GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER- V (New) EXAMINATION - WINTER 2019
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Subject Code: 2153601 Date: 21/11/2019
Subject Name: Pharmaceutical Chemistry
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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MARKS
Q.1 (a) What are Antithyroid drugs? Give two examples with structure 03
(b) Suggest a commercial root for the synthesis of anticonvulsant drug 04 Phensuximide which is having a 5 membered Pyrrolidine dione ring.
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(¢) Write the MOA & Synthesis of Oral anti-diabetic drug- Pioglitazone. 07
Q.2 (a) Write any four guidelines for choosing a disconnection in organic synthesis 03 by synthon approach. Give suitable examples.
(b) What are the classifications of Androgens? What are the therapeutic uses of 04 Androgens? Give two examples of Androgens with structure.
(¢) Name the Thyroid hormones and write their functions. Write the synthesis 07 of Thyroid drug-Levothyroxine.
OR
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(¢) By disconnection approach, suggest a scheme for the synthesis of anti- 07 malarial drug Chloroquine having a quinoline structure.
Q.3 (a) By disconnection approach, suggest a scheme for the synthesis of 03 Isoproterenol
(b) Write the metabolism of Testosterone. 04
(¢) By disconnection approach suggest a scheme for the synthesis of 07 Antifungal Econazole
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(a) Write any four guidelines for choosing a disconnection in organic synthesis 3 by synthon approach. Give suitable examples.
(b) By disconnection approach arrive at the starting material for the organic 04 synthesis of the Cis isomer of anti-cancer drug Combretastatin A-4. Discuss the strategies employed to get the Cis isomer
(¢) What are Hormonal Contraceptives? Describe the classifications of Oral 07 contraceptive with suitable examples.
Q4 (a) Write down the general names and structures of steroids having 18, 19, 21 03 and 27 carbons.
(b) By disconnection approach arrive at a suitable scheme for the synthesis of 04 Propranolol
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(c) Write the SAR of Progesterones 07
OR
Q4 (a) Write the structures of following: (1). 5B, 19-nor-androst-3-one, (2). 03 11B,17a,21-trihydroxypregn-4-ene-3,20-dione.
(b) Briefly describe Calcium Homeostasis 04
(¢) Write the synthesis of (1R,2S)(-)Ephedrine by disconnection approach. 07 Describe the separation of (1R,2S)(-) Ephedrine from the 4 isomeric mixtures obtained from the chemical synthesis.
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Q5 (a) Write the Mode of Action (MOA) & Structural Activity Relationship (SAR) 03 of Sulphonyl Urea class of oral hypoglycaemic drugs.
(b) Write the metabolism of Oestrogens 04
(c) Write the synthesis of third generation Cephalosporin drug-Cefotaxime 07 using 7-ACA
OR
Q.5 (a) Write the classifications of hormones. 03
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(b) By synthon approach, suggest a scheme for the synthesis of HI- 04 Antihistamine-Meclizine
(¢) Describe the chemical degradation of Penicillin 07
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