Download RTMNU B.Pharma 7th Semester 2017 Summer Biopharmaceutics and Pharmacokinetics Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 7th Semester 2017 Summer Biopharmaceutics and Pharmacokinetics Question Paper

NKT/KS/17/6581
B.Pharm. Seventh Semester (C.B.S.) Examination
BIOPHARMACEUTICS AND PHARMACOKINETICS
Paper?6
Time : Three Hours] [Maximum Marks : 80
NB. :? (1) Question No. 1 is compulsory.
(2) Attempt any FOUR questions from remaining.
(3) Draw neat labelled diagram wherever necessary.
(4) Discuss the reaction, mechanism wherever necessary.
(5) Use of electronic calculator, excluding programmable calculator is permitted.
1. Solve any FIVE questions :
(a)
(b)
(C)
(d)
(e)
(i)
(g)
2. (a)
(b)
What is ?rst pass effect ?
What is the relationship between apparent volume of distribution with clearance ?
Enumerate the objectives of bioavailability studies and explain the term absolute and relative
bioavailability.
What are the various causes of nonlinearity of drugs ?
What is IVIVC ?
Describe Hixon Crowell?s model for erodible matrix formulations.
What do you understand by tissue localization of drugs ? 5X4=20
Describe the various physiological baIriers affecting distribution of drug. 8
Discuss the signi?cance of protein bindings of drug. 7
3. Discuss in detail about phase I biotransformation of drug. 15
4. (a)
(b)
5. (a)
(13)
Describe the principal processes that determine the urinary excretion of a drug.
Describe the factors affecting renal clearance of drugs.
Describe the various methods of assessment of bioavailability.
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Describe the various transport mechanisms in absorption of drug.
6. Discuss the one compartment open model for IV Bolus and IV Infusion administration. 15
7. Write a short note (any THREE) :
(a)
(b)
(C)
(60
Theory of disillusion
Kinetics of protein drug binding
Gastric Emptying
Plasma Drug Concentration Pro?le. 3X5=15
NXO?12551