UNIVERSITY OF JAFFNA, SRI LANKA
SECOND EXAMINATION FOR MEDICAL DEGREES PART II (First) October 2011
PHARMACOLOGY
Paper II
Date: 19.10.2011 Time: 02 hours
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ANSWER ALL THE FOUR QUESTIONS
Answer each Question in separate answer book
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Explain the pharmacokinetic basis for:
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- Having different dosage schedules for morphine oral short acting, morphine controlled released and morphine parenteral preparations. (45 Marks)
- Mention one indication for each of the above mentioned preparations of morphine. (15 Marks)
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- Changes in prescribing in liver diseases. (40 Marks)
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- Classify oral hypoglycaemic agents. (25 marks)
- Mention 2 common adverse effect of each drug group mentioned in ai (30 marks)
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What is the oral hypoglycaemic agent of choice for patients with following co morbid conditions? Give reasons for your choice.
- Type 2 diabetes mellitus and obesity. (15 Marks)
- Type 2 diabetes mellitus and chronic renal disease. (15 Marks)
- Type 2 diabetes mellitus and heart failure. (15 Marks)
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Write an account on:
- Oral iron therapy. (30 marks)
- Combined oral contraceptive pill. (30 marks)
- Role of ACE inhibitors in cardiovascular disorders. (40 marks)
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A 30 year old pregnant woman was admitted to the medical ward with the history of cough, fever, loss of appetite and loss of weight of 4 weeks duration. Her sputum AFB was positive and diagnosed as post-primary pulmonary tuberculosis.
- Describe the drug treatment of this patient. (30 marks)
- What precautions would you take when treating this patient with the drugs mentioned in 4.1.? (20 marks)
- If this patient develops yellow discolouration of sclera and skin, how would you manage? (25 marks)
- If she has delivered a baby 2 days after the diagnosis of tuberculosis, how would you manage the baby? (25 marks)
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