Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13307 PCI Advanced Organic Chemistry I Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2019 13307 PCI Advanced Organic Chemistry I Previous Question Paper

- coe - coe
Code No. 13307 / PCI
M. Pharmacy (Pharmaceutical Chemistry) I ? Semester (Suppl.) Examination,
August 2019
Subject : Advanced Organic Chemistry ? I
Time : 3 hrs Max. Marks : 75
Note : Answer any FIVE questions. All questions carry equal marks.
1 a) Discuss the method of formation, stability and important reactions of free radicals
and carbanions. 8
b) Write the mechanism and stereochemistry of E
and E
eliminations. 7
2 Write a method of preparation, mechanism and applications of following synthetic
reagents (any three)
a) Diazomethane b) Osmonium tetroxide
c) Triphenul phosphine d) Witting reagent
e) Aluminium isopropoxide 3 x 5 = 15
3 a) Discuss the important guidelines for disconnection of molecules.
b) What is FGI, FGA, synthon and synthetic reagent? Explain giving one example
for each.
c) Discuss c-x disconnections in alcohols and carbonyl compnds. 6+4+5
4 Write the mechanism and synthetic applications of (any three)
a) Doebner-Miller reaction b) Sandmeyer reaction
c) Shapiro and Suzuki reaction d) Mannich addition 3 x 5 = 15
5 a) Write a note on (any two)
i) Knorr pyrazole synthesis
ii) Combes Quinoline synthesis
ii) Traube purine synthesis 2 x 4 = 8
b) Explain the methods for protection and deprotection of
i) Carbonyl grp ii) Amino grp 7
6 Mention the heterocyclic nucleus present and also the steps involved in the
synthesis of following drugs (any three)
i) Micronazole ii) Antipyrin
iii) Chlorpromazine iv) Quinacrine
iv) Triamterene 5 x 5 = 15
7 a) Discuss any two rearrangement reactions.
b) Explain mechanism in SN
reaction and also mention its stereochemistry.
c) What is Saytzeff?s rule? Explain with example? 6+5+4
8 Write a note on (any three)
a) Vilsmeyer-Hack reaction b) Wilkinson reagent
c) Sharpless asymmetric epoxidation d) BOP reagent 3 x 5 = 15
****** - FirstRanker's Choice

This post was last modified on 19 July 2020