acting muscle relaxants.
   8. Give WHO definition of drug. Write two advantages of drugs prescribed by generic name.
   9. Define first pass metabolism. How first pass metabolism can be bypassed (avoided)?
   10. Name two uses of fibrinolytic therapy other than for myocardial infarction.

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2. Answer any four of the following: 8
   1. Discuss the mechanism of action & adverse effects of ACE inhibitors.
   2. Enumerate the contraindications to beta blockers.
   3. Write a short note on aliskiren.
   4. Write a note on rational use of medicine.

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   5. Describe "zero orde kinetics" and "first order kinetics" of drug elimination. With suitable examples describe their clinical importance.

SECTION - II

3. Answer any four of the following: 12
   1. Discuss the indications and adverse effects of parenteral iron therapy.
   2. Classify hypolipidemeic agents. Explain the mechanism of action, uses and adverse effects of HMG-CoA enzyme reductase inhibitor.

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   3. Discuss the therapeutic application of prostaglandins.
   4. Enumerate various drugs from different categories for treatment of angina. Describe how nitrates alter oxygen handling by the heart(Exclude molecular mechanism of drug).
   5. Discuss drug antagonism. Compare and contrast competitive and noncompetitive antagonists.

4. Answer any two of the following: 10
   1. Classify diuretics according to their site of action on nephron. Discuss the uses and adverse effects of furosemide.

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   2. Classify anti-cholinesterases. Describe the pharmacotherapy of organophosphorous poisoning.
   3. Enumerate the various drugs for bronchial asthma with their mechanism of action and side effects.

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