UNIVERSITY OF JAFFNA, SRI LANKA
SECOND EXAMINATION FOR MEDICAL DEGREES PART II—FEBRUARY 2011
PATHOLOGY Paper II
Date: 22.02.2011. Time: 03 hours
ANSWER ALL THE TEN QUESTIONS
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Answer each QUESTION in separate answer book
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A patient is found to have a mid-diastolic murmur and is diagnosed as having mitral stenosis. He has a past history of Rheumatic Fever.
- List 2 other possible causes for mitral stenosis. (20 Marks)
- List 2 complications of mitral stenosis. (20 Marks)
- Describe the microscopic and macroscopic changes of the heart in Acute Rheumatic Fever. (50 Marks)
- List 2 other organs I tissues involved in Acute Rheumatic Fever. (10 Marks)
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A 68 year old known Diabetic patient presented with chronic cough, loss of weight and low grade fever. Chest X Ray revealed upper lobe shadows with cavitation. A clinical diagnosis of pulmonary Tuberculosis was made.
- List 2 investigations that would help to confirm the diagnosis. (20 Marks)
- Describe the pathological features of secondary (post primary) pulmonary Tuberculosis. (40 Marks)
- List 2 other pathological conditions of the lung that can cause granulomatous inflammation. (20 Marks)
- Enumerate the pathological sequelae of secondary pulmonary Tuberculosis. (20 Marks)
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40 year old female admitted with lump in the right breast of six months duration.
- Mention 5 physical signs to suggest it's clinically malignant lesion. (20 Marks)
- Explain the above physical signs on the basis of the pathology. (60 Marks)
- What is the significance of receptor studies in breast carcinoma? (20 Marks)
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- What laboratory investigations help to diagnose obstructive jaundice? (30 Marks)
- Brief out the pathophysiological changes that occur in obstructive jaundice. (35 Marks)
- Enumerate the causes of cirrhosis of the liver and mention the different macroscopic morphological appearances of the liver in each of them. (35 Marks)
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A 40 year old male presented with burning epigastric pain related to meals. An endoscopy performed on him revealed an ulcer at gastric antrum. The biopsy done on it revealed a chronic gastric ulcer with no evidence of malignancy.
- Define Peptic Ulcer. (10 Marks)
- Describe the macroscopic and microscopic appearances of peptic ulcer in stomach (gastric ulcer). (40 Marks)
- List 3 natural defenses in the stomach to protect it from gastric acidity. (15 Marks)
- Describe the pathological mechanism of Helicobacter pylori causing peptic ulcer (15 Marks)
- Mention 3 other aetiological agents for peptic ulcer disease (10 Marks)
- Enumerate the complications of peptic ulcer. (10 Marks)
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- Define Chronic Kidney Disease. (20 Marks)
- List the common 5 causes of Chronic Kidney Disease. (30 Marks)
- What are the consequences and complications of Chronic Kidney Disease? (50 Marks)
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A 40 year old female presented with excessive weight gain in spite of decreased appetite. Clinical diagnosis of Hypothyroidism was made.
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- List 2 investigations that would confirm the diagnosis. (10 Marks)
- Mention the changes that you would expect in the investigations you mentioned in 7.1 in primary and secondary hypothyroidism. (20 Marks)
- List 5 causes of hypothyroidism. (30 Marks)
- List the clinical manifestations of hypothyroidism in relation to:
- Cardiovascular system (20 Marks)
- Central nervous system (20 Marks)
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- List 5 important differences between benign and malignant tumours. (50 Marks)
- Describe the macroscopic and microscopic appearances of uterine leiomyoma. (40 Marks)
- Mention the name for malignant counterpart of leiomyoma. (10 Marks)
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A 68 year old man presented with lethargy and shortness of breath on exertion. He mentioned about passing dark colour stools on and off for 6 months. His preliminary investigations revealed;
Hb-5.001;
MCV- 60f1;
1\40-1-20pg:
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WBC-7000/mm³
Platelets-520,000/mm³
- What is the most likely cause for his anaemia? (10 Marks)
- List 2 other causes for microcytic anaemia. (20 Marks)
- List 3 biochemical investigations that you would do to confirm your diagnosis mentioned in 7.1 giving the expected findings (30 Marks)
- Describe the morphology of the red cells expected in his blood film. (30 Marks)
- What is the most likely cause for his thrombocytosis? (10 Marks)
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A 32 year old lady presented with loss of weight and fatigability of 6 months duration. On examination there was massive splenomegaly.
- List 3 conditions that can give rise to massive splenomegaly. (30 Marks)
- Her investigations showed:
Hb-logicil
\NBC-- 480,000/m м³
Platelets-900,000/mm3
Blood picture revealed marked leukocytosis with full spectrum of myeloid series with peaks in neutrophils and myelocytes. Eosinophilia and Basophilic were seen. Blasts were less than 2%.
What is the most likely diagnosis? (20 marks)
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- Mention one investigation from the peripheral blood that would Confirm the diagnosis. (20 Marks)
- Briefly explain her massive splenomegaly on the basis of pathology. (30 Marks)
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