Download MBBS 2nd Year Pathology Paper I Important Questions

MBBS Second Year Pathology Paper-I Important Question
Bank

Essay Questions:
1. Define Oedema. Discuss the pathophysiology of oedema. Add a note on pulmonary oedema.

--- Content provided by FirstRanker.com ---

2. Define and classify Leukemias. Describe the blood and bone morrow findings in chronic myeloid
leukemia.
3. . Define inflammation. Describe the major events of acute inflammation with a note on
defective Leukocyte function.
4. Enumerate the various carcinogenic agents. Classify the chemical carcinogens and describe the

--- Content provided by FirstRanker.com ---

steps involved in chemical carcinogenesis.
5. Define Necrosis. Name the different types of necrosis. Discuss in detail with examples the
different types of necrosis. Differentiate between Necrosis and Apoptosis.
6. A 70 year old women admitted with worsening anemia and pathological fracture of the
Humerus had an ESR of 120mm in 1 hour. Her peripheral smear showed increased rouleaux

--- Content provided by FirstRanker.com ---

formation. Xray of skull showed multiple punched out osteolytic lesions. a. What is the most
probable diagnosis? Write briefly on the etiopathogenesis of this disease. b. Describe the Bone
Marrow Changes in this disease. c. Enumerate the common laboratory investigations for this
disease. d. Enlist the complications of this disease.
7. 40 yrs female c/o loss of weight, huge splenomegaly with peripheral blood white blood cell

--- Content provided by FirstRanker.com ---

count of more than 1 lakh cells/cc a. What is the probable diagnosis? b. What are the
characteristic peripheral smear findings? c. What is the course of the disease? d. What is the
chromosomal abnormality involved?
8. Define inflammation. Write in detail about the vascular and cellular changes in inflammation.
9. 60 yrs male presented with normocytic normochromic anaemia, pathological fracture femur and

--- Content provided by FirstRanker.com ---

proteinura. X ray skull revealed punched out lesions in the calvarium and peripheral smear
studied show rouleaux formation. a) What is your probable diagnosis. b) Discuss in detail the
molecular pathogenesis, morphology and clinical features of above said disorder.
10. Define shock. Discuss in detail the pathogenesis of septic shock. Describe the morphology of
kidneys and lungs affected by shock.

--- Content provided by FirstRanker.com ---

11. Chronic myeloid leukemia ? clinical features peripheral smear and bone marrow findings and
clinical outcome.
12. Write in detail about carcinogenesis physical, chemical and biological and also molecular basis of
Carcinogenesis.

---

13. Define and classify anaemia. Discuss etiopathogenesis, peripheral smear and bone marrow

--- Content provided by FirstRanker.com ---

picture in iron deficiency anaemia.
14. Define edema. Discuss the etiopathogenesis of various types of edema with examples.
15. Discuss in detail the molecular pathogenesis and morphology of Hodgkin lymphoma.
16. ) 23 yrs female presented with oral ulcers, malar rash photosentivity and non erosive arthritis
involving both knees. Laboratory investigations show persistent proteinuria and leucopenia.

--- Content provided by FirstRanker.com ---

What is your probable diagnosis. b) Discuss in detail the pathogenesis and morphology of kidney
affected by the above disorder.
17. 40 yr old male presented with h/o fever, vomiting and diarrhoea. Patient had temperature of
103 degrees F. Weak rapid pulse, hypotension, tachypnoea, cold, clammy, cyanotic skin. Blood
culture gram negative bacterial infection positive. (a) What is your diagnosis? (b) Explain the

--- Content provided by FirstRanker.com ---

pathogenesis and morphology.
18. Define thrombosis, write in detail about pathogenesis, causes, morphology and fate of
thrombus.
19. Define Thrombocytopenia? Classify causes of Thrombocytopenia? Discuss various tests in
evaluating bleeding disorders?

--- Content provided by FirstRanker.com ---

20. a) A 12 year boy weighing 70 kgs, doesn't play any outdoor games and is always in front of his
play station with lot of snacks besides him. What is he having? What are the methods to assess
it? b) What is the etiopathogenesis? Enumerate the complications?
21. Classify Hemolytic Anemias. Write in detail about the pathogenesis, blood picture and clinical
features of beta Thalassemia major.

--- Content provided by FirstRanker.com ---

22. Define Neoplasia. Write in detail about the molecular basis of cancers. Add a note on Oncogenes
and their mode of activation.
23. Define apoptosis. What are the causes of apoptosis? Write about the biochemical features and
mechanisms of apoptosis. Add a note on dysregulated apoptosis.
24. Describe the pathogenesis, morphology and clinical features of tuberculosis.

