Download University of Jaffna MBBS 2012 December Pharmacology Paper II Question Paper

1. Explain the pharmacokinetic basis for

   1. unexpected pregnancy in women on combined oral contraceptive pills following the use of broad spectrum antibiotics. (40 Marks)
   2. using probenacid in the treatment of chronic gout. (30 Marks)
   3. reduced efficacy of clopidogrel when taken with omeprazole. (30 Marks)

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2. 1. Classify the drugs used in the treatment of bronchial asthma. (20 Marks)
   2. Describe the mechanism of action of each group of drugs mentioned in 2.1. (40 Marks)
   3. Mention the different preparations available for each drug used in the treatment of bronchial asthma. (40 Marks)

3. Write an account on

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   1. therapeutic applications of carbamazepine. (30 Marks)
   2. adverse effects of methotrexate. (30 Marks)
   3. drug interactions of warfarin. (40 Marks)

4. Twenty year old girl with diabetes was admitted to the emergency unit in confused state. On examination respiratory rate was 35/ minute and she was dehydrated. Mother said that her daughter had stopped taking the medicine for diabetes for some time. The patient was treated for diabetic ketoacidosis.

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   1. List the therapeutic agents that you would use in the immediate management of this patient. (20 Marks)
   2. Explain the rationale for using the therapeutic agents mentioned in 2.1. for this patient. (40 Marks)
   3. Name the drug that you would prescribe for this patient on discharge. (10 Marks)
   4. Write the advice that you would give to this patient on discharge. (30 Marks)

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