Download University of Jaffna MBBS 2014 August Pharmacology Paper II Question Paper

UNIVERSITY OF JAFFNA, SRI LANKA

SECOND EXAMINATION FOR MEDICAL DEGREES PART II (1ST) — August 2014

Pharmacology Paper II (old)

Date: 07.08.2014

Time: 02 hours

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ANSWER ALL THE FOUR QUESTIONS

1. 1. Define the term "adverse drug reaction". (10 marks)
   2. List three (03) potentially harmful effects of drugs (other than adverse drug reactions). (15 marks)
   3. List five (05) reasons for the need of post-marketing surveillance of drugs. (25 marks)
   4. Explain briefly why penicillin-induced anaphylactic shock is classified as Type B adverse reaction. (20 marks)

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   5. Explain briefly why safety of medicines is different in children compared to adults. (30 marks)
2. 1. Give two (02) example for
      1. direct acting cholinomimetics. (10 marks)
      2. indirect acting cholinomimetics. (10 marks)

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   2. List four (04) indications of cholinomimetics. (20 marks)
   3. Explain the clinical manifestations of organophosphate poisoning. (30 marks)
   4. Describe the drug treatment of organophosphate poisoning. (30 marks)
3. 1. Give three (03) reasons for considering methotrexate as a first-line disease modifying antirheumatoid drug. (15 marks)

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   2. List the adverse effects of methotrexate. (20 marks)
   3. What precautions would you take when prescribing methotrexate? (20 marks)
   4. List four (04) contraindications for methotrexate therapy. (20 marks)
   5. List the circumstances where corticosteroids are indicated in the treatment of rheumatoid arthritis. (25 marks)

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4. Write an account on

   1. ACE inhibitors (30 marks)
   2. Treatment of amoebiasis. (30 marks)
   3. Hormonal contraception. (40 marks)

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