--- Content provided by FirstRanker.com ---

25. List the causes of megaloblastic anemia. Discuss about the pathogenesis, morphology and bone
marrow picture of megaloblastic anemia.
26. Define edema. Tabulate the pathophysiological categories of edema and write in detail about
each category with suitable examples and illustrations.
27. Define anaemia. Classify haemolytic anaemia. Write in detail about the pathogenesis, clinical

--- Content provided by FirstRanker.com ---

features and lab diagnosis of sickle cell anaemia.
28. Define Neoplasia. Discuss in detail the pathogenesis, pathophysiology of radiation oncogenesis.
29. Define inflammation. Describe the major events of acute inflammation with a note on its
outcome.
30. Define and classify leukaemia. Describe the blood and bone marrow findings in acute myeloid

--- Content provided by FirstRanker.com ---

leukaemia.
31. Define Inflammation. Enumerate the cellular events in acute inflammation. Discuss in detail the
mechanism of Chemotaxis and Phagocytosis.Enlist the common defects in Leukocyte functions.
32. Define and classify shock. Discuss in detail about septic shock.

---

--- Content provided by FirstRanker.com ---

Short Answer Questions:

1. Phagocytosis
2. Haematocrit
3. Sickle cell

--- Content provided by FirstRanker.com ---

4. Tumour suppressor genes
5. Anaphylactic reaction
6. Down's syndrome
7. Metaplasia
8. Kwashiorkar

--- Content provided by FirstRanker.com ---

9. Mycetoma
10. Eosinophilia
11. Name four causes of fatty liver
12. State four differences between dry and wet gangrenes
13. Define atrophy Give two examples to physiological atrophy

--- Content provided by FirstRanker.com ---

14. Describe four staining character of amyloid
15. Microscopic appearance of lepromatous leprosy
16. Name two opportunistic infections and two neoplasms seen in AIDS
17. Name two human oncogenic viruses and tumours caused by them
18. Blood components prepared in a blood bank

--- Content provided by FirstRanker.com ---

19. What is a Reticulocyte? Mention two causes of reticulocytosis
20. What is cross matching?
21. Free Radical Injury
22. Septic Shock
23. Rickets

--- Content provided by FirstRanker.com ---

24. Tertiary Syphilis
25. Proteins in urine
26. Cardiac edema
27. Klinefelter syndrome
28. Type I hypersensitivity reaction

--- Content provided by FirstRanker.com ---

29. Factors affecting wound healing
30. Apoptosis
31. Sago Spleen
32. Paraneoplastic syndromes

---

33. ESR

--- Content provided by FirstRanker.com ---

34. Coomb's Test
35. Reed Sternberg Cell
36. Hemophilia
37. Metaplasia
38. CVC liver

--- Content provided by FirstRanker.com ---

39. Blood picture in megaloblastic Anemia
40. CSF in tuberculous meningitis
41. Role of Arachidonic Metabolites in inflammation
42. Pathogenesis of Septic Shock
43. Tumour Metastasis

--- Content provided by FirstRanker.com ---

44. Mitochondrial Inheritance
45. Etiopathogenesis of Cystic Fibrosis
46. Anemia of Chronic Disease
47. FAB classification of Acute Leukemia
48. Idiopathic Thrombocytopenic purpura

--- Content provided by FirstRanker.com ---

49. Transfusion Reaction
50. Hematocrit
51. Give four examples for pathological calcification
52. Give four examples for Metaplasia
53. Mention two differences between exudates and transudate

--- Content provided by FirstRanker.com ---

54. Mention two renal changes in SLE
55. Give two examples for trace elements and their deficiency states
56. Give four causes for iron deficiency anaemia
57. Mention two important marrow changes in B deficiency
58. Two characteristic difference between Myeloblasts and Lymphoblasts

--- Content provided by FirstRanker.com ---

59. Mention two pathognomonic features of Hairy cell leukemia
60. Mention four applications of reticulocyte count
61. Classify pigments and write about Lipofuschin
62. Write about outcomes of acute inflammation
63. Growth factors

--- Content provided by FirstRanker.com ---

64. Hybridisation techniques to detect genomic alterations
65. Antibody mediated hypersensitivity
66. Molecular basis of cancer
67. Immunology of Leprosy
68. Primary myelofibrosis

