UNIVERSITY OF JAFFNA, SRI LANKA
SECOND EXAMINATION FOR MEDICAL DEGREES-Part II (2nd)
December 2013
Pathology- Paper II
Date: 04.12.2013. Time: 3 hours
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Answer all the ten questions
Answer each question in separate answer book
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The patient presented with enlarged thyroid gland. Thyroidectorny was done and specimen was sent for histopathology. The report came as neoplasia of thyroid.
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- List 5different types of thyroid neoplasia. (20 Marks)
- Mention two (2) pathological changes (histological or cytological features) that will help in the diagnosis of each of the condition you have mentioned in 1.1.1. (30 Marks)
- Mention two (2) long term complications that may occur following thyroidectomy. (10 Marks)
- List two(2) laboratory investigation that would help to monitor each of the condition you mentioned in 1.1.3. ( 20Marks)
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- List five (5) biochemical changes that could be observed in a patient presented with tumour in the adrenal cortex. (20Marks)
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A 55 year old female presented to the surgical OPD with right hypochondrial pain. Ultrasonography reveals stones in the gallbladder.
- List the types of gall stones and mention three (3) risk factors for each type of gall stone you mentioned. ( 25Marks)
- Discuss the pathogenesis of gall stone. ( 40Marks)
- List five (5) complications of gall stone. (25 Marks)
- List two (2) biochemical changes that could be observed in common bile duct obstruction. (10 Marks)
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A 35 year old male patient admitted to surgical casualty ward following a road-traffic accident with extensive loss of skin and soft issue over the lower limbs.
- Mention the type of wound healing in this patient. (10 Marks)
- Briefly describe the steps involved in healing of this wound. (40)Marks)
- What is wound contraction? (IOMarks)
- List five (5) factors affecting the wound healing. (20Marks)
- List four (4) complications of wound healing in this patient. (20 Marks)
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Write short notes on
- chronic osteomyelitis. (25 Marks)
- Cervical Intraepithelial Neoplasia(CIN). ( 25Marks)
- complications of atherosclerotic plaque. (25 Marks)
- pathological calcification. (25 Marks)
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A 30-year-old man is admitted following fever. He had been prescribed a medication after which he noted passage of dark urine and yellow discoloration of his eyes. G6PD deficiency was suspected.
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- Describe the pathophysiology of yellow discoloration of his eyes. (20 Marks)
- Describe the pathophysiology of dark urine. (20Marks)
- List investigations that would confirm the diagnosis. (15Marks)
- List 3 abnormalities that you would see in his blood picture. (15Marks)
- What advice would you give on discharge. (20Marks)
- How is this disease inherited? ( I. °Marks)
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A 53 year old previously healthy teacher presented to the outpatient department with the history of headache and visual disturbance of two months duration. Full blood count report as follows:
Red blood cell count - 7.3x10 6 /pi
Haemoglobin 21.3g/cll.,
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Haematocrit 64%
White cell count 13x 103/p1
Neutrophil 75%,
Lymphocytes 10%,
Eosinophils 9%,
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Basophils 3%,
Monocytes 3%
Platelets 600%1031 pl
- Mention the abnormalities you can observe in his full blood count. (20Marks)
- What is the most likely diagnosis? (20 Marks)
- List two investigations from the peripheral blood that would be useful in confirming the diagnosis. (20Marks)
- Briefly describe the pathological changes you can observe in the bone marrow aspirate and trephine biopsy of a patient with the condition you mentioned in 6.2. (30Marks)
- Mention two complications of the condition you mentioned in 6.2. (10 Marks)
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A 34 year old male presented with blood and mucous diarrhea. The colonoscopy reveals ulcerated areas in the rectum. The histological diagnosis is that of Inflammatory bowel disease.
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- List the macroscopic and microscopic features that help to differentiate ulcerative colitis from Crohns disease. (50 Marks)
- Name three other conditions that can lead ulceration of the gastrointestinal tract. (30 Marks)
- List 2 complications of Inflammatory bowel disease. (20Marks)
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- Compare and contrast the vegetations seen in Rheumatic fever and Infective endocarditis. ( 40Marks)
- Describe the other macroscopic and microscopic features of the heart in Acute Rheumatic fever (other than vegetations). (30 Marks)
- What is the commonest valve affected in Rheumatic fever? (10Marks)
- List 2 other organs than are involved in Rheumatic fever. (20Marks)
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A 45year old male presented with cough, chest pain fever, and copious amounts of foul-smelling purulent sputum. The chest radiograph showed a right upper lung 3cm nodule with air- fluid level
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- What is the most probable diagnosis? (5 Marks)
- List three (3) predisposing causes of the condition you mentioned in (9.1.1). (15 Marks)
- Briefly Describe the pathological features of the above condition (20 Marks)
- List five (5) complications of this condition (10 Marks)
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A 50 year old man, who was a chain smoker presented with progressive dyspnea and cough for 1 year duration. The chest radiograph showed hyper inflated lungs with reduced vascular markings
- What is the most probable diagnosis? (10 Marks)
- Discuss the pathogenesis of the above process. (20 Marks)
- Describe the pathological features of the above condition. ( 20 Marks)
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- List main five (5) causes leading to chronic glomerulonephritis. (25Marks)
- Describe the pathological features of chronic glomerulonephritis. ( 25Marks)
- Briefly describe the pathological features of diabetic nephropathy. ( 25Marks)
- Describe the pathological features of most common type of renal cell carcinoma (adenocarcinoma ) of the kidney. (25Marks)
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