Download VNSGU MBBS 2nd Year 2014 January Pharmacology Paper I Question Paper

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P-4011

Second Year M. B. B. S. Examination

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February - 2014

Pharmacology: Paper - I

Time: [Hours]

[Total Marks: 40]

Instructions:

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Fill up strictly the details of signs on your answer book.

Name of the Examination:

SECOND YEAR M. B. B. S.

Name of the Subject:

PHARMACOLOGY: PAPER-1

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Subject Code No.: 4 0 1 1 Section No. (1,2....) Nil

Seat No.:

Student's Signature

(2) Answers must be brief, precise and to the point.

(3) Always give suitable examples wherever needed.

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(4) Figures on right indicate the marks allotted to question.

1. Answer the following: (Attempt all) 9

   1. Mention the clinical status and limitations of streptokinase.
   2. Explain the pharmacological basis of use of adrenaline in anaphylactic shock.
   3. Explain briefly the difference between allergic and idiosyncratic reaction.

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   4. Enumerate therapeutic uses of choline esters.
   5. Define: (i) Teratogenicity (ii) Phototoxicity.
   6. Explain briefly role of mucolytics in the treatment of cough.
   7. Explain briefly the limitations of nifedipine as an antihypertensive agent.
   8. Write briefly about xylometazoline.

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   9. Explain why beta blocker should not be combined with verapamil.

2. Answer any three of the following: 9

   1. Describe the drug therapy of relapse of peptic ulcer.
   2. Describe the clinical uses of phenylephrine. Mention the mode of administration for each use.

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   3. Describe the clinical uses of sodium nitroprusside. Mention the mode of administration and precaution required in its use.
   4. Explain mechanism of action and adverse effects of thiazide diuretics.

3. Answer any three of the following: 12

   1. Name four drugs for emesis that act by different mechanisms. Describe mechanism, uses and adverse effects of each.

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   2. Describe with preferred agent the clinical uses of prostaglandin analogues.
   3. Enumerate two first generation and two second generation antihistaminics. Describe merits and demerits of second generation antihistaminics.
   4. Write a brief note on each of the following:
      1. Salmeterol
      2. Iron sucrose
      3. Warfarin

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      4. Lepirudin.

4. Answer any two of the following: 10

   1. Enumerate five commonly used drugs from different groups for treatment of congestive cardiac failure. Justify use of each drug for the same.

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   2. Classify atropine substitutes and/or derivatives and describe their therapeutic uses.
   3. Describe with suitable examples the pharmacokinetic and pharmacodynamic interactions.

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