--- Content provided by FirstRanker.com ---

69. Hemophilia A
70. Peripheral smear and Bone marrow findings in Multiple Myeloma

---

71. Define metaplasia and give two examples
72. Antiphospholipid antibody syndrome
73. Mention four X linked recessive disorders

--- Content provided by FirstRanker.com ---

74. Mention four special stains for Amyloid
75. Lead and blood and marrow changes
76. Four infections associated with AIDS
77. Hamartoma
78. Prions

--- Content provided by FirstRanker.com ---

79. Four Systemic effects of inflammation
80. Hyper IGM syndrome
81. Turner syndrome
82. Immune complex mediated hypersensitivity
83. Differentiation and anaplasia

--- Content provided by FirstRanker.com ---

84. Viral haemorrhagic fevers
85. Morphology of leprosy
86. Morphology of primary myelo fibrosis
87. Pathogenesis of sickle cell disease
88. Chronic immune thrombocytopaenic purpura

--- Content provided by FirstRanker.com ---

89. Free radicals
90. Defects in leucocyte function
91. Fat necrosis
92. Heart failure cells
93. Lines of zahn

--- Content provided by FirstRanker.com ---

94. Warburg effect
95. Mott cells
96. tumors associated with AIDS
97. Cross matching
98. Anticoagulants

--- Content provided by FirstRanker.com ---

99. PSEDO PELGER HUET ANOMALY
100.
Black water fever
101.
Air embolism

--- Content provided by FirstRanker.com ---

102.
Kline felters syndrome
103.
Arthus reaction
104.

--- Content provided by FirstRanker.com ---

Morphology of Primary Tuberculosis
105.
Fracture healing
106.
Sickle cell disease

--- Content provided by FirstRanker.com ---

107.
Poycythemia vera
108.
Leukemoid reaction

---

109.

--- Content provided by FirstRanker.com ---

Christmas disease
110.
Fanconi's Anemia
111.
Warthin finkeldey giant cells

--- Content provided by FirstRanker.com ---

112.
Factors downregulation apoptosis
113.
Gamma ? Gandy bodies
114.

--- Content provided by FirstRanker.com ---

Virchow's traid
115.
Bernard ? soulier syndrome
116.
Sago spleen

--- Content provided by FirstRanker.com ---

117.
Two special stain for Amyloid
118.
Howell ? Jolly bodies
119.

--- Content provided by FirstRanker.com ---

Tear drop cell
120.
MCV
121.
Oncogenic viruses

--- Content provided by FirstRanker.com ---

122.
Anaphylactic reaction
123.
Bence jones proteins
124.

--- Content provided by FirstRanker.com ---

Pathologic Calcification
125.
Vitamin A Deficiency
126.
Neonatal respiratory distress syndrome

--- Content provided by FirstRanker.com ---

127.
Von Willebrand's Disease
128.
Granulomatous inflammation
129.

--- Content provided by FirstRanker.com ---

Familial hypercholesterolemia
130.
Embolism
131.
Types of necrosis

--- Content provided by FirstRanker.com ---

132.
Factors influencing wound healing
133.
Fate of thrombus
134.

--- Content provided by FirstRanker.com ---

Clinical features of Trisomy
135.
Oncofetal antigens
136.
Reticulocyte

--- Content provided by FirstRanker.com ---

137.
Philadelphia chromosome
138.
Reed-Sternberg cell
139.

--- Content provided by FirstRanker.com ---

Tertiary Syphilis
140.
Agranulocytosis
141.
Caseous necrosis

--- Content provided by FirstRanker.com ---

142.
Pathology of Fracture healing
143.
Morphology of Thrombi
144.

--- Content provided by FirstRanker.com ---

Familial hypercholesterolemia
145.
Oncogenic Epstein ? Barr virus
146.
Pathogenesis of Amyloidosis

--- Content provided by FirstRanker.com ---

---

147.
Aetiology and morphology of bone marrow in Aplastic anaemia
148.
Morphology of multiple myeloma
149.

--- Content provided by FirstRanker.com ---

Molecular pathogenesis of Acute myeloid leukaemia
150.
Pathogenesis of disseminated intra vascular coagulation
151.
Define metaplasia & give examples

--- Content provided by FirstRanker.com ---

152.
Tigered effect
153.
Define Granuloma
154.

--- Content provided by FirstRanker.com ---

Systemic factors that influence wound healing
155.
Warburg effect
156.
Role of Vitamin C in wound healing

--- Content provided by FirstRanker.com ---

157.
Prothrombin time
158.
Megalobast
159.

--- Content provided by FirstRanker.com ---

Rh factor
160.
Auer rods
161.
Definition and characteristics of types of necrosis

