UNIVERSITY OF JAFFNA, SRI LANKA
SECOND EXAMINATION FOR MEDICAL DEGREES PART II
FEBRUARY 2011
PHARMACOLOGY Paper II
Date: 23.02.2011 Time: 2 hours
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Answer all four questions
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Explain:
- the rationale for choosing different routes for drug administration taking bronchial asthma as example. (50 marks)
- the pharmacokinetic basis for
- kernicterus in neonates treated with sulphonamide. (25 marks)
- interaction between lithium and thiazide. (25 marks)
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Explain the pharmacological basis for using
- misoprostol in NSAID induced gastric ulcer. (25 marks)
- diazepam as anaesthetic premedication. (25 marks)
- iodine in the preparation for thyroidectomy. (25 marks)
- desferrioxamine in iron overload. (25 marks)
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- Name 3 different groups of drugs that act on rennin-angiotensin system. (15 marks)
- Briefly describe the mechanisms of actions of the drugs mentioned in 3.1. (45 marks)
- Name 3 indications for each of the drug group mentioned above. (20 marks)
- Mention 5 adverse effects of each of the above-mentioned drug groups. (20 marks)
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A 20year old boy was admitted to the emergency unit with history of ingestion of a pesticide. He complained of vomiting, abdominal pain, difficulty in breathing and weakness of limbs. On examination he was conscious but, restless, sweaty and the pupils were constricted. His heart rate was 48/ minute and auscultation revealed bilateral rhonchi and coarse crepitations. The diagnosis was made as organophosphate poisoning.
- Explain the pharmacological basis for the signs and symptoms in this patient. (60 marks)
- Describe the drug treatment of this patient. (20 marks)
- Explain the rationale for using the drugs mentioned in 4.2. (20 marks)
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