Download RUHS MBBS 2nd Year 2014 Jan-Feb Pharmacology Paper I Question Paper

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RUHS Second MBBS (Main) Examination Pharmacology Paper -I
Date: February 2014 Time: 3 hours Max Marks: 40

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Instructions: Attempt all questions. (Use separate answer sheet for each section)

SECTION A

1. Classify antiepileptic drugs. Discuss the mechanism of action, therapeutic uses and adverse effects of a sodium valproate. (A. 417, B. 131) (08)
2. Explain why: (4 x3 = 12)
   1. Pralidoxime is used for the treatment of organophosphorus and not carbamate poisoning(A. 111, B. 291)
   2. Tamsulosin is preferred over prazosin for the treatment of Benign Prostate Hypertrophy.(A. 142, 143, B. 977)

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   3. Antihistaminic are not effective for treatment of bronchial asthma.(A. 228, B. 360)
   4. Misoprostol is used for the treatment of NSAID induced peptic ulcer.(A. 654, B. 623)

SECTION B

3. Write short notes on; 3+3+4=10
   1. Transdermal therapeutic system(A. 6, B. 8)

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   2. Receptor regulation Plasma 1/2 and its clinical significance (A. 31, B. 21)
4. Give the suitable answer for the following; (1 x 10 = 10)
   1. What are the advantages of adding a vasoconstrictor to a local anaesthetic?(A. 363, B. 241)
   2. Write the mechanism of action of N-acetylcysteine for treating paracetamol poisoning(A. 207, B. 171)
   3. Why therapeutic drug monitoring is advised for patients on lithium therapy?(A. 447, B. 211) (A. 34, B. 24)

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   4. Morphine is contraindicated in patients of head injury(A. 474, B. 152)
   5. Bupivacaine is preferred epidural anesthetic for painless delivery and postoperative analgesia.
   6. What is rational drug use? Give one suitable example(A. 71)
   7. Name the sites where adrenergic receptors are present and the responses mediated by them.
   8. Name the commonly used nasal decongestants. Briefly write the mechanism of action and their side effects.(A. 136, B.268)

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   9. What is enzyme induction? Mention its clinical significance. (A. 26, B. 19)
   10. Why haloperidol is a preferred drug for the treatment of acute schizophrenia?

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