Download MBBS 1st Year WBUHS Anatomy Important Questions

10 YEARS' QUESTION PAPERS FOR 1ST PROF. MBBS EXAM: ANATOMY

SUPERIOR EXTREMITY

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GROUP-A(12 MARKS)

1. Describe the intrinsic muscles of the hand. What is total claw hand ? [10+2][2014]
2. Name the nerve involved in the fracture of medial epicondyle of humerus. Describe the

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course and distribution of the nerve beyond the elbow. Mention sensory and motor
disabilities following the nerve injury. [1+6+5][2013]

3. Describe the anatomical features of the female breast in the adults. In case of breast

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carcinoma, how can you account for : A) Retraction and punching of skin? B)Peau `d
Orange or edema with pitting of the skin over the breast? C) Retraction of nipple?
[6+2+2+2]2007]

4. A case of breast tumor in an aged patient presents enlarged nodular swellings in the axilla.

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How and in what groups are they arranged in the axilla. Name their different efferent and
afferent pathways. Which walls of axilla should one avoid draining the pus and why?
[6+4+2][2006]

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5. Enumerate the ligaments of shoulder joint. How the stability of the joint is maintained?

Mention the nerve supply of the joint. Discuss the mechanism of elevation of arm above the
head. Which type of dislocation is common and why? [2+2+2+4+2][2016]

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6. Describe the brachial plexus under the following headings : roots, trunks, divisions, and

cords. What do you mean by Erb's point? Adda note on Klumpke's paralysis.[6+3+3][2015]

7. What are the palmar spaces? Describe the thenar muscles with their nerve supply and

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actions.[3+9][2017]

GROUP- B (7 MARKS)

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1. A man presents with neuromuscular disability following the fracture of the surgical neck of

the humerus. Give a brief account of the nerve affected for its close relation to that part of the
bone. From your anatomical knowledge , mention the motor and sensory defects that may
arise.[5+2][2010][2015]

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2. A factory worker presents with acute pain and swelling of the central part of his right hand

following infection of the webbed space b/w middle and ring fingers. Use your anatomical
knowledge to explain this complication. Write a brief note on the palmar space affected.

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[2+5][2009]

3. Following a street accident a young man develops fracture of the mid shaft of the humerus.

Discuss the distribution of this nerve related to that part of the bone while it passes through

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the arm. Add a note to its lesion as it passes through the spiral groove of the bone.[4+3][2008]

4. Describe the shoulder joint. Justify the statement , "Shoulder joint enjoys mobility at the

expense of stability".[7][2007]

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5. In which direction head of humerus commonly dislocates & can stretch and injure an

important nerve of upper limb?[4+2+1][2007]

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6. Injury of anatomical snuff box of wrist may injure the artery which forms the deep palmar

arch in hand. Describe its course; name its branches.[4+3][2006]
7. Define the long bone. Describe the different parts of young long bone. Describe the blood

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supply of long bone.[1+3+3] [2016]

GROUP ?C (3 MARKS)

1. Anatomical snuff box of hand.[2014]

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2. Cephalic vein.[2013]
3. Quadrangular and triangular space.[2012]
4. Clavipectoral fascia.[2010]
5. Carpal Tunnel Syndrome.[2009][2008]
6. Rotator Cuff.[2005]

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7. Erb-Duchenne paralysis.[2004]
8. Laws of ossification.[2015]

GROUP ? D (3 MARKS) EXPLAIN WHY

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1. Painful arch syndrome.[2014]
2. Clavicle is a modified long bone.[2013, '09, `06]
3. Injury to the radial nerve in the cubital fossa will not cause wrist drop.[2012]
4. Injury to the long thoracic nerve causes winging of the scapula.[2012]
5. Upper end of the humerus is an example of a compound epiphysis.[2010]

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6. A palpable nodule in the axilla of an elderly lady should be properly cared.[2009]
7. Metastasis of carcinoma from the inferomedial quadrant of breast may spread to the pelvic

cavity.[2006]

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8. In shoulder joint dislocation, the humerus generally dislocates inferiorly.[2005]
9. Fracture of the scaphoid of the wrist is often associated with avascular necrosis of the

proximal segment.[2004]

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10. Fracture of shaft of humerus causes wrist drop.[2017]
INFERIOR EXTREMITY

GROUP- A (12 MARKS)

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1. Name the bones forming the knee joint. Describe the locking and unlocking movements of

knee joint. [2+10][2014]

2. What are the muscles there after cutting the gluteus maximus? Name the nerves supplying

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these muscles. What are the actions of these muscles on hip joint? [3+4+5][2012]

3. Following an automobile injury a person lost the adductor movement of his leg. Describe the

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injured nerve under following headings: origin, branches and distribution.[3+4+5][2011]

GROUP- B(7 MARKS)

1. Describe the factors maintaining the longitudinal arches of the foot. What are the

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disadvantages of flat foot ? [5+2][2013]

2. A bus conductor is having prominent veins in the leg during standing position. What are the

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superficial veins present in the leg? What are the origin, termination, tributaries of the short
saphenous vein? What is varicosity of leg veins? [2+4+1][2011]

3. A factory worker presents with swollen painful inguinal lymph nodes following an uncared

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wound at the medial side of ankle. Explain the complication from your anatomical
knowledge. Write a brief note on inguinal lymph nodes.[2+5][2010]

4. A child suffers from bilateral congenital dislocation of hip joint. Mention the anatomical type

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of dislocation of the hip joint. What are the factors maintaining the stability of hip
joint?[2+5][2009]

5.

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An athlete while running experienced severe cramp in the right thigh and was diagnosed as

a case of pulled hamstrings. State the characteristics of hamstrings. Mention the origin,
insertion , nerve supply and actions of these group of muscles.[3+4][2008]

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6. In case of fracture dislocation around the knee joint, which artery is likely to be avulsed?

Name and describe the artery along with the arteries that supply the knee joint.[4+3][2007]

7. Which joints are involved in the movements of inversion and eversion? Name the invertors

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and evertors of foot. What is the axis of these movements? Name the nerve supplying these
muscles. Which segment of spinal cord controls the movements of the foot?
[1+2+1+2+1][2006]

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8. A mid-aged woman develops varicose leg veins. How superficial veins are connected to deep

veins? Briefly describe the anatomical factors preventing the varicosity of leg
veins.[3+4][2005]

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9. A footballer sustained sprain followed by difficulty in normal movements of his left knee

after he attempted to kick the ball through his right foot. He was diagnosed to have injury on
the semilunar cartilages of his left knee. Explain the anatomical basis of his injury. Give a
brief note on the semilunar cartilage of the knee joint. Which semilunar cartilage is

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susceptible to injury and why? [2+3+2][2004]
GROUP-C (3 MARKS) SHORT NOTES

1. Femoral sheath.[2013]
2. Deltoid ligament.[2011, `08]

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3. Popliteus muscle.[2010, `04]
4. Ischial spine.[2009]
5. Acetabular labrum.[2007]
6. Illio-femoral ligament.[2006]

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GROUP-D (3 MARKS) EXPLAIN WHY

1. Foot drop after the fracture of the neck of the fibula.[2011, `06]
2. Peroneus longus muscle has effects on both longitudinal and transverse arches of

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foot.[2010, `08]

3. Injury to the superior gluteal nerve shows the positive Trendelenberg's sign.[2009]
4. Medial meniscus is susceptible to injury more frequently than the lateral meniscus.[2005]
5. Femoral hernia is more common in females than in males.[2004]

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THORAX

GROUP- A(12 MARKS)

1. Describe the transverse pericardial sinus with its development. What is its clinical

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importance? [8+2+2][2014]

2. Give an account of pleura. Mention its nerve supply. What is the site of choice for insertion

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of needle to drain pleural fluid and why?[6+3+3][2013]

3. Name the arteries arising from the ascending aorta. Give the course & branches of the supply

of these arteries.[2+5+5][2007]

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4. What are the cardiac anomalies associated with Fallot's Tetralogy? Give a brief account of

the interventricular septum. Name & number the different broncho-pulmonary segments.
Mention its applied importance.[2+6+4][2005]

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5. An elderly man complains of frequent chest pain on exertion & is advised to have coronary

artery angiography. Give the usual pattern of coronary supply of heart. How interventricular
septum is developed and what are the possible errors there of? [6+4+2][2004]

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6. Pleura: types, nerve supply, reflections/recesses, applied importance.[2017]

GROUP- B (7 MARKS)

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1. Give the development of atrio-ventricular septum. A pin pricked to the tight sight of the

septum will reach to which pat of the heart? [5+2][2014]

2. Coronary artery supply of heart. What is coronary dominance? [6+1][2012]

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3. A young patient with repeated vomiting and reflux on examination was diagnosed with

diaphragmatic hernia. Explain the condition from your anatomical knowledge. Give the
origin, insertion and nerve supply of diaphragm. [2+5][[2011]

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4. A child with history of cough, fever & breathlessness and exertion along with cyanosis since

birth, was diagnosed as a cause of Fallot's Tetralogy. Explain the disorder embryologically.
Write a short note on development and blood supply of IV septum. [4+3][2008]

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5. A patient with history of cough, fever and breathlessness was diagnosed to be a case of

pleural effusion. Give a brief account of pleura with its recesses and nerve supply.[2010]

6. A mid-aged lady suffered from dysphagia due to oesophagus following an attempt to

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commit a suicide by consuming corrosive chemicals. Using your knowledge of anatomy for
normal constriction of oesophagus , mention the possible site of stricture. Describe the
important relations and clinical anatomy of oesophagus.[2+5][2005]

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7. Patient complaining of pain during respiration and breathlessness due to accumulation of

fluid in the plural sac. Name the different parts of pleura along with its nerve supply.
[4+3][2004]
GROUP-C (3 MARKS) SHORT NOTES

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1. Central tendon of diaphragm.[2015]
2. Bronchopulmonary segments of left lung.[2016][2004]
3. Ligamentum arteriosum.[2014]
4. Nerve supply of apical pleura.[2014]

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5. Inlet of thorax.[2013]
6. 1st intercostal nerve.[2012]
7. Oblique sinus.[2007]
8. Left coronary artery.[2010]
9. Respiratory epithelium.[2009]

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10. Constrictions of oesophagus.[2008][2007]
11. Costo-diaphragmatic recess of pleura.[2006]
12. Histology of oesophagus.[2006]
13. Fallot's Tetralogy.[2004]
14. Typical intercostal nerves.[2005]

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15. Broncho-pulmonary segments.[2016][2004]

GROUP-D (3 MARKS) EXPLAIN WHY

1. Central tendon of thoraco-abdominal diaphragm is bending with the basal part of fibrous

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pericardium.[2014]

2. Tracheo-oesophageal fistula.[2012]
3. Type of respiration in infant is abdominal, where as thoracic in adult females and and

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thoraco-abdominal in adult males.[2012, `09]

4. Segment 2 and 6 of lungs are sites of lung abscess.[2011]
5. Entry of foreign body is common to the right bronchus.[2011]

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6. Transposition of great vessels.[2011]
7. Intercostal nerves other than 3rd to 6th are atypical.[2010]
8. Right recurrent laryngeal nerve hooks around the right subclavian artery where as the left

one rounds the ligamentum arteriosum.[2008]

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9. Hyaline cartilage is present in the wall of trachea and bronchus.[2006]
10. Cervical rib.[2005]
GENERAL ANATOMY, EMBRYOLOGY AND GENETICS

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GROUP-B(7 MARKS)

1. Describe the development of placenta in short . What is placenta previa? [2+5][2014]
2. What is metaphysis of a growing bone. Give its importance.[2+5][2014]
3. Mention the main structural characteristics of a synovial joint. Classify synovial joint with

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example of each type. [3+4][2012]

GROUP-C (3 MARKS) SHORT NOTES

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1. Difference b/w transitional and stratified squamous epithelium.[2014]
2. Capacitation.[2014]
3. Placental barrier.[2013]
4. Non-disjunction.[2013]
5. Epiphyseal cartilage.[2012]

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6. Down's syndrome.[2011, `04]
7. Klinefelter's syndrome.[2011]
8. Plasma cell.[2010, `05]
9. Light microscope structure of lymph node.[2009]
10. Allelic gene.[2007]

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11. Notochord.[2007][2016]
12. Barr body.[2006]
13. Sarcomere.[2016]
14. Karyotyping.[2016]
15. Blastocyst.[2015]

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16. Turner's syndrome.[2015]
17. Laws of ossification.[2015]

GROUP-D(3 MARKS) EXPLAIN WHY

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1. Osteoclast.[2014]
2. Double Barr body in Klinefelter's syndrome.[2012, `11]
3. Monozygotic twins are identical while dizygotic twins are non-identical.[2012]
4. An elderly female(38 yrs) gave birth to a baby who is examined to have a rounded face,

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epicanthic folds and characteristic single palmar crease ( Simian Crease) on the palm.
Explain the genetic cause of the event.[2011]

5. Presence of Barr body in buccal smear of male patient.[2005]
6. Annular pancreas.[2016]

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NEURO-ANATOMY

GROUP-A(12 MARKS)

1. Give the arterial supply of the superolateral surface of the brain. What is macular sparing?

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[10+2][2014]

2. What is Argyll-Robertson's pupil? Mention the sites of lesion for this type of abnormality.

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With a suitable diagram, describe the features of the transverse section of the mid brain at
the level of superior colliculus. Describe the pathway for light reflex.[2+1+6+3][2006]

3. What is arterial circle of Willis? Describe the arterial supply of superolateral surface of

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cerebral hemisphere.[5+7[2016]]

4. Enumerate the white fibres in the brain. Describe the internal capsule under the following

heads: Parts with relations, fibres passing through different parts and blood supply. What

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is stroke?[2+3+4+2+1][2017]

GROUP-B (7 MARKS)

1. CT scan of the brain of a patient suffering from cerebro-vascular accident shows a

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lesion in the internal capsule of the brain. State why this part is called "Internal
Capsule". Mention the different fibres passing through the internal capsule. Add a
note on its blood supply. [1+3+3][2010]

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2. A 60 years old person suffers from cerebellar ataxia following vascular damage.

Mention the arterial supply and phylogenetic subdivision of cerebellum. What do you
mean by cerebellar ataxia? [2+3+2][2009]

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3. A patient with Argyll-Robertson's Pupil presents with persistence of accommodation

reflex but loss of light reflex. Briefly discuss the accommodation reflex pathway.
State how can you justify the specific neurological deficit in this case.[5+2][2008]

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4. Enumerate the ventricles of the brain. Describe the circulation of the CSF. Add a note

on the blood-brain-barrier.[1+4+2][2005]

5. An old man of 65 years gets an attack of UMN paralysis. What is the internal capsule

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of the brain? Mention the composition and blood supply of its parts.[5+2][2005]

6. Describe the walls and communications of 3rd ventricle. What is non-communicating

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type of hydrocephalous? [4+1+2][2016]

7. Describe the floor of the 4th ventricle with proper diagram.[7][2017]
8. What are the different parts of cerebellum? Mention their blood supply. What is

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cerebellar ataxia?[4+2+1][2015]
GROUP-C (3 MARKS) SHORT NOTES

1. Thalamic nuclei.[2011]
2. Boundaries and communications of 3rd ventricle of the brain.[2010]

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3. Motor neurons of spinal cord.[2009]
4. Blood-brain-barrier.[2008]
5. Tectum of midbrain.[2005]
6. Blood supply of spinal cord.[2017]

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GROUP-D( 3 MARKS) EXPLAIN WHY

1. Lesion in pretectal nucleus of midbrain causes Argyll-Robertson's pupil.[2009]
2. Visual defect due to occlusion of posterior cerebral artery does not affect macular

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vision.[2008]

3. Optic nerve is not a peripheral nerve.[2007]
4. Patient with pituitary tumor suffers from bitemporal hemianopia.[2016]
5. Increased intra-cranial pressure may cause medial squint.[2015]

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6. In anterior spinal artery syndrome there is bilateral loss of pain and temperature sensation

but conscious propioceptive sensations are lost.[2015]

7. Increased pressure of CSF in subarachnoid space is easily diagnosed by opthalmoscopic

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examination of the eyes. [2017]
ABDOMEN

GROUP ?A (12 MARKS)

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1. Give a brief note on ureter. Mention its microscopic structure & development. In which

clinical condition pain may extend from loin to groin involving ureter? [5+2+2+4][2013]

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2. A young married lady with the history of missed period, suddenly collapsed with sharp

lower abdominal pain & was diagnosed ruptured tubal pregnancy. What is the
commonest site of tubal pregnancy and its fate? Mention the parts of this tube, blood
supply, histological structure and development.[2+3+2+3+2][2012]

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3. A 50 years old man was brought to OPD with a complaint of swelling at the midline of

anterior abdominal wall over an operative scar. Swelling was diagnosed as incisional
hernia through the rectus sheath. A) Give its formation at different levels. B)What are the

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contents of the rectus sheath? C)Define the sheath. D) Why is median incision not
preferred over the anterior abdominal wall?[2+5+3+2][2011]

4. An old man suffering from carcinoma of prostate with metastasis in vertebra. From your

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anatomical knowledge explain this complication. Discuss briefly the capsules, lobes, and
relations of the prostate gland. Add a note on the interior of the organ.[2+6+4][2010]

5. Prevaginal examination of an elderly lady suffering from pelvic inflammatory disease

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reveals collection of fluid in the pouch of Douglas. Write a note on this pouch and
peritoneal as well as visceral relation of the uterus. Give a brief account of the supports to
this organ. [3+4+5][2010]

6. A child presents leakage of urine through umbilicus from urinary bladder. Using your

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anatomical knowledge explain the congenital anomaly with a note on development of
urinary bladder. Give a brief account of the features with relations , ligaments, and nerve
supply of the organ. [3+9][2009]

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7. A young lady was brought to the emergency with acute lower abdominal pain & features

of shock diagnosed as a case of ruptured ectopic gestation. Mention the usual site of
ectopic gestation. Discuss the gross anatomy , development and microscopic anatomy of
the organ involved.[2+10][2009]

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8. What are the parts of fallopian tube and where does fertilization usually occur? Give

blood supply, histological structure and development of the same.[2+3+4+3][2004]

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9. During routine investigation, USG of whole abdomen of an adult revealed horseshoe

shaped kidney. Explain the case with your embryological point of view. Discuss briefly
the development of kidney. Add a note on its clinical anatomy with congenital
anomalies.[2+5+5][2008]

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10. An anxious lady complains that the right scrotal sac of her new born male baby is empty.

The case is diagnosed as one of the cases of congenital anomalies of descending testes.
Discuss various anomalies of descent of testes. Explain how female gonad is different

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from male.[5+5+2][2008]

11. A hollow muscular pelvic organ when full and distended strip off peritoneum behind the

supra pubic part of the anterior abdominal wall. Give an account of anatomical parts ,

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surfaces and ligaments of the organ. Describe the interior features of the base of the organ.
How the organ does develop?[6+3+3][2006]
12. A fatty lady of 45 years with prolonged history of hyperacidity and dysphagia was

brought to hospital with acute pain in epigastrium and in right shoulder. She was finally

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diagnosed as a case of Cholelithiasis (gall stone). Using your anatomical knowledge can
you explain the pain in both epigastrium and right shoulder and the peripheral pain
pathway? Give a brief anatomy and clinical importance of gall bladder. [4+4+4][2005]

13. Describe the formation of rectus sheath. Name the contents of the sheath. What is the

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function of tendinous insertions and at which level they are present? [6+3+1+2][2016]

14. Describe the shutter mechanism of inguinal canal and anatomical difference b/w oblique

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and direct hernia.[6+6][[2015]

15. Describe the internal features of anal canal with epithelial lining of each division. Why

the pectinate line is called watershed line of anal canal? What is the importance of

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Hilton's line? Mention the development of anal canal. Define internal haemarrhoids and
mention their common sites.[4+2+2+2+2][2017]

GROUP-B (7 MARKS) SHORT NOTES

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1. Describe the common bile duct in short. What is the importance of Calot's

triangle?[5+2][2014][2016]

2. What are the anatomical factors that prevent the gastro-esophageal regurgitation. Give an

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account of histological structures of oesophagous.[4+3][2013]

3. Give an account of uterine cervix. Mention its lymphatic drainage.[4+3][2013]
4. Describe the histology of classical hepatic lobule. What is liver acinus?[5+2][2012]

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5. Why is ischio-rectal abscess very painful when abscess is superficial. Write boundaries

and contents of the fossa.[1+4+2][2012]

6. Name the false ligaments of the liver. State within which mesogastrium development of

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liver takes place and what are the remnants of it. Write from which part of gut, liver bud
develops? [4+1+1+1][2011]

7. Name the parts of the large intestine with their corresponding length in adults. Describe

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the structures of large gut with diagrams.[2.5+4.5][2011]

8. A teenaged girl suffering from acute appendicitis got an initial attack of pain around

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umbilicus, which was finally localized in right iliac fossa. State anatomical reasons of
pain in the both areas. Give an account of positions of vermiform appendix.[3+4][2010]

9.

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After spleenectomy operation following an intra-abdominal injury, a patient develops

diabetes mellitus. Explain the reason from your anatomical knowledge. Discuss briefly
the ligaments of spleen cut during operation.[2+5][2009]

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10. Bouts of hematemesis following cirrhosis of liver of a patient were diagnosed to be due

to obstruction of portal venous system. Explain it. Give a brief account of portal vein
with a note on porta-caval anastomosis.[2+5][2008]

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11. What is spermatic cord? Name its contents. Describe the duct which conveys male germ

cells for ejaculation.[1+2+4][2007]

12. In case of intestinal obstruction, caecum is found to be distended. In which part of the gut

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does the obstruction lie? Give an account of the caecal blood supply. Describe the illio-
ceacal valve.[1+3+3][2006]
13. A middle aged woman complains of frequent heart burn about an hour after meals.

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Provisional diagnosis was made to be as a case of reflux oesophagitis. What are the
factors that prevents gastro-esophageal regurgitation? Give relations and arterial supply
of abdominal part of esophagus.[3+2+2][2004]

14. A patient was diagnosed to have polycystic kidney. Give the embryological basis of this

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condition. Illustrate your answer with diagrams.[5+2][2004]

15. Describe the inferior of anal canal along with its histological structure. [4+3][2015]
16. Describe the cervix uteri. What is its clinical importance? [5+2][2016]

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17. Describe the lymphatic drainage of stomach. Why does Virchow's lymph nodes get

enlarged in carcinoma of stomach?[5+2][2017]

GROUP-C (3 MARKS) SHORT NOTES

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1. Ovarian fossa on lateral pelvic wall.[2013, `07]
2. Epiploic foramen.[2012, `11]
3. Umbilical cord.[2012]
4. Left renal vein.[2011]

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5. Inter-vertebral disc.[2010, `08]
6. Physiological umbilical hernia.[2010]
7. Porto caval anastomosis.[2009]
8. Placenta previa.[2008]
9. Relations of head of pancreas.[2008]

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10. Pelvic mesocolon.[2007]
11. Hasselbach's triangle.[2009]
12. The bare area of liver.[2007]
13. Mackenrodt's ligament.[2012]
14. The mesentery.[2006]

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15. Renal fascia.[2006]
16. Intervillous space of placenta.[2006]
17. Histology of adrenal cortex.[2006]
18. Neural crest.[2005]
19. Ischio-rectal space.[2005]

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20. Openings of diaphragm.[2005]
21. Hepato-renal pouch of Morission.[2004]
22. Coeliac trunk.[2004]
23. Lesser sac.
24. Broad ligament.

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25. Ligaments of uterus.
26. Interior of caecum.
27. Space of Retzius.
28. Interior of 2nd part of duodenum.
29. Supports of uterus.

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30. Ligaments of urinary bladder.
31. Meckel's diverticulum.
32. Perineal body.
33. Duodenal cap.
34. Ligaments of Treitz.

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35. Inguinal canal.
36. Internal trigone of urinary bladder.[2014]
37. Broad ligament of uterus.[2014]
38. Prostatic part of male urethra.[2015]

--- Content provided by FirstRanker.com ---

GROUP-D (3 MARKS) EXPLAIN ANATOMICALLY

1. Varicocele of testis is common.[2014]
2. Carcinoma of head of pancreas may produce jaundice.[2014]
3. A new born baby presenting with imperforate anus.[2013, `05]

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4. Pain of appendicitis is referred to umbilicus.[2013, `04]
5. Cholecystitis causes pain in right shoulder.[2011]
6. Urinary fistula at the level of umbilicus in a new born baby.[2011]
7. A patient is detected to have horse-shoe shaped kidney.[2010]
8. A patient of cirrhosis of liver presents with "Caput Medusa".[2010]

--- Content provided by FirstRanker.com ---

9. Pectinate line is an important landmark of anal canal.[2009]
10. Rupture of membranous part of urethra may cause extravasation of urine in anterior

abdominal wall.[2008, `05]

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11. Incidence of inguinal hernia in normally healthy individual is prevented by shutter

mechanism.[2008]

12. Peritoneal infection from exterior is common in females.[2007]

--- Content provided by FirstRanker.com ---

13. Varicosity of pampiniform plexus of vein is more common in left side.[2007]
14. Non-appearance of ureteric bud on one side leads to agenesis of kidney on the same

side.[2007]

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15. The vermiform appendix can be regarded as tonsil of abdomen.[2007]
16. During the resction of diseasd caecum, the ascending colon, the surgeon usually removes

the terminal 8-10 cm of ileum also.[2006]

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17. Pain of ureteric colic radiating in the medial side of the thigh.[2005]
18. An old man suffering from carcinoma of prostate develops vertebral metastasis.[2004]
19. Appendix of testes is embryologically different from appendix of epididymis.[2017]
20. Pleural sac may be accidentally opened during exposure of kidney from back.[2017]
21. New born baby passes urine through umbilicus.[2016]

--- Content provided by FirstRanker.com ---

22. Pubic tubercle is important landmark for femoral and inguinal hernia.[2016]
23. In prostatic carcinoma, X-ray of lumbosacral vertebrae to be advised.[2016]
24. Dropping of the kidney is not followed by suprarenal gland.[2016]
25. Caput medusa. [2015]
26. Inner layer of myometrium acts as a living ligature of uterus during menstruation &

--- Content provided by FirstRanker.com ---

parturition.[2015]
HEAD AND NECK

GROUP-A(12 MARKS)

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1. A man suffering from hypertension, bleed from Little's area of nose. Give an account on

the formation, arterial supply, nerve supply, and lining epithelium of the nasal septum
with a note on Little's area.[4+2+2+2+2][2012]

--- Content provided by FirstRanker.com ---

2. Following throidectomy, a patient may develop hoarsness of voice. Explain the statement.

Give a brief account of intrinsic muscles of larynx and their action on Rima
glottides.[2+10][2012]

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3. A child came to the OPD with a complaint of injury to the external ear. On examination,

a perforation was found in the tympanic membrane. Discuss the gross anatomy, arterial
supply, and nerve supply of tympanic membrane & external auditory

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canal.[3+1+2+3+1+2][2011]

4. A person with history of inability to close his mouth immediately after yawning. What is

the anatomical basis of it? Describe the muscles and ligaments related to the anatomical

--- Content provided by FirstRanker.com ---

site affected.[2+5+5][2011]

5. Following an operation of right parotid gland, a patient develops weakness of facial

muscles of that side. State the relations of the affected cranial nerve with respect to the

--- Content provided by FirstRanker.com ---

parotid gland. Give a brief account of the functional components, intra cranial course and
distributions of the nerve. [2+10][2010]

6. A patient is brought to the physician presenting right sided ocular signs of ptosis,

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strabismus, diplopia and a loss of accommodations as well as the light reflex with the
contralateral hemiplagia. From your anatomical knowledge, explain the lesion. Give a
brief account of the cranial nerve affected.[2+10][2010]

7. A new born baby was found to have cleft palate with nasal regurgitation of milk during

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breast feeding. Explain the congenital defect from your anatomical knowledge with a
brief note on development of soft palate. Give a brief account on muscles of soft palate
with its movements during deglutition. [4+8][2009]

--- Content provided by FirstRanker.com ---

8. Following stroke, a man suffers from Weber's Syndrome, with left sided hemiplagia and

ptosis along with lateral strabismus and dilation of pupil of right eye. Using your
anatomical knowledge explain Weber's Syndrome & involvement of ocular muscles.
Discuss briefly the extrinsic muscles of the eyeball.[4+8][2009]

--- Content provided by FirstRanker.com ---

9. Following operation of thyroid gland, a patient develops hoarseness of voice. Give a brief

note on muscles acting on vocal cord and state from your anatomical knowledge what
happened wrong with the patient. Discuss the important relations and arterial supply &

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venous drainage of thyroid gland. Mention what precautions are to be taken by surgeon
during operation of thyroid gland based on your anatomical knowledge. [4+6+2][2008,
`05]

10. A patient suffering from parotid tumor , with malignant change gets complications of

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Bell's paralysis.Mention the anatomical changes that occurred in Bell's paralysis in this
case. Discuss briefly the important relations, structures passing through the inferior part
and the nerve supply of the parotid gland. [4+8][2008]
11. Give a brief account of vertebral artery. What contributions it makes to complete the

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circle of Willis?[12][2007]

12. A child aged about 10 yrs suffers from mid-ear infection following recurrent attacks of

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cough & common cold. From your anatomical knowledge answer its reasons and the
route of its further infection. Mention the position of the nuclei with the functional
components of the cranial nerves related to the walls of middle ear. Discuss briefly the
intra petrous part of the nerve. [ 4+4+4][2004]

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13. Describe cavernous sinus under the following headings:

A)General informations; B) Structures passing through the sinus; C)

Tributaries; D) Communications.[2017][3+3+3+3]

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GROUP-B ( 7 MARKS)

1. Name the paranasal air sinuses. Mention the factors which help to drain out the content of

the maxillary air sinus. Why theses sinuses are developed around the nose.[2+3+2][2014]

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2. Mention the muscles of pharynx. Give their nerve supply. What is Killian's dehiscence?

[3+2+2][2014]

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3. Enumerate the paired venous sinuses in skull. Right brief note on cavernous sinus.

[3+4][2013]

4. Fish bone badly stuck in pyriform fossa of pharynx was removed with prolonged effort

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causing laceration of tissue. Give boundaries of pyriform fossa, its sensory nerve supply
and possible deleterious effects of tissue damage.[2+2+2][2013][2004]

5. Write a note on internal capsule of brain with its blood supply. What is hemiplagia?

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[5+2][2012]

6. Describe the development of tongue. Correlate the nerve supply of tongue with its

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development.[4+3] [2012]

7. An old man presents an ulcer along the margin of tongue which was diagnosed as

carcinoma of the tongue. Which groups of lymph nodes are likely to be enlarged?

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Discuss briefly the lymphatic drainage of tongue.[2+5][2011]

8. A patient with increased intracranial tension presents with medial squint/ strabismus.

Explain the reason for medial squint. Give a brief account of the anatomy of the

--- Content provided by FirstRanker.com ---

structures involved.[2+5][2011]

9. During surgical operation of thyroid gland, a surgeon must be careful to avoid injury to

some nerves. Mention the components, distribution and effect of lesions of these

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nerves.[2+3+2][2010]

10. A boy presents discharge of pus through ear following recurrent infection of throat.

Explain the clinical complications. Write a brief note on the structures connecting ear

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with throat.[2+5][2009]

11. Neglected infection in dangerous area of face of a patient led to cavernous sinus

thrombosis . State the reason. Mention the communications and anatomical basic of

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complications arising fro+m the structures related to the thrombosed sinus. [2+5][2008]

12. Mention the coats of eyeball . How the aquous humor is formed, circulated and drained?

Name the refractive meium in the eye.[3+2+2][2007]

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13. What is Rima Glottidis? Name the boundaries and muscles controlling the shape of Rima

Glottidis under different physiological & functional conditions.[2+3+3][2007]
14. Name the different layers of deep cervical fascia. Trace any two layers vertically upwards

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and downwards. Which layer encloses the thyroid gland and explain why thyroid moves
with deglutition?[2+3+3][2007]

15. Explain the presence of thyroid glandular follicles in tongue. Describe the dorsum of the

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tongue. Give its sensory nerve supply. [2+3+2][2006]

16. What are the manifestations of occulomotor nerve lesion. Describe the course of the

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nerve in the middle cranial fossa & orbit. Explain the cause of lateral squint and dilated
pupil in occulomotor nerve palsy. [2+3+2][2006]

17. Acute maxillary sinusitis can cause toothache . Enumerate the paranasal air sinuses with

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their respective sensory innervations. Explain the cause of toothache. [5+2][2006]

18. An one month old baby was brought to OPD for constant watering of one eye. Explain

the anatomical cause and enumerate the structures forming the lacrimal apperatus. Trace

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the secretomotor pathway to lacrimal gland.[1+3+3][2005]

19. Enumerate the extra-occular musces with their nerve supply and functions.[4+3][2017]

GROUP-C(3 MARKS) SHORT NOTES

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1. Branchial cyst. [2013]
2. Otic ganglion.[2013]
3. Temporo-mandibular joint.[2013]
4. Danger area of face.[2013][2015-Explain Why]

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5. Ciliary ganglion.[2012]
6. Lacrimal aperatus.[2012]
7. Tymanic membrane.[2012]
8. Ansa cervicalis.[2012]
9. Inlet of larynx.[2011,'06,'05]

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10. Development of soft palate[2011]
11. Spine of sphenoid.[2011]
12. Thyroglossal duct.[2010]
13. Middle meatus of nose.[2010,'08]
14. Circulation of aquous humor.[2010]

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15. Cricoid cartilage[2009]
16. Superior cervical ganglion.[2009]
17. Iris.[2008]
18. Inferior Constrictor muscle.[2008]
19. Histology of palatine tonsil.[2007]

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20. Temporalis muscle.[2007]
21. Movement of temporo-mandibular joint.[2004]
22. Sternocleidomastoid muscle.[2005]
23. Lacrimal gland[2005]
24. Ciliary body.[2004][2016]

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25. Pyriform fossa with clinical importance.[2014]
26. Muscles of the first branchial arch with their nerve supply.[2014][2017]
27. Dangerous area of scalp.[2014][2016]
28. Styloid aperatus. [2014]
29. Spinal accessory nerve.[2017]

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30. Blood supply of spinal cord.[2017]
31. Transposition of great vessels.[2015]
32. Speech area of brain.[2015]
33. Structure and nerve supply of tympanic membrane.[2015]
34. Rima Glottidis.[2016]

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35. Nasolacrimal duct.[2016]

GROUP-D(3 MARKS) EXPLAIN WHY

1. Pain is referred to the middle ear in ulcer of posterior part of the tongue.[2014]

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2. A patient having fracture of sphenoidal spine complains of loss of taste sensation

at a later date.[2014]

3. Inflammation of parotid gland is very painful.[2014]

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4. In tonsillitis, pain is referred to the middle ear.[2013][2007][2015]
5. Superior parathyroids are inferior in position[2013,'11]
6. Optic disc in eye-ball is known as blind spot.[2013, `06]
7. Postero-inferior part of tympanic membrane is chosen for myringotomy.[2013]
8. Macular vision is generally spared in lesion of posterior cerebral artery.[2012]

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9. Optic nerve can not regenerate after injury.[2012]
10. A patient of pituitary tumor suffers from bitemporal hemianopia.[2014,'10][2016]
11. Layer of loose connective tissue of skull is known area of scalp.[2010,'08]
12. Repeated throat infection , if neglected, may cause mastoitidis.[2010,'08]
13. Supranuclear type of facial nerve lesion leads to motor loss of lower part of

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face.[2009]

14. Vocal cord is considered as water shed line of larynx.[2009]
15. Right recurrent laryngeal nerve hooks around right subclavian artey while the left

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one rounds the ligamentum arteiosum.[2008][2016]

16. Thyroglossal duct when present, extends above upto foramen caecum of

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tongue.[2007]

17. Types of articulation found with occipital bone.[2007]
18. Horner's Syndrome.[2006]
19. Branchial Cyst.[2005]

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20. Corneal reflex.[2005]
21. Cavernous sinus thrombosis following infection of face.[2004]
22. Following operation of thyroid gland, patient develops hoarseness of voice.[2004]
23. Surgeon thoroughly clear the blood clots from the tonsillar fossa after

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tonsillectomy operation.[2004]

24. Parotiditis is very painful.[2017]
25. Syringing of external ear may sometime cause vaso-vagal attack of the

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patient.[2016]

26. Obliquity and length of the spinal nerve roots increase progressively from above

downwards.[2016]

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27. Increased intra-cranial pressure may cause medial squint.[2015]
28. In anterior spinal artery syndrome there is bilateral loss of pain and temperature

sensation but conscious propioceptive sensations are preserved.[2015]

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29. Posterior crico-arytenoid muscle acts as safety muscle of larynx.[2015]
10 YEAR'S QUESTION PAPER FOR 1ST PROF MBBS EXAMINATION-
BIOCHEMISTRY

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CARBOHYDRATE CHEMISTRY- DIGESTION & ABSORPTION

GROUP-B (7 MARKS)

1. Indicate in details the chemical composition of glycosaminoglycans and proteoglycans.

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Name the carbohydrates present in glycoproteins and glycolipids.[5+2][2013][2015]

2. Describe the bonds present in glycosaminoglycans. Indicate the chemical difference b/w

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the proteoglycans & glycoproteins. [3+4][2006]

3. Define stereoisomerism. Describe different types of stereoisomerism of

glucose.[1+6][2005]

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4. Describe the various forms of isomerism exhibited by carbohydrates. Name the

carbohydrates present in glycoproteins. [5+2][2017]

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GROUP-C (3 MARKS) SHORT NOTES

1. Blood group antigens. [2010][2016]
2. Proteoglycans. [2009]
3. Glycosaminoglycans. [2004]

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4. Glycemic index of carbohydrates.[2017]
5. Invert sugar.[2017]
6. Glucose transporters.[2017]

GROUP-D( 3 MARKS) EXPLAIN WHY

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1. Glucose and fructose form similar osazone crystals. [2011]
2. Sucrose has no anomers.[2006]
3. Sucrose is a non-reducing sugar.[2005]
4. Defective lactose digestion may lead to a clinical condition.[2015]

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CARBOHYDRATE METABOLISM

GROUP-A(12 MARKS)

1. Describe in a flow diagram the metabolic pathways of glycogen formation and

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degradation in the body. Describe in separate charts how cyclic AMP regulates this
process by enzyme modification.[4+8][2013]

2. In a flow diagram , describe the metabolic steps of glycogenesis and glycogenolysis in

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muscle and show how cAMP integrates their regulation.[6+6][2010]

3. Describe the metabolic steps of citric acid cycle in a flow diagram indicating the enzymes

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and co-enzymes involved and highlighting the steps where the energy is produced.
Mention the steps in the cycle which are irreversible in nature. Indicate how propionate is
converted to one of the intermediates of this cycle.[8+2+2][2013]

4. With a suitable flow chart , describe the TCA cycle. Justify TCA cycle as the final

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common metabolic pathway.[7+5][2005]

5. In a flow diagram , indicate the metabolic steps by which propionate can be converted to

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glucose and show how key enzymes of gluconeogenesis are controlled.[6+6][2010]

6. How fructose and galactose are metabolized in the body? Mention the inherited disorders

related with their metabolism.[8+4][2006]

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7. On complete oxidation, glucose leads to production of carbon dioxide and water. Mention

those metabolic steps where carbon dioxides are evolved. Give a detailed account of
enzymes, co-enzymes and control mechanisms involved in these steps. Mention three

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examples of metabolic reactions where carbon dioxide is utilized in this
process.[6+3+3][2016]

GROUP-B ( 7 MARKS)

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1. Give a brief account of glycogen storage disease.[7][2014]
2. Describe in details how pyruvate is converted to Acetyl-CoA in the body.[7][2013]
3. Describe multi-enzyme complex and various reactions involved in the oxidation of

pyruvic acid to acetyl-CoA. [7][2011]

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4. Describe the HMP shunt pathway in a flow diagram.[7][2007]
5. Explain with a flow diagram how glycolysis and gluconeogenesis in the liver are

controlled by fructose 2,6 bisphosphate & the bifunctional enzyme 6-phosphofructo-2-

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kinase.[7][2017]

GROUP-C (3 MARKS) SHORT NOTES

1. Rapoport Leubering cycle. [2011][2017]

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2. Essential pentosuria.[2010][2016]
3. Glycogen Storage disease. [2009]
4. Role of vitamins in TCA cycle[2009]
5. Metabolic role of Glucuronic acid.[2008]
6. Regulation of pyruvate dehydrogenase complex. [2007]

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7. Key glycolytic enzymes. [2006]
GROUP-D (3 MARKS) EXPLAIN WHY

1. Phosphofructokinase I is known as pacemaker of glycolysis.[2012]
2. Von-Gierke's disease is associated with hyperuricemia.[2012][2017]

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3. Impairment of pentose phosphate pathway (PPP) leads to erythrocytic hemolysis.[2011]
4. G6PD deficiency leads to hemolytic anemia.[2009,'07]
5. Sodium fluoride is added to blood samples drawn for blood sugar estimation.[2008]
6. Long chain fatty acids can not be converted to glucose in human body though the reverse

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is possible.[2010]

7. Fat can be synthesized from glucose but glucose can't be synthesized from

fat.[2005][2016]

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8. Fructose leads to formation of more VLDL.[2008]
9. Galactosemic patients are often associated with congenital cataract.[2016]

LIPID CHEMISTRY- DIGESTION & ABSORPTION

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GROUP ? A (12 MARKS)

1. Classify phospholipids with examples. Mention their specific role in maintaining the

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fluidity of plasma membrane.[10+2][2013]

2. Classify different phospholipids of physiological importance with their

functions.[8+4][2004]

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GROUP-B (7 MARKS)

1. Tabulate a detailed account of chemical composition of plasma lipoproteins. [7][2010]
2. Describe amphiphatic lipids with examples. Describe their behavior in aquous medium.

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State the importance of liposomes in clinical practice.[2+3+2][2009]

3. Classify phospholipids. Indicate their specific role in maintaining plasma membrane

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fluidity.[3+4][2007]

4. Classify the fatty acids in details & indicate their physical properties.[5+2][2017]

GROUP-C (3 MARKS) SHORT NOTES

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1. Separation and identification of lipids by thin layer chromatography. [2013]
2. Eicosanoids.[2008]
3. Sphingolipids.[2008]
4. Gangliosides.[2006]

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5. Omega-3 fatty acids.[2015]
6. Glycosphingolipids[2017]
GROUP- D ( 3 MARKS) EXPLAIN WHY

1. Lecithin is amphipathic as well as amphoteric in nature.[2014]

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2. Arachidonic acid may not be considered as an essential fatty acid.[2010]
3. Intake of fish oils are beneficial for cardiac patients in contrast to animal fat.[2009]
4. Acid number helps in the identification of rancidity in fats and oils.[2016]

LIPID METABOLISM

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GROUP-A (12 MARKS)

1. Give an account of fatty acid synthase complex. Describe the metabolic pathway

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for de-novo synthesis of palmitate in the body.[3+9][2014]

2. Describe the metabolic steps of biosynthesis of cholesterol. Discuss the control

metabolism associated with HMG CoA reductase. Explain reverse cholesterol

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transport.[8+2+2][2017]

GROUP-B(7 MARKS)

1. Give the exact chemical composition of very low density lipoprotein. Explain their

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formation and fate inside the body.[2+5][2013]

2. Describe how ketone bodies are formed & subsequently degraded in the

--- Content provided by FirstRanker.com ---

body.[3+4][2015]

GROUP-C ( 3 MARK) SHORT NOTES

1. Control of HMG-CoA reductase.[2013]

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2. Role of carnitine in fatty acid metabolism.[2015]
3. Fatty acid synthase complex. [2017]

GROUP-D (3 MARKS) EXPLAIN WHY

--- Content provided by FirstRanker.com ---

1. Both uncontrolled diabetes mellitus and prolonged fasting produce ketosis but its

magnitude is less in the case of prolonged fasting.[2014]

2. Citric acid cycle operating in the mitochondria can take part in the extra mitochondrial

--- Content provided by FirstRanker.com ---

fatty acid synthesis.[2004]

3. Ketone bodies are degraded in the extrahepatic tissues only.[2013]
4. HDL is involved in reverse cholesterol transport.[2015]

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5. Lipoprotein lipase deficiency may lead to hyperglyceridemia.[2015]
6. Citrate plays an important role in fatty acid synthesis.[2017]
AMINO ACID , PROTIEN CHEMISTRY, DIGESTION AND
ABSORPTION & TISSUE

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PROTEINS AND PROTEIN

PURIFICATION

GROUP-A (12 MARKS)

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1. Describe the salient features of alpha helix and beta pleated sheet structure of proteins.

Mention the non-covalent interactions which stabilize protein confirmation. Briefly
discuss the role of peripheral & integral proteins in the network of plasma

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proteins.[4+3+5][2014]

2. Compare and explain the oxygen binding curves of hemoglobin and myoglobin. Indicate

the conformational changes that occur in hemoglobin on oxygenation. Mention the basic

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variations in the chemical structures of HbS and HbM as compared to the adult
hemoglobin.[6+3+3][2014][2016]

3. Describe how the amino acid composition, N-terminal & C-terminal residues of a protein

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are determined & identified. Describe the bonds responsible for the four structures of
proteins . Briefly indicate how a molecular weight of a protein is
determined.[7+3+2][2013]

4. Describe the peptide bond. What are the different forces that stabilize the protein

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structure at the different levels of organization ? Give an example to explain the primary
structure that determines the functional state of proteins.[4+5+3][2011]

5. Discuss the four orders of protein structures. Describe the alpha helical form of a globular

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protein. State briefly how the amino acid sequence in a polypeptide chain can be
determined.[6+2+4][2010]

6. Discuss briefly how the chemical structures of myoglobin and hemoglobin influence their

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biological activities. Describe the changes that take place in hemoglobin on oxygenation.
[6+6][2010]

7. Describe in detail how the number, kind and sequence of amino acids in a polypeptide

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chain are determined. [4+4+4]

8. Using hemoglobin and myoglobin as models , justify the statement, "Chemical structure

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of a protein decides its biochemical functions". [12][2007]

GROUP-B( 7 MARKS)

1. Describe the principles of electrophoresis. Illustrate with diagram the electrophoretic

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separation of the serum proteins indicating the significance of each separated band.
Explain the importance of acute phase reactants. [3+2+2][2014]

2. Describe the mechanism of absorption of amino acids from the gut. What is Hartnup's

--- Content provided by FirstRanker.com ---

disease?[5+2][2009]

3. Describe the primary, secondary and tertiary structures of the proteins mentioning the

--- Content provided by FirstRanker.com ---

forces that stabilize them.[7][2008]

4. Describe the chemical structure of collagen and the chemical reason for its toughness.

[5+2][2007]

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5. Describe briefly the chemical structures of hemoglobin. Compare the chemical structures

of hemoglobin and myoglobin. Explain how oxyhemoglobin and deoxyhemoglobin act as
buffers in the maintenance of acid base balance in our body.[2+1+4][2006]

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6. Give an outline of procedure for determination of primary structure of a protein having

single polypeptide chain. [7] [2005]

7. Name the different immunoglobulins. Give the structure and functions of IgG.

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[2+5][2004]

8. Classify L-amino acids present in the proteins. Explain how amino acids are separated

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and identified from a mixture of amino acids . [2+5][2015]

GROUP-C (3 MARKS) SHORT NOTES

1. Glycosylated Hemoglobin.[2011]

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2. Prions.[2011]
3. Protein folding.[2007][2015]
4. Bonds maintaining the tertiary structure of protein. [2006]
5. 2,3 BPG on Hb-Oxygen interaction.[2004]
6. Selenocystine. [2015]

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7. Electrophoresis. [2016]
8. Beta pleated sheet. [2017]

GROUP ?D ( 3 MARKS) EXPLAIN WHY

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1. Patient with Hb-S often suffers from anemia.[2013][2017]
2. Collagen has quarter staggered triple helical structure.[2012]
3. Glycine solution can not rotate the plane of plain polarized light.[2012]
4. 2,3 BPG helps in delivery of Oxygen to the tissues.[2011]
5. 2,3 BPG helps in decreasing the affinity of hemoglobin towards oxygen. [2007]

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6. Both protein and urea give positive biuret test. [2005]
7. Chaperons play a very significant role in protein folding.[2016]
8. Hb-A1c provides valuable information for management of diabetes mellitus.[2016]
9. Myoglobin does not exhibit Bohr effect.[2015]
AMINO ACID AND PROTEIN METABOLISM

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GROUP-A (12 MARKS)

1.

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Describe how catabolism of haem produces bilirubin. Indicate in details the process of
uptake, conjugation and secretion involved in transfer of bilirubin from blood to
bile.[6+6][2014]

2.

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Describe the formation and degradation of epinephrine in the body. [7+5][2007]

GROUP-B (7 MARKS)

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1. Describe the process of transamination and oxidative deamination in the

body.[4+3][2014]

2. Write the synthesis, transport and degradation of catecholamines.[7][2011]

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3. Describe how catecholamines are synthesized and degraded inside the human

body.[3+4][2010]

4. What are the metabolic products of tyrosine? Describe with suitable flow chart the

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biosynthesis of catecholamines.[2+5][2008]

5. Describe the formation and fate of ammonia inside the body.[2+5][2009]/[3+4][2006]
6. Give the reaction intermediates and bioenergetics of urea cycle .[3+3+1][2004]

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7. Write down with flow chart the steps of catabolism of carbon skeleton phenylalanine &

mention the steps which are blocked in phenylketonuria and alkaptonuria.[5+2][2005]

GROUP- C ( 3 MARKS ) SHORT NOTES

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1. Acute intermittent porphyria.[2014]
2. S-Adenosyl Methionine.[2013]
3. Maple Syrup Urine Disease. [2010]
4. Polyamines. [2010]

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5. Phenylketonuria.[2004]

GROUP- D( 3MARKS) EXPLAIN WHY

1. Patient with carcinoid syndrome may exhibit pellagra.[2013]

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2. Alkaptonuria is often associated with generalized pigmentation of connective tissue

(Ochronosis). [2013]

3. Ammonia is toxic to Central Nervous System. [2012]

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4. Phototherapy ( exposure to blue light) helps in treatment of neonatal physiological

jaundice.[2011]

5. Urine turns black on standing in Alkaptonuria.[2010]

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6. Urinary urobilinogen is increased in hemolytic jaundice . [2009]
7. Proteinuria. [2004]
CHEMISTRY OF NUCLEOTIDES AND NUCLEIC ACIDS

GROUP- B ( 7 MARKS)

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1. With the help of a diagram describe the chemical structure of a tRNA and mention the

function of its different arms.[3+4][2007]

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2. Give the structure of a deoxyribonucleotide. Write down with the help of a diagram and

mention its different functions. [2+5][2005]

GROUP- C (3 MARKS)

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1. t-RNA.[2011]
2. Synthetic nucleotide analogues. [2009]
3. Pseudo nucleotides. [2007]
4. Structural features of A, B and Z-DNA.[2007]

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5. Bonds in polynucleotides.[2017]

GROUP-D (3 MARKS) EXPLAIN WHY

1. DNA with higher GC content have relatively higher Tm.[2014]

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2. RNA is alkali labile while DNA is alkali resistant.[2012]
3. DNA can occur in different 3D models.[2004]
4. Synthetic nucleotides are used as drugs.[2015]
5. DNA is more stable than RNA.[2016]
6. Adenine nucleotides have various functions beside making nucleic acids. [2017]

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NUCLEOTIDE METABOLISM

GROUP-B (7 MARKS)

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1. Name the endpoint of purine catabolism and process of breakdown of purine. [2+5][2008]
2. Indicate the source of nitrogen and carbon atoms of the purine ring in a diagram.

Describe how purines are catabolised.[7][2006]

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GROUP-C ( 3 MARKS) SHORT NOTES

1. Gout.[2013]
2. Source of nitrogen and carbon atoms of the purine ring.[2013]
3. Purine salvage pathway. [2005]

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GROUP-D ( 3 MARKS) EXPLAIN WHY

1. Dietary purines are not essential.[2008]
2. Intake of alcohol may aggravate the symptoms of gout.[2016]

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3. Synthetic nucleotides are used as drugs.[2015]
BIOLOGICAL OXIDATION

GROUP ? A (12 MARKS)

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1. Explain oxidative level & substrate level phosphorylation. Give two examples of

substrate level phosphorylation. Explain the mitochondrial electron transport
chain.[2+2+8][2008]

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2. Describe with diagram the respiratory chain complexes that span the inner mitochondrial

membrane indicating the specific sites of energy production. What are its mobile
components? Mention the role of inhibitors of respiratory chain. What purpose is served
by their use in vitro. What happens when complex I is deficient? [5+2+5+1][2006]

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GROUP-B (7 MARKS)

1. Describe the operation and significance of glycerophosphate shuttle and malate

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shuttle.[3+4][2014]

2. What is oxidative phosphorylation? Differentiate it from substrate level phosphorylation.

Illustrate with a diagram how ATP is synthesized in mitochondria?[2+2+3][2014]

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3. Describe the mitochondrial electron transport chain. How the inhibitors of ETC differ

from uncouplers of oxidative phosphrylation?[5+2][2011]

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4. Describe the chemiosmotic coupling hypothesis of oxidative phosphorylation. [7][2010]

GROUP-C (3 MARKS) SHORT NOTES

1. Uncouplers.[2004]

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2. Malate shuttle.[2005]

GROUP-D(3 MARKS) EXPLAIN WHY

1. G6PD is responsible for erythrocyte membrane rigidity. [2014]

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2. Brown adipose tissue promotes thermogenesis. [2011, `10]

CLINICAL FUNCTION TEST, MEMBRANE TRANSPORT

AND ENZYMES

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GROUP-A (12 MARKS)

1. Explain the Michaelis Menten equation and explain the role of substrate concentration on the rate

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of enzyme catalyzed reaction with the help of graphs. Illustrate how Vmax and Km are affected
by competitive and non competitive inhibition of enzymes. " The Km value for glucokinase is
much higher than that for hexokinase though both act on glucose"- explain the
statement.[6+4+2][2017][2013]

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2. Name 5 enzymes whose catalytic activities are altered by covalent phosphorylation-

dephosphorylation and indicate their functions. According to International Union of
Biochemists, enzymes are classified into six major groups. Indicate in which groups the
following enzymes belong:

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A) Adenylate cyclase,
B) DNA dependant RNA polymerase.
C) Aldolase,
D) Chymotrypsin,
E) Reverse Transcriptase,

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F) Enolase
G) Acetyl CoA carboxylase. [5+7][2017][2015]

GROUP-B(7 MARKS)

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1. Describe the renal mechanism for regulation of acid base balance. What is the

biomedical importance of anion gap?[4+3][2014]

2. Define jaundice. With the help of liver function test and urine test, show it can be

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differentiated b/w hepatocellular and obstructive jaundice. [2+5][2008]

3. Explain the mechanism of allosteric regulation of enzyme activity using PFK as an

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example. Mention the other mechanisms by which the enzyme action is
regulated.[4+3][2016]

4. Describe the methods of determining the chemical structure of any unknown

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biomolecule.[7][2017]

GROUP- C ( 3 MARKS) SHORT NOTES

1. Receptor mediated endocytosis.[2014]

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2. Ionophores.[2014]
3. Respiratory acidosis. [2013]
4. Non functional plasma enzymes.[2016]

GROUP-D( 3 MARKS) EXPLAIN WHY

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1. Renal clearance study is an early predictor of impending renal failure.[2014]
2. Isoenzymes of Alkaline Phosphatase are of diagnostic significance.[2014]
3. Non function plasma enzymes are important only for clinical purposes.[2014]
4. Levels of hepatic enzymes can differentiate b/w hemolytic, hepatocellular and

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obstructive jaundice.[2013]

5. Colloids are biologically important having clinical significance.[2013]
6. The mode of action of metallo-enzymes and metal activated enzymes are different.[2013]

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7. The concentration of creatinine in blood predicts renal function of an individual.[2008]
8. Isoenzyme assay is helpful in the diagnosis of MI.[2015]
FREE RADICALS AND ANTIOXIDANTS

GROUP-B(7 MARKS)

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1. What are free radicals? How do they damage the biological systems? Name the various

antioxidants protecting the organisms. [1+3+3][2009]

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2. Describe the reactions catalyzed by the enzyme superoxide-dismutase. Describe the Cyt-

P450 dependant microsomal hydroxylation reaction. Mention two examples of
hydroxylation reactions where ascorbic acid is involved.[1+5+1][2006]

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GROUP- C ( 3 MARKS) SHORT NOTES

1. Biochemical functions of peroxisomes.[2014]
2. Antioxidant enzymes. [2014]
3. Role of Cyt-P450 in hydroxylation reaction.[2013]

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4. Super-oxide dismutase.[2013]
5. Glutathion.[2008]

GROUP-D( 3 MARKS) EXPLAIN WHY

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1. Superoxide dismutase protects aerobic organisms against oxygen toxicity.[2008]
2. Lipid peroxidation is a source of free radicals.[2007]
3. Defence mechanisms of the body to fight the toxicity of free oxygen species.[2004]
4. ROS damages cellular architecture.[2006]

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CELL CYCLE AND CANCER, VITAMINS AND MINERALS

GROUP-C (3 MARKS) SHORT NOTES

1. Tumor markers.[2014]

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2. Ceruloplasmin. [2014]
3. Cell cycle regulators.[2010]
4. Proto-oncogenes. [2009]
5. Activation of Proto-oncogenes.[2006]
6. Marker Enzymes.[2006]

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GROUP ? D ( 3 MARKS) EXPLAIN WHY

1. Radio Immuno Assay techniques has got demerits also.[2013]
2. Methotrexate is used for anti-cancer therapy.[2012, `11]

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MOLECULAR ENDROCRINOLOGY AND

SIGNALTRANSDUCTION

GROUP-A( 12 MARKS)

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1. Explain how normal blood sugar is maintained by various mechanisms.[12][2008, `04]

GROUP-B (7 MARKS)

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1. Explain the mechanisms of signal transductions by cAMP, calcium and phosphatidyl

inositol system with the help of diagrams.[7][2013]

2. In a flow diagram describe how insulin and glucagon regulate the process of

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lipogenesis and lipolysis in adipose tissue. [7][2010]

3. Discuss the different types of G-protein coupled signal transduction

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processes.[7][2010]

GROUP-C (3 MARKS) SHORT NOTES

1. G-protein[2011]

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2. 3`-5` cAMP. [2004]
3. Receptors in signal transductions.[ 2007]
4. Insulin receptors. [2006]
5. Receptor enzymes. [2005]
6. Calcium as 2nd messenger. [2005]

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GROUP-D (3 MARKS) EXPLAIN WHY

1. Calcium as 2nd messenger.[2004]
2. Lipids can act as intracellular signals.[2012]

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3. Receptor enzymes show intrinsic catalytic activity.[2009]

MOLECULAR BIOLOGY & GENETICS

GROUP-A ( 12 MARKS)

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1. Describe the stage of initiation of translation process with the help of a diagram. State

the mechanism of action of the following antibiotics in the inhibition of translation:

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A) Streptomycin,
B) Erythromycin,
C) Chloramphenicol. [6+6][2011]

2. Write down the different types of DNA damage. Explain the mechanisms of : Mismatch

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DNA repair, Base excision repair, Nucleotide excision repair. [6+6][2011]

3. Describe the process of synthesis of proteins in prokaryotes. What are the roles of

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different antibiotics to inhibit the process of translation in prokaryotes. [8+4][2009]

4. Describe the process of replication in E.Coli with suitable diagram. Mention the

differences among different E.Coli polymerases.[8+4][2008,'05]

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GROUP-B(7 MARKS)

1. Describe the initiation, elongation and termination phase of transcription in

eukaryotes. Name the antibiotics which specifically inhibit the microbial protein

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synthesis.[5+2][2015-12 marks] [2013]

2. Describe how ribonucleic acid is synthesized . Indicate the difference b/w DNA

Polymerase III and RNA polymerase.[5+2][2010]

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3. Indicate the different mechanisms of DNA repair.[7][2007]
4. Define mutation. Describe different types of mutations with examples.[1+6][2005]
5. Describe the operon model. Explain how it functions.[4+3][2004]
6. Give an account of negative and positive regulation of lac operon in E.Coli. [2015][7]

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7. Enumerate the DNA damaging agents and indicate the types of damages made by

them.[7][2017]

GROUP-C ( 3 MARKS) SHORT NOTES

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1. Eukaryotic topoisomerase. [2014]
2. Polyclonal antibodies. [2014]
3. Radioisotopes. [2014]
4. Base excision repair of DNA.[2013]

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5. Frame shift mutation. [2013]
6. Restriction Fragment Length Polymorphism (RFLP). [2011]
7. Monoclonal antibodies. [2011]
8. Gene therapy. [2009]
9. RNA processing. [2009]

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10. Ribozyme.[2008, `07]
11. Restriction Endonuclease enzyme.[2008, `06]
12. Genome of Retrovirus. [2007]
13. PCR( Polymerase Chain Reaction). [2005]
14. Mismatch DNA repair. [2005]

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15. Point mutation. [2016]
16. DNA replication in eukaryotes and prokaryotes.[2015]
17. RNA editing.[2015]

GROUP-D ( 3 MARKS) EXPLAIN WHY

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1. RNA can act as enzyme.[2011]
2. DNA denaturation is essential for hybridization. [2007]
3. Genetic code is degenerative and unambiguous. [2005]
4. DNA is much more stable than RNA. [2016]

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5. Ribosome is the ultimate ribozyme.[2017]