--- Content provided by FirstRanker.com ---

162.
Phagocytosis
163.
Paraneoplastic syndromes
164.

--- Content provided by FirstRanker.com ---

Gaucher's disease
165.
Hypersensitivity reaction II
166.
Morphological changes in apoptosis

--- Content provided by FirstRanker.com ---

167.
Vascular events in acute inflammation
168.
Chemokines
169.

--- Content provided by FirstRanker.com ---

Morphology of infarct
170.
Opportunistic infections in AIDS
171.
Write any two stem cell niches

--- Content provided by FirstRanker.com ---

172.
Heinz bodies
173.
Types of leprosy
174.

--- Content provided by FirstRanker.com ---

Mention the cause of thrombocytopenia
175.
Bart haemoglobin
176.
Types of wound healing

--- Content provided by FirstRanker.com ---

177.
Two inherited disorders of platelets
178.
Two oncogenic DNA virus
179.

--- Content provided by FirstRanker.com ---

Two tumor suppressor genes
180.
Two examples of acute phase proteins
181.
Define Virchow's triad?

--- Content provided by FirstRanker.com ---

182.
Outcomes of acute inflammation?
183.
Caissons disease
184.

--- Content provided by FirstRanker.com ---

Epstein barr virus

---

185.
Leucocyte alkaline phosphatase
186.
Hemophilia A

--- Content provided by FirstRanker.com ---

187.
Wilms Tumor
188.
Amniotic fluid embolism
189.

--- Content provided by FirstRanker.com ---

Russell bodies
190.
Mention two sites of biopsy for amyloidosis?
191.
Autosomal recessive hematopoietic disorder

--- Content provided by FirstRanker.com ---

192.
Special stain to diagnose Gaucher's disease
193.
Fluorescent in situ hybridization
194.

--- Content provided by FirstRanker.com ---

Name two trisomy syndromes
195.
Neurofibromatosis gene
196.
Name two familial cancers?

--- Content provided by FirstRanker.com ---

197.
Stages of shock
198.
Mention two sites of oncocytomas
199.

--- Content provided by FirstRanker.com ---

Growth factors
200.
Transplant rejection
201.
Cystic fibrosis

--- Content provided by FirstRanker.com ---

202.
Hodgkin Lymphoma
203.
Dystrophic calcification
204.

--- Content provided by FirstRanker.com ---

Gaucher's cell
205.
Arthus reaction
206.
Chloroma

--- Content provided by FirstRanker.com ---

207.
Vitamin C deficiency
208.
Pathogenesis of shock
209.

--- Content provided by FirstRanker.com ---

Amyloidosis
210.
Megaloblastic Anemia
211.
Myelofibrosis

--- Content provided by FirstRanker.com ---

212.
Acute phase reactants
213.
Le cell
214.

--- Content provided by FirstRanker.com ---

Chronic granulomatous disease
215.
Langerhans cell histiocytosis
216.
Name four Monoclonal Gammopathies

--- Content provided by FirstRanker.com ---

217.
Embolism
218.
Stem cells in tissue homeostasis
219.

--- Content provided by FirstRanker.com ---

Myelodysplastic syndrome
220.
Von willebrand disease
221.
Role of sirutins in cellular aging

--- Content provided by FirstRanker.com ---

222.
Wilson's disease

---

223.
Sea blue histiocytosis
224.

--- Content provided by FirstRanker.com ---

Agranulocytosis
225.
Lead poisoning
226.
Gangrene

--- Content provided by FirstRanker.com ---

227.
Blood picture of chronic myeloid leukemia
228.
Disseminated intravascular coagulation
229.

--- Content provided by FirstRanker.com ---

Down syndrome
230.
Name four cell derived mediators of inflammation
231.
Differences between benign and malignant tumor

--- Content provided by FirstRanker.com ---

232.
Reed Sternberg cell and its variants
233.
Define hyperemia and congestion
234.

--- Content provided by FirstRanker.com ---

Four opportunistic infections in HIV
235.
Morphological patterns of tissue necrosis
236.
Tumor markers

--- Content provided by FirstRanker.com ---

237.
Klinefelter syndrome
238.
Haemophilia
239.

--- Content provided by FirstRanker.com ---

Metaplasia
240.
Lipoxins
241.
Morphology of thrombi

--- Content provided by FirstRanker.com ---

242.
Conditions associated with protein energy malnutrition
243.
Russell bodies
244.

--- Content provided by FirstRanker.com ---

Write about dystrophic and metastatic calcification
245.
Type III hypersensitivity reaction
246.
Enumerate four risk factors for DIC

--- Content provided by FirstRanker.com ---

247.
Morphology of granuloma
248.
Name the stages of shock
249.

--- Content provided by FirstRanker.com ---

Name four virus implicated in carcinogenesis
250.
Reticulocyte
251.
Chemical carcinogenesis

--- Content provided by FirstRanker.com ---

252.
Different types of giant cells with morphology and examples
253.
Protein energy malnutrition
254.

--- Content provided by FirstRanker.com ---

Glycogen storage disorders
255.
Mechanism of autoimmunity
256.
Warthin Finkeldey giant cells

--- Content provided by FirstRanker.com ---

257.
Types of necrosis
258.
Mention two causes for pancytopenia
259.

--- Content provided by FirstRanker.com ---

Mott cell
260.
Mention four X- linked recessive disorders

---

261.
Enumerate four examples for metastatic calcification

--- Content provided by FirstRanker.com ---

262.
Type II hypersensitivity reaction
263.
Von villebrand disease
264.

--- Content provided by FirstRanker.com ---

Factors affecting wound healing
265.
Obesity
266.
Tumor markers

--- Content provided by FirstRanker.com ---

267.
Vitamin D deficiency
268.
Hematocrit in dengue fever
269.

--- Content provided by FirstRanker.com ---

Dysplasia
270.
Phagocytosis
271.
Heinz bodies

--- Content provided by FirstRanker.com ---

272.
Give two examples of autosomal recessive disorder
273.
Actinomycosis
274.

--- Content provided by FirstRanker.com ---

Type I hypersensitivity reaction
275.
Blood and bone marrow picture in multiple myeloma
276.
Anti-phospholipid syndrome

--- Content provided by FirstRanker.com ---

277.
Mechanism of apoptosis
278.
Lab diagnosis of neoplasm
279.

--- Content provided by FirstRanker.com ---

Fracture healing
280.
Sago spleen
281.
Microscopic appearance of lepromatous leprosy

--- Content provided by FirstRanker.com ---

282.
Mention any four childhood malignancies
283.
Enumerate four types of chromosomal rearrangements
284.

--- Content provided by FirstRanker.com ---

Virchow triad
285.
Reed Sternberg cell
286.
Complications of myocardial infarction

--- Content provided by FirstRanker.com ---

287.
Sideroblastic anemia
288.
Tumour metastasis
289.

--- Content provided by FirstRanker.com ---

Graft versus host disease
290.
Viral haemorrhagic fever
291.
Down's syndrome

--- Content provided by FirstRanker.com ---

292.
Morphology of infarction
293.
Chloroma
294.

--- Content provided by FirstRanker.com ---

Vitamin C deficiency
295.
Name four cell derived mediators of inflammation
296.
Define hyperplasia and give two examples

--- Content provided by FirstRanker.com ---

297.
Anticoagulants
298.
Types and causes for Pathologic Calcification

---

299.

--- Content provided by FirstRanker.com ---

Type I hypersensitivity reaction
300.
Pathogenesis of Septic Shock
301.
Chemical Carcinogenesis

--- Content provided by FirstRanker.com ---

302.
Laboratory Investigations done for diagnosis of Autoimmune Haemolytic
Anaemia
303.
Enumerate two common cytogenetic disorders involving Sex Chromosomes

--- Content provided by FirstRanker.com ---

304.
Enlist two common stains used to demonstrate fat in tissues
305.
Mention two causes for Basophilic Stippling
306.

--- Content provided by FirstRanker.com ---

Enumerate four common organs involved in Amyloidosis
307.
Enlist four important sequelae for Thrombosis
308.
What is Bombay Blood group?

--- Content provided by FirstRanker.com ---

309.
Classification of acute leukemia
310.
Vitamin D deficiency
311.

--- Content provided by FirstRanker.com ---

Pathogenesis of aquired immuno deficiency syndrome
312.
Asbestosis
313.
Coagulation disorders

--- Content provided by FirstRanker.com ---

314.
Burkitts lymphoma
315.
Transcription factors
316.

--- Content provided by FirstRanker.com ---

Hematopoietic cytokines
317.
Asteroid bodies
318.
Keloid

--- Content provided by FirstRanker.com ---

319.
Mutations in chronic myeloid leukemia
320.
Hematocrit in dengue fever
********************************

--- Content provided by FirstRanker.com ---

---