Download RTMNU B.Pharma 2nd Semester 2015 Winter Pharmaceutical Chemistry 2 (Organic) Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 2nd Semester 2015 Winter Pharmaceutical Chemistry 2 (Organic) Question Paper

NTK/KW/15/6976
B. Pharm. (Second Semester) (C.B.S.) Examination
PHARMACEUTICAL CHEMISTRY?II (2T2)
(Organic)
Paper?Z
Tirne?Three Hours] [Full Marks?8O
N.
B. :? (1) Question N0. 1 is compulsory.
(2) Solve any F OUR questions from the
remaining.
(3) Draw neat labeled diagram wherever
necessary.
1. Solve any F IVE of the following :
(a)
(b)
(C)
(d)
(e)
(f)
(5;)
Give sources of organic compounds with examples.
Write a short note on sequence rule.
Cis-trans isomerism.
Explain role of electronegativity in polarity of bond.
Defme and classify amines with examples.
Defme hybridization and classify them.
Di??rentiate between Con?guration and Conformation
20
MVM?46553 1 Contd.

2. (a)
(b)
What are racemic mixtures ? Explain various methods
of resolution of racemic mixture. 8
Explain Dumas method for determination of Nitrogen.
7
3. J ustify the following statements (any THREE) :
(a)
(b)
(C)
(d)
(b)
(b)
Acetic acid is acidic in nature.
Melting point of inorganic compound is higher than
organic compound.
Trans-isomers are more stable than cis-isomers.
Chair conformation of cyclohexane is more stable
than boat. 15
What is meant by conformers ? Discuss various
conformations existing in n-butane along with energy
pro?le diagram. 8
Explain Lassaighes test for detection of elements in
organic compounds. 7
Give brief account on hydrogen bonding and explain
its effect on aqueous solubility and bond lengths.
9
Assign suitable con?guration to following organic
compounds (any THREE) :
NH2
(1) H3C COOH
MVM?46553 2 Contd.
(ii)
(iii)
(1V)
6. (a)
(b)
(b)
CH CH
\KCZC/ 3
/ \
C1 Cl
Br C1
\CZC/
/ \
H CH3
CH20H
H H
CH2?OCH3 6
De?ne and classify alcohols with suitable examples.
How is di?erentiation between primary, secondary
and tertiary alcohols carried out ? 9
Draw structure offollowing compounds (any THREE) :
(i) 1, 3, 5-tribromo benzene
(ii) 2-cyclopenten-1-01
(iii) Ethyl, methyl amine
(iv) 3-chlor0 butanal. 6
What is mean by optical activity ? Explain conditions
for optical activity. What is meant by speci?c rotation
and how can one measure it ? 8
Explain various types of organic reactions with an
example from each class. 7
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