Download OU M.Pharma Pharmacology 2nd Sem 2019 13329 PCI Principles Of Drug Discovery Question Paper

Download OU (Osmania University) M.Pharma-Pharmacology (Master of Pharmacy) 2nd Semester 2019 13329 PCI Principles Of Drug Discovery Previous Question Paper

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Code No. 13329 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) II ? Semester (PCI) (Main) Examination,
August 2019
Subject: Principles of Drug Discovery
Time: 3 Hrs Max.Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 a) Write a note on target identification and validation. 7
b) Describe abt role of transgenic animals in target validation. 8
2 a) Write a note on solid phase synthesis. 8
b) Explain in brief abt cell based high thrghput screening. 7
3 a) Write a note on traditional drug design. 5
b) Explain in detail abt virtual screening techniques. 10
4 a) Write a note on docking based screening. 7
b) Describe in brief abt h ansch analysis and free Wilson analysis. 8
5 a) Write the advantages of prodrug design. 6
b) Describe the practical consideration of prodrug design. 9
6 a) Explain in brief abt role of protein micro array in drug discovery. 6
b) Describe in detail abt types of protein structure. 9
7 a) Write a note on types of fluorescence screens in HTS. 8
b) Describe the concept of rational drug design. 7
8 a) Write a note on de-novo drug design. 7
b) Describe in brief abt 3D -QSAR. 8
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