Download University of Jaffna MBBS 2013 August Pharmacology Paper II Question Paper

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ANSWER ALL THE FOUR QUESTIONS.

Answer each Question in separate answer book.

1. Explain the pharmacological basis for using

   • 1.1. benzathinepenicillin in prophylaxis of rheumatic fever. (25 marks)

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   • 1.2. high dose atorvastatin in the immediate treatment of myocardial (25 marks) infarction.
   • 1.3. misoprostol to prevent NSAIDs-induced peptic ulcer disease. (25marks)
   • 1.4. sodium cromoglycate in the management of exercise induced asthma. (25marks)
2. • 2.1. Describe the pharmacokinetics of
     • 2.1.1. carbamazepine. (20 marks)

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     • 2.1.2. sodium valproate. (20 marks)
   • 2.2. Explain briefly the pharmacodynamics of
     • 2.2.1. carbamazepine. (10 marks)
     • 2.2.2. sodium valproate. (10 marks)

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   • 2.3. List two (02) clinically important adverse drug reactions of
     • 2.3.1. carbamazepine. (10 marks)
     • 2.3.2. sodium valproate. (10 marks)
   • 2.4. Discuss the term "risk versus benefit assessment" in the context of (20 marks) antiepileptic drug treatment.

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3. • 3.1. Classify insulins based on the duration of action with example. (30 marks)
   • 3.2. Describe the insulin regimens used in the treatment of type 1 diabetes mellitus. (45 marks)
   • 3.3. Write the advice that you would give to the patients when prescribing (25 marks) insulin.

4. Mrs. Ranjani was a 25 year old housewife. She underwent cardiac valve replacement 2 years ago and her cardiac functions were stable. She was on warfarin 10mg daily. Mrs. Ranjani wanted to have a baby.

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   • 4.1. Describe the anticoagulant therapy that you would plan for her during (30 marks) pregnancy.
   • 4.2. Explain the rationale for preferring the anticoagulant mentioned in 4.1. for this patient. (30 marks)
   • 4.3. Describe the precautions that have to be taken when using the drugs mentioned in 4.1. (40 marks